Although parallel manipulators (PMs) started with the introduction of architectures with 6 Degrees of Freedom (DoF), a vast number of applications require less than 6 DoF. Consequently, scholars have proposed architectures with 3 DoF and 4 DoF, but relatively few 4 DoF PMs have become prototypes, especially of the two rotation (2R) and two translation (2T) motion types. In this paper, we explain the mechatronics design, prototype and control architecture design of a 4 DoF PM with 2R2T motions. We chose to design a 4 DoF manipulator based on the motion needed to complete the tasks of lower limb rehabilitation. To the author's best knowledge, PMs between 3 and 6 DoF for rehabilitation of lower limb have not been proposed to date. The developed architecture enhances the three minimum DoF required by adding a 4 DoF which allows combinations of normal or tangential efforts in the joints, or torque acting on the knee. We put forward the inverse and forward displacement equations, describe the prototype, perform the experimental setup, and develop the hardware and control architecture. The tracking accuracy experiments from the proposed controller show that the manipulator can accomplish the required application.