Labelling of a pyrazole derivative with 131I and investigation of its radiopharmaceutical potential

Kurtdede, Esra; Bildirici, İshak; Enginar, Hüseyin; Şener, Ahmet

doi:10.1007/s11434-013-5832-0

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…In the study reported by Kurtdede et al., 131 I‐labeled 4‐benzoyl‐1‐(4‐carboxyphenyl)‐5‐phenyl‐1H‐pyrazole‐3‐carboxylic acid (P3CA) was studied, and in vivo studies were performed on Albino Wistar rats. According to the results, the maximum uptake of 131 I‐P3CA was seen in lungs, stomach, and spleen at 15 min . Haque et al.…”

Section: Resultsmentioning

confidence: 89%

Synthesis and investigation of anticancer potential of radiolabeled naphthalene monoimide bearing imidazolium salt

et al. 2017

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Imidazolium salts and derivatives have antitumor efficacy and toxic effects in different micro-organisms. In this study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using I radionuclide. The yield of radiolabeling was determined as 98.5 ± 0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35, 20, 10, and 1 μm for HEK-293, PC-3, CaCo-2, and MCF-7 cells, respectively. In addition, the intracellular uptake of I-NMI was investigated in the cell lines, and the uptake was significantly found as 4 hr for MCF-7 and 6 hr for PC-3. In future studies, antitumor efficacy of I-NMI on tumor-bearing animal model might be studied in light of these results.

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Section: Resultsmentioning

confidence: 89%