Ivermectin-Loaded Polymeric Nanoparticles: Screening the Effects of Polymers, Methods, and the Usefulness of Mathematical Models

Tavares, Eraldo José Madureira; Araújo, Daniele Ribeiro de; Fraceto, Leonardo Fernandes

doi:10.1166/jnn.2017.13111

Cited by 4 publications

(2 citation statements)

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“…As summarized in Table 4 and Figure S1 , the zeta potentials of all LPNC formulations were in the negative range, fluctuating from −7.55 ± 1.7 (S2-LPNCs) to −13.4 ± 2.1 mV (S4-LPNCs). The negative zeta potential of all formulations might be ascribed to the presence of the terminal carboxylic acid group in PLGA used as a shell-forming polymer [ 42 ]. This negative zeta potential might contribute to the colloidal stability of formulated LPNCs via hindering particle aggregation and/or precipitation by virtue of electrostatic repulsion between negatively charged surfaces.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives

et al. 2023

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This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid- and polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The nanocapsules were fabricated using a nanoprecipitation technique and characterized for particle size, surface morphology, and entrapment efficiency. The prepared nanocapsules exhibited a particle size ranging from 185.0 ± 17.4 to 223.0 ± 15.3 nm and a drug entrapment of >90%. The microscopic evaluation demonstrated spherical-shaped nanocapsules with distinct core–shell structures. The in vitro release study depicted a biphasic and sustained release pattern of test compounds from the nanocapsules. In addition, it was obvious from the cytotoxicity studies that the nanocapsules showed superior cytotoxicity against both MCF-7 and A549 cancer cell lines, as manifested by a significant decrease in the IC50 value compared to free test compounds. The in vivo antitumor efficacy of the optimized nanocapsule formulation (S4-loaded LPNCs) was investigated in an Ehrlich ascites carcinoma (EAC) solid tumor-bearing mice model. Interestingly, the entrapment of the test compound (S4) within LPNCs remarkably triggered superior tumor growth inhibition when compared with either free S4 or the standard anticancer drug 5-fluorouracil. Such enhanced in vivo antitumor activity was accompanied by a remarkable increase in animal life span. Furthermore, the S4-loaded LPNC formulation was tolerated well by treated animals, as evidenced by the absence of any signs of acute toxicity or alterations in biochemical markers of liver and kidney functions. Collectively, our findings clearly underscore the therapeutic potential of S4-loaded LPNCs over free S4 in conquering EAC solid tumors, presumably via granting efficient delivery of adequate concentrations of the entrapped drug to the target site.

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Section: Resultsmentioning

confidence: 99%

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives

et al. 2023

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“…Most of these technologies make use of hybrid lipid and polyanhydride-based materials. These nanodevices were employed to study the effect of ivermectin as an antiparasitic agent or against microfilaria and scabies. − However, most of these nanomaterials lack detailed characterization, targeted delivery to a specific site, or antiviral activity (Table S1). Additionally, there is low IVM loading in these NPs which typically are large in size, limiting their translation to therapeutic use.…”

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confidence: 99%

Orally Administrable Therapeutic Synthetic Nanoparticle for Zika Virus

et al. 2019

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The spread of Zika virus (ZIKV) infection across the USA and various countries in the last three years will not only have a direct impact on the U.S. health care system but has caused international concerns as well. The ultimate impact of ZIKV infection remains to be understood. Currently, there are no therapeutic or vaccine options available to protect those infected by ZIKV. The drug ivermectin (IVM) was found to be a viable agent for the prevention of transmission of ZIKV.

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A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases

Mohammed,

El-Megrab,

Hasan

et al. 2024

European Journal of Pharmaceutical Sciences

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Ivermectin-Loaded Polymeric Nanoparticles: Screening the Effects of Polymers, Methods, and the Usefulness of Mathematical Models

Abstract: Fonte referencial de informaÃ §Ã£o para a Pesquisa Apoiada pela FAPESP (ReferÃªncia obtida automaticamente do Web of Science, por meio da informaÃ §Ã£o sobre o financiamento pela FAPESP e o nÃºmero do processo correspondente, incluÃda na publicaÃ §Ã£o pelos autores.

Cited by 4 publications

References 0 publications

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives

Orally Administrable Therapeutic Synthetic Nanoparticle for Zika Virus

A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases

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