Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection

Abstract

Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. In a case-control setting, we investigated the association of MBL2 functional polymorphisms with Human Papillomas Virus (HPV) infection. No differences between cases (HPV(+)) and controls (HPV(-)) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV(-) groups.

MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

“…The relative weakness of MBL2 association to HPV infection could contribute to explain the difference between our findings and those of Parrella et al [18], who demonstrated a lack of association between MBL2 SNPs and HPV infection in Italian women.…”

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

“…Our findings are not in agreement with those obtained by Parrella et al [15], who did not find any correlation between genetic variants in the MBL2 gene and susceptibility to HPV infection. It should be noted, however, that Parrella et al analyzed a group of patients with a different ethnic background (Caucasian) from our study population (Brazilian) and that their MBL2 genotype and allelic frequencies were quite different from those reported in the NCBI database for the Caucasian population.…”

“…Several reports suggest that MBL can also modulate the disease severity and can be used as a marker to predict the therapeutic efficacy in some disorders, such as the response to interferon treatment in patients with chronic hepatitis C [14]. To our knowledge only one recent paper has investigated a possible correlation between MBL2 functional polymorphisms and susceptibility to HPV infection, reporting negative findings and the lack of an association [15].…”

MBL serum concentration in women with HPV presenting CIN III lesions

“…There are only few reports regarding the association between HPV and MBL [9][10][11][12]. Some authors showed that certain polymorphisms in the MBL2 gene were associated with higher susceptibility to infection by high-risk HPV genotypes [10][11][12].…”