Kameraszintigraphie und Isotopennephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie<sup>*</sup>

zum, Winkel K; Hallwachs, O.; Steinhausen, M.

doi:10.1055/s-0029-1228345

Cited by 14 publications

(2 citation statements)

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“…Evaluation of renal function can be further enhanced by measurements of tubular dynamics, reflecting in vivo the degree of fluid reabsorption along the nephron (18). EBCT-measured loop of Henle and distal tubular transit times (Table 1) agreed closely with those previously measured in dogs using micropuncture and intra-arterial injections of lisamine green (36,41). Our proximal tubular transit time was longer than previously reported (16-22 s), probably due to different administration routes of indicator (intravenous vs. intra-arterial injections) as well as species differences (22).…”

Section: Discussionsupporting

confidence: 72%

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Krier

Ritman

Bajzer

et al. 2001

American Journal of Physiology-Renal Physiology

144

204

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To assess the reliability of electron beam computed tomography (EBCT), measurements of single-kidney renal blood flow (RBF), glomerular filtration rate (GFR), and intratubular contrast medium concentration (ITC) of radiographic contrast media were quantified in anesthetized pigs before and after acetylcholine-induced vasodilation and diuresis. EBCT measurements were compared with those obtained with intravascular Doppler and inulin clearance. The capability of EBCT to detect chronic changes in single-kidney function was evaluated in pigs with unilateral renal artery stenosis, and their long-term reproducibility in normal pigs was studied repeatedly at 1-mo intervals. EBCT-RBF (ml/min) correlated with Doppler-RBF as RBF(EBCT) = 45 + 1.07 * RBF(Doppler), r = 0.81. EBCT-GFR (ml/min) correlated with inulin clearance as GFR(EBCT) = 11.7 + 1.02 * GFR(inulin), r = 0.80. During vasodilation, RBF and GFR increased, whereas ITC decreased along the nephron. In renal artery stenosis, single-kidney GFR decreased linearly with the degree of stenosis, and ITC increased along the nephron, indicating increased fluid reabsorption. EBCT-RBF, GFR, and ITC were similar among repeated measurements. This approach might be invaluable for simultaneous quantification of regional hemodynamics and function in the intact kidneys, in a manner potentially applicable to humans.

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Section: Discussionsupporting

confidence: 72%

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Krier

Ritman

Bajzer

et al. 2001

American Journal of Physiology-Renal Physiology

144

204

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“…It has been shown by others that the contrast material that was used in this study is primarily cleared by filtration at a rate comparable to that of inulin (Zurth, 1984). We did not attempt to observe tubular transit of the filtered contrast medium in this experiment; however, others (Zum Winkel et al, 1968, 1971 have shown that the tubular transit times are much slower than the vascular transit times, lasting several minutes. Hence, with longer scans, it may be possible to assess tubular transit of contrast material as well as vascular transit.…”

Section: Distance From Outer Surface (Mm)mentioning

confidence: 87%

Three‐dimensional canine renovascular structure and circulation visualized in situ with the dynamic spatial reconstructor

Bentley¹,

Hoffman²,

Fiksen-Olsen³

et al. 1988

Am. J. Anat.

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The dynamic spatial reconstructor--a unique, high speed, volume-scanning, X-ray computed tomographic imaging system--was utilized to examine canine renovascular anatomy and renal circulation in situ. In each of the four kidneys examined in this study initial scans were done during bolus injections of angiographic contrast material into the renal artery. A subsequent scan was then performed following an injection of methyl-methacrylate-based casting compound that had been contrast enhanced with ethiodol. After the scans, each kidney was removed, and its parenchyma was digested in potassium hydroxide to expose the vascular cast. Comparison of casts with their reconstructed images and with images obtained during injection of contrast material showed that interlobar arteries and occasionally arcuate arteries could be clearly detected. Although discrete vessels less than 1 mm in diameter could not be resolved, dynamic changes in parenchymal distribution of density during passage of contrast material allowed interpretation of flow through the multiple capillary beds of the kidney. Such analysis indicated that maximal density was in the outer-middle zone of the cortex throughout the duration of the scan. Analysis of artery-to-vein transit time showed arrival of contrast material in the renal vein as soon as 3 sec, and continuation for longer than 8 sec, after the renal artery bolus. In conclusion, renal circulation in the dog can be discretely visualized with the dynamic spatial reconstructor up to the level of the arcuate arteries; however, capillary flow as a whole can be followed through the cortex, and the results suggest the presence of both rapid and slow components of peritubular circulation.

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Interpretation of Radioisotope Renogram Changes During Acute Toxic Renal Insufficiency Due to Oxalic Acid

Pavel¹

1971

Frontiers of Nuclear Medicine/Aktuelle Nuklearmedizin

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Kameraszintigraphie und Isotopennephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie^*

Cited by 14 publications

References 0 publications

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Three‐dimensional canine renovascular structure and circulation visualized in situ with the dynamic spatial reconstructor

Interpretation of Radioisotope Renogram Changes During Acute Toxic Renal Insufficiency Due to Oxalic Acid

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Kameraszintigraphie und Isotopennephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie*

Cited by 14 publications

References 0 publications

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

Three‐dimensional canine renovascular structure and circulation visualized in situ with the dynamic spatial reconstructor

Interpretation of Radioisotope Renogram Changes During Acute Toxic Renal Insufficiency Due to Oxalic Acid

Contact Info

Product

Resources

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Kameraszintigraphie und Isotopennephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie^*