Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication

Sasaki, Reina; Masuzaki, Ryota; Matsumoto, Naoki; Okamoto, Hiroaki; Moriyama, Mitsuhiko

doi:10.3390/ijms22147420

Cited by 9 publications

(9 citation statements)

References 44 publications

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“…The suppression of La by specific small interfering RNAs (siRNAs) or by janus kinase (JAK) inhibitors (AZD1480, SD-1029, and AG490) leads to the efficient inhibition of HAV replication through the inhibition of HAV internal ribosomal entry-site (IRES) [113,114]. Recent studies have also demonstrated the ability of zinc compounds [115][116][117] and the enzyme heme oxygenase-1 (HO-1) [118], a stress-inducible heat shock protein, to inhibit viral replication in cell culture.…”

Section: Research On Hav Antiviral Treatmentmentioning

confidence: 99%

Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment

Migueres

Lhomme

Izopet

2021

Viruses

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The hepatitis A virus (HAV) is a leading cause of acute viral hepatitis worldwide. It is transmitted mainly by direct contact with patients who have been infected or by ingesting contaminated water or food. The virus is endemic in low-income countries where sanitary and sociodemographic conditions are poor. Paradoxically, improving sanitary conditions in these countries, which reduces the incidence of HAV infections, can lead to more severe disease in susceptible adults. The populations of developed countries are highly susceptible to HAV, and large outbreaks can occur when the virus is spread by globalization and by increased travel and movement of foodstuffs. Most of these outbreaks occur among high-risk groups: travellers, men who have sex with men, people who use substances, and people facing homelessness. Hepatitis A infections can be prevented by vaccination; safe and effective vaccines have been available for decades. Several countries have successfully introduced universal mass vaccination for children, but high-risk groups in high-income countries remain insufficiently protected. The development of HAV antivirals may be important to control HAV outbreaks in developed countries where a universal vaccination programme is not recommended.

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Section: Research On Hav Antiviral Treatmentmentioning

confidence: 99%

Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment

Migueres

Lhomme

Izopet

2021

Viruses

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“…MP2K3 is a bispecific kinase belonging to the MAP kinase family. It is activated by inflammation and endoplasmic reticulum stress, phosphorylates and activates the 38 mitogen-activated protein kinase axis, and participates in cell growth, differentiation, apoptosis, movement, and inflammation ( 23 ). In addition, studies have shown that MP2K3 may also be involved in the EMT of primary tumor cells ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

Proteomics comparison between mass-like and non-mass-like breast lesions

Li¹,

Wang²,

Li³

et al. 2023

Ann Transl Med

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Background The proteomic differences between mass-like (ML) breast lesions and non-mass-like (NML) breast lesions were compared to explore the formation mechanism of NML ultrasonic morphological characteristics. Methods From January to August 2021, tissue samples were collected from 10 patients with malignant ML (MML), 10 patients with malignant NML (MNML), 10 patients with benign ML (BML), and seven patients with benign NML (BNML). The proteomic differences between the BML and BNML groups and the MML and MNML groups were compared by data-independent acquisition (DIA) quantitative mass spectrometry. The differentially expressed proteins were analyzed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) networks analyses. Results We identified a total of 623 significantly differentially expressed proteins in the MML/MNML group, and 167 significantly differentially expressed proteins in the BML/BNML group, with relative ratios >1.2 or <−0.83. The up-regulated differential proteins were more abundant in the tumor necrosis factor (TNF) signaling pathway in both the MML/MNML and BML/BNML groups, suggesting that the TNF signaling pathway may be related to the ultrasonic morphological characteristics of breast lesions. Dual specificity mitogen-activated protein kinase 3 (MP2K3), a protein factor in the TNF signaling pathway, exhibited significant upregulation in both the malignant and BML groups. Conclusions The TNF signaling pathway may be associated with the ultrasonic morphological characteristics of breast lesions. MP2K3 is the up-regulated differential expression protein in the MML/MNML and BML/BNML groups, which may be related to the ultrasonic morphological characteristics of breast lesions.

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“…Inflammation and endoplasmic reticulum (ER) stress stimulate MAPK3, which phosphorylates and triggers p38 MAPK. Insulin could also activate MAPK3, which is necessary for glucose transporter expression [ 66 ]. Zinc sulfate is more likely to boost the anti-HAV action related to interferon-alpha-2a, whereas zinc chloride significantly improves it.…”

Section: Hav Ratementioning

confidence: 99%

Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination

Gholizadeh

Akbarzadeh

Hashemi

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Hepatitis A virus (HAV) is one of the well-known viruses that cause hepatitis all around the globe. Although this illness has decreased in developed countries due to extensive immunization, numerous developing and under-developed countries are struggling with this virus. HAV infection can be spread by oral-fecal contact, and there are frequent epidemics through nutrition. Improvements in socioeconomic and sanitary circumstances have caused a shift in the disease’s prevalence worldwide. Younger children are usually asymptomatic, but as they become older, the infection symptoms begin to appear. Symptoms range from slight inflammation and jaundice to acute liver failure in older individuals. While an acute infection may be self-limiting, unrecognized persistent infections, and the misapplication of therapeutic methods based on clinical guidelines are linked to a higher incidence of cirrhosis, hepatocellular carcinoma, and mortality. Fortunately, most patients recover within two months of infection, though 10–15% of patients will relapse within the first six months. A virus seldom leads to persistent infection or liver damage. The mainstay of therapy is based on supportive care. All children from 12–23 months, as well as some susceptible populations, should receive routine vaccinations, according to the Centers for Disease Control and Prevention and the American Academy of Pediatrics. Laboratory diagnosis of HAV is based on antigen detection, checking liver enzyme levels, and antibody screening. Furthermore, polymerase chain reaction (PCR) technology has identified HAV in suspected nutrition sources; therefore, this technique is used for preventative measures and food-related laws.

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Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication

Cited by 9 publications

References 44 publications

Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment

Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment

Proteomics comparison between mass-like and non-mass-like breast lesions

Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination

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