Lack of an association between carcinoma of the stomach and the major histocompatibility complex (HLA) in Cape Coloureds

Abstract

A possible genetic contribution to the high incidence of gastric carcinoma in the Cape Coloured population of the Western Cape region of South Africa was investigated. The HLA-A, B, C, DR and DQ antigens were determined with a microcytotoxicity assay, and their frequencies compared in 124 individuals with gastric carcinoma and 4,560 controls. No significant difference was found, thus supporting the view that a genetic component has a minor, if any, role in gastric carcinogenesis.

Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans

“…However, several other studies performed in Italy, South Africa and Japan did not confirm these associations. [25][26][27] In our study reported here, the DRB1*0404 allele appeared to be significantly associated with GC incidence, suggesting that DRB1*0404 may be important in the etiology of GC among Koreans. These diverse results related to HLA associations with GC in various populations may be caused by differences in the ethnic backgrounds of the HLA allelic variations.…”

Association of HLA‐DQB1★0301 and HLA‐DQB1★0602 with Different Subtypes of Gastric Cancer in Taiwan

“…20,21,23) However, a study from South Africa by serotyping reported the lack of such an association between GC and HLA in Cape Coloureds. 22) We speculate that these conflicting results may be in part caused by differences in methodology of HLA typing and ethnic background. The genotype status of HLA may vary among different ethnic populations.…”

“…Several other studies have been conducted to investigate the relative risk of HLA class II alleles in GC in different ethnic groups. [20][21][22][23] In Caucasians, Lee et al 21) and Magnusson et al 20) have reported that HLA-DQB1 * 0301 and -DRB1 * 1601 are the principal susceptibility alleles for GC. Ohmori et al have shown a slightly different frequency of DQB1 * 0503 between GC patients and controls among Japanese.…”

“…[16][17][18][19][20] Moreover, the presence of particular alleles, DQB1 * 0301 and DRB1 * 1601, has been reported to be associated with increased risk of GC in Caucasian patients. 20,21) Nevertheless, conflicting results exist for HLA association with GC, 22,23) possibly because of differences in ethnic background and methodology, as well as disease heterogeneity. 24) To further elucidate the role of HLA in gastric carcinogenesis, we investigated the association between HLA polymorphism and GC with respect to H. pylori infection and clinical phenotype in the Taiwanese population.…”

Distribution of HLA Tissue Groups in Patients with Gastric Cancer

“…Moreover, the positive association of HLA-DR3 in gastric cancer patients from Andhra Pradesh, India was reported by Jayanthi [19]. On the other hand, many studies have determined only a poor association or no significant association between HLA and gastric cancer [20,21]. We also have demonstrated that there are no significant differences between frequencies of HLA-A, -B, -DQ and gastric cancer in the Turkish population (data not shown).…”