Kidney injury molecule‐1 and <i>N</i>‐acetyl‐ß‐<scp>d</scp>‐glucosaminidase in chronic heart failure: possible biomarkers of cardiorenal syndrome

Jungbauer, Carsten; Birner, Christoph; Jung, Bettina; Büchner, Stefan; Lubnow, Matthias; Bary, Christian von; Endemann, Dierk; Banas, Bernhard; Mack, Matthias; Böger, Carsten A.; Riegger, Günter A.J.; Luchner, Andreas

doi:10.1093/eurjhf/hfr102

Cited by 122 publications

(108 citation statements)

References 26 publications

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“…Systemic upregulation of L-FABP in transgenic mouse models protects against AKI, suggesting a protective effect of L-FABP (13,25). KIM-1 and L-FABP are elevated in various settings of kidney injury and CKD, reflecting tubular injury (12,(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery

Parikh¹,

Thiessen-Philbrook²,

Garg³

et al. 2013

Clinical Journal of the American Society of Nephrology

205

179

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SummaryBackground and objectives AKI is common and novel biomarkers may help provide earlier diagnosis and prognosis of AKI in the postoperative period.Design, setting, participants, & measurements This was a prospective, multicenter cohort study involving 1219 adults and 311 children consecutively enrolled at eight academic medical centers. Performance of two urine biomarkers, kidney injury molecule-1 (KIM-1) and liver fatty acid-binding protein (L-FABP), alone or in combination with other injury biomarkers during the perioperative period was evaluated. AKI was defined as doubling of serum creatinine or need for acute dialysis.Results KIM-1 peaked 2 days after surgery in adults and 1 day after surgery in children, whereas L-FABP peaked within 6 hours after surgery in both age groups. In multivariable analyses, the highest quintile of the first postoperative KIM-1 level was associated with AKI compared with the lowest quintile in adults, whereas the first postoperative L-FABP was not associated with AKI. Both KIM-1 and L-FABP were not significantly associated with AKI in adults or children after adjusting for other kidney injury biomarkers (neutrophil gelatinaseassociated lipocalin and IL-18). The highest area under the curves achievable for discrimination for AKI were 0.78 in adults using urine KIM-1 from 6 to 12 hours, urine IL-18 from day 2, and plasma neutrophil gelatinaseassociated lipocalin from day 2 and 0.78 in children using urine IL-18 from 0 to 6 hours and urine L-FABP from day 2.Conclusions Postoperative elevations of KIM-1 associate with AKI and adverse outcmes in adults but were not independent of other AKI biomarkers. A panel of multiple biomarkers provided moderate discrimination for AKI.

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Section: Discussionmentioning

confidence: 99%

Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery

Parikh¹,

Thiessen-Philbrook²,

Garg³

et al. 2013

Clinical Journal of the American Society of Nephrology

205

179

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“…Previous studies on urinary NAG have mainly focused on NAG as a diagnostic and prognostic marker in patients with AKI. 5,24,25 Urinary NAG as a prognostic marker in persons with chronic disease has been studied in patients with heart failure 23,26,27 and diabetes. 21 In two clinical studies of patients with chronic heart failure and apparently normal kidney function, urinary NAG was associated with left ventricular dysfunction, and predicted all-cause mortality and rehospitalization for congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…21 In two clinical studies of patients with chronic heart failure and apparently normal kidney function, urinary NAG was associated with left ventricular dysfunction, and predicted all-cause mortality and rehospitalization for congestive heart failure. 23,27 Furthermore, urinary The Tromsø Study 1994-1995. All models were adjusted for gender, age, systolic blood pressure, current use of antihypertensive medication, body mass index, serum cholesterol, HDL cholesterol and high-sensitive CRP, current smoking, diabetes, hard physical activity $1 hour per week, eGFR, and log urinary albumin/ creatinine ratio.…”

Section: Discussionmentioning

confidence: 99%

N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population

Solbu

Toft

Løchen

et al. 2016

Journal of the American Society of Nephrology

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Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetylb-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular risk factors and the longitudinal associations between NAG, cardiovascular disease, and all-cause mortality in a general population. Urinary NAG/creatinine ratio (NAG ratio) and albumin/creatinine ratio (ACR) were measured in 6834 participants of the Tromsø Study in 1994-1995. During the median 17.5 years of follow-up, 958 myocardial infarctions, 726 ischemic strokes, and 2358 deaths were registered. In multivariable analyses adjusted for albuminuria and cardiovascular risk factors, a baseline NAG ratio in the highest quartile was associated with an increased risk of myocardial infarction (hazard ratio [HR], 1.43; 95% confidence interval [95% CI], 1.16 to 1.76), ischemic stroke (HR, 1.41; 95% CI, 1.10 to 1.80), and all-cause mortality (HR, 1.60; 95% CI, 1.39 to 1.84). Combined, ACR and NAG ratio above median associated with a 48%-80% increased risk for the three end points. However, the NAG ratio did not add significantly to the baseline risk-prediction models when assessed by area under the receiver operating characteristics curve or net reclassification improvement. In conclusion, the nonsignificant improvement of risk prediction does not support the clinical use of NAG ratio in cardiovascular risk assessment in a low-risk group.

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“…Many tissue-and/or serum-derived biomarkers are known to have important clinical applications for monitoring the severity of disease and prognostication [17][18][19] . Although numerous serum biomarkers are independently predictive of the prognostic outcomes in patients with cardiovascular disease or CKD [20][21][22][23] , few such markers are applicable in cases of CRS 24) . Microparticles (MPs), small membrane-enclosed vesicles ranging in size from 0.1 m to 1.0 m, are derived from the plasma membrane and released by activated and/or apoptotic cells.…”

Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31 CD42b AN V ) and platelet-derived apoptotic microparticles (PDA-MPs; CD31 CD42b AN V ) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CAD CKD ) and 10 patients without CAD and CKD were enrolled into group 3 (CAD CKD ). Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p 0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p 0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p 0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p 0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p 0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p 0.033). Conclusions:The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD. J Atheroscler Thromb, 2015; 22: 247-256.

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Kidney injury molecule‐1 and N‐acetyl‐ß‐d‐glucosaminidase in chronic heart failure: possible biomarkers of cardiorenal syndrome

Cited by 122 publications

References 26 publications

Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery

Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery

N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

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