Untitled

Abstract

Copper(II) alpha,omega-dicarboxylate complexes of general formulae, [Cu(O2C(CH2)nCO2)].xH2O, [Cu(O2C(CH2)nCO2) (phen)2].xH2O and [Cu(O2C(CH2),CO2)(bipy)y].xH2O (n = 1-8; y = 1, 2; phen = 1,10-phenanthroline; bipy = 2,2'-bipyridine) were synthesised. These copper complexes, some related manganese(II) complexes and the metal-free ligands were screened in vitro for their ability to inhibit the growth of Candida albicans. Metal-free 1,10-phenanthroline and all of the copper(II) and manganese(II) phenanthroline complexes were potent growth inhibitors, with only one bipyridine complex, [Cu(O2C(CH2)CO2)(bipy)2].2H2O, having moderate activity. The remaining substances were effectively inactive. Complexes which were active against C. albicans also proved effective against C. glabratta, C. tropicalis and C. kreusi with the manganese complexes retaining superior activity. For the phenanthroline complexes the active drug species is thought to be the dication [M(phen)2(H2O)n]2+ (M = Cu, Mn). Escherichia coli and Staphylococcus aureus were resistant to all of the metal complexes and also to metal-free 1,10-phenanthroline. Only the copper phenanthroline complexes showed intermediate activity against Pseudomonas aeruginosa.

Insights Into the Mode of Action of the Anti‐Candida Activity of 1,10‐Phenanthroline and its Metal Chelates

“…23 In addition, the present study has shown that the simple metal malonates (metal Mn(II), Co(II), Ni(II), Cu(II), Zn(II)) and Ni(CH3CO2)2.4H20 also have negligible activity against the yeast.…”

Synthesis, structure and anti-fungal activity of dimeric Ag(I) complexes containing bis-imidazole ligands

“…Acrylonitrile (3.6 g, 67 mmol) was added to a mixture of 2-BIM (5.0 g, 34 mmol), and triethylamine (6.8 g, 67 mmol) in acetonitrile (150 cm 3 ). The reaction mixture was refluxed with stirring for 5 h. The solvent was removed under reduced pressure giving a white solid, which was recrystallised from acetone.…”

“…In our efforts to develop new metal complexes that would greatly inhibit the growth of the human fungal pathogen Candida albicans [1][2][3][4] we have found that, to date, the most active drug tested in aqueous media is the Ag(I) complex [Ag(phendio) 2 ]ClO 4 (phendio ¼ 1,10-phenanthroline-5,6-dione) [5]. As part of these ongoing studies into the synthesis and in vitro testing of new metalbased anti-fungal drugs we report here the preparation of five Ag(I) complexes containing bis(imidazole) ligands.…”

Synthesis, antimicrobial activity and chemotherapeutic potential of inorganic derivatives of 2-(4′-thiazolyl)benzimidazole{thiabendazole}: X-ray crystal structures of [Cu(TBZH)2Cl]Cl·H2O·EtOH and TBZH2NO3 (TBZH=thiabendazole)

“…Recently, we have shown that a range of carboxylate and dicarboxylate complexes incorporating transition metal centres and including the N,N 0 -donor ligand 1,10-phenanthroline (phen) are potent in vitro inhibitors of the growth of C. albicans [10][11][12][13][14][15][16].…”