Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients

García-León, Juan Antonio; Pinto-Medel, María Jesús; García-Trujillo, Lucía; Lopez‐Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández-Fernández, Óscar; Leyva, Laura

doi:10.1016/j.molimm.2011.05.018

Cited by 36 publications

(21 citation statements)

References 37 publications

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“…The KIR genes have been considered potentially important in susceptibility to infection and autoimmune diseases [19]. The associations between KIR genes and autoimmune diseases have been widely reported, such as rheumatoid arthritis (RA) [20][21][22], ankylosing spondylitis (AS) [23,24], systemic lupus erythematosus (SLE) [25], psoriasis [26,27], pemphigus foliaceus [28], scleroderma [25], multiple sclerosis [29], diabetes [30], etc. Plentiful case-control studies have investigated the association between these KIR gene polymorphisms and RA risk, but findings are not always consistent [14,[20][21][22][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Xia

Fan

et al. 2015

Human Immunology

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Section: Introductionmentioning

confidence: 99%

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Xia

Fan

et al. 2015

Human Immunology

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“…Hence, we compared the total number of aKIRs in individual DILI patients and controls, but did not find any significant differences in the proportion of subjects classified by aKIRs, ranging from 0 to 6 different types of activating receptors. As associations between dominant aKIR repertoires and disease susceptibility detected to date are mainly limited to autoimmune conditions, such as lupus erythematosus, Vogt–Koyanagi–Harada syndrome, multiple sclerosis, Hashimoto’s thyroiditis and autoimmune hepatitis (Hou et al, 2010; Levinson et al, 2010; García-León et al, 2011; Ashouri et al, 2014; Littera et al, 2016) a dominance of aKIR receptors may be less important in AC DILI. Nevertheless, autoimmune conditions can also be negatively associated with aKIRs as demonstrated for pemphigus foliaceus.…”

Section: Discussionmentioning

confidence: 99%

Killer Immunoglobulin-Like Receptor Profiles Are not Associated with Risk of Amoxicillin-Clavulanate–Induced Liver Injury in Spanish Patients

et al. 2016

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Natural killer cells are an integral part of the immune system and represent a large proportion of the lymphocyte population in the liver. The activity of these cells is regulated by various cell surface receptors, such as killer Ig-like receptors (KIR) that bind to human leukocyte antigen (HLA) class I ligands on the target cell. The composition of KIR receptors has been suggested to influence the development of specific diseases, in particularly autoimmune diseases, cancer and reproductive diseases. The role played in idiosyncratic drug-induced liver injury (DILI) is currently unknown. In this study, we examined KIR gene profiles and HLA class I polymorphisms in amoxicillin-clavulanate (AC) DILI patients in search for potential risk associations. One hundred and two AC DILI patients and 226 controls were genotyped for the presence or absence of 16 KIR loci, including the two pseudogenes 2DP1 and 3DP1. No significant differences were found in the distribution of individual KIRs between patients and controls, which were comparable to previously reported KIR data from ethnically similar cohorts. The 21.6 and 21.2% of the patients and controls, respectively, were homozygous haplotype A carriers, while 78.4 and 78.8%, respectively, contained at least one B haplotype (Bx). The genotypes translated into 27 (AC DILI) and 46 (controls) different gene profiles, with 19 being present in both groups. The most frequent Bx gene profile containing KIRs 2DS2, 2DL2, 2DL3, 2DP1, 2DL1, 3DL1, 2DS4, 3DL2, 3DL3, 2DL4, and 3PD1 was present in 16% of the DILI patients and 14% of the controls. The distribution of HLA class I epitopes did not differ significantly between AC DILI patients and controls. The most frequent receptor-ligand combinations in the DILI patients were 2DL3 + epitope C1 (67%) and 3DL1 + Bw4 motif (67%), while 2DL1 + epitope C2 (69%) and 3DL1 + Bw4 motif (69%) predominated in the controls. This is to our knowledge the first analysis of KIR receptor-HLA ligand associations in DILI, although our findings do not support evidence of these genetic variations playing a major role in AC DILI development.

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“…KIRs are found primarily on NK cells, but also on some T cell subsets, and regulate the killing function of these cells through the interaction of stimulatory or inhibitory KIRs with specific class I HLA molecules (Kaur et al 2013;Uhrberg 2005). Several recent studies have started to investigate the relationship of expression of specific KIRs in MS; thus far, each group has reported differences in one or the other of the KIRs in MS patients compared to healthy controls (Fusco et al 2010;Garcia-Leon et al 2011;Jelcic et al 2012;Lorentzen et al 2009), or in patients who make positive response to IFN-β, compared to those who don't (Martinez-Rodriguez et al 2010, 2011, but there is currently little consensus between studies. For many of the KIRs, the class I HLA ligands are still unknown, so this is an area where there is still much work to be done.…”

Section: Interaction Of Class I Hla With Kirsmentioning

confidence: 99%

The Role of HLA in MS Susceptibility and Phenotype

Greer

2014

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

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One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25-30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.

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Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients

Cited by 36 publications

References 37 publications

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Killer Immunoglobulin-Like Receptor Profiles Are not Associated with Risk of Amoxicillin-Clavulanate–Induced Liver Injury in Spanish Patients

The Role of HLA in MS Susceptibility and Phenotype

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