Laser Nitriding of the Newly Developed Ti-20Nb-13Zr at.% Biomaterial Alloy to Enhance Its Mechanical and Corrosion Properties in Simulated Body Fluid

Hussein, M.A.; Kumar, A. Madhan; Yilbaş, Bekir Sami; Al-Aqeeli, N.

doi:10.1007/s11665-017-2955-5

Cited by 25 publications

(7 citation statements)

References 74 publications

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“…Robin et al [36] showed that the corrosion resistance of Ti-13Nb-13Zr alloy is a little higher than Ti-5Nb-13Zr and Ti-20Nb-13Zr alloys in the Ringer's solution excluding fluorides, and discussed that this is due to the lower Nb content of α-phase in Ti-13Nb-13Zr. In a TNZ system, Nb and Zr encourage the suppression of O 2 evolution and cease the cathodic electron transfer reaction and can lower the active anodic dissolution reactions in the system [108]. Huang et al [109] compared two alloys of Ti-13Nb-13Zr and Ti-15Mo, and concluded that Ti-13Nb-13Zr has a superior anticorrosion performance because of the Nb alloying element which annihilates the anion vacancies in the crystal lattice of the TiO 2 passive layer, which is due to the formation of covalent bonds among Nb, Zr and Ti (4d3, 4d2, 3d2) respectively [66].…”

Section: Chemical Compositionmentioning

confidence: 99%

On the Corrosion Behaviour of Low Modulus Titanium Alloys for Medical Implant Applications: A Review

Afzali

Ghomashchi

Oskouei

2019

Metals

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The corrosion behaviour of new generation titanium alloys (β-type with low modulus) for medical implant applications is of paramount importance due to their possible detrimental effects in the human body such as release of toxic metal ions and corrosion products. In spite of remarkable advances in improving the mechanical properties and reducing the elastic modulus, limited studies have been done on the electrochemical corrosion behaviour of various types of low modulus titanium alloys including the effect of different beta-stabilizer alloying elements. This development should aim for a good balance between mechanical properties, design features, metallurgical aspects and, importantly, corrosion resistance. In this article, we review several significant factors that can influence the corrosion resistance of new-generation titanium alloys such as fabrication process, body electrolyte properties, mechanical treatments, alloying composition, surface passive layer, and constituent phases. The essential factors and their critical features are discussed. The impact of various amounts of α and β phases in the microstructure, their interactions, and their dissolution rates on the surface passive layer and bulk corrosion behaviour are reviewed and discussed in detail. In addition, the importance of different corrosion types for various medical implant applications is addressed in order to specify the significance of every corrosion phenomenon in medical implants.

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Section: Chemical Compositionmentioning

confidence: 99%

On the Corrosion Behaviour of Low Modulus Titanium Alloys for Medical Implant Applications: A Review

Afzali

Ghomashchi

Oskouei

2019

Metals

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“…Therefore, the addition of metals like Nb and Zr reduce the release of metals because their oxides are less soluble in physiological fluids than oxides formed from aluminum and vanadium [ 40 ]. From literature, the TiNbZr alloy showed better corrosion resistance than commercial Ti, CP, and TiAlV [ 41 , 42 ], and Ti-Mo and TiAlNb alloys in physiological mediums [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Corrosion and In Vitro Bioactivity of Nano-Grained Biomedical Ti-20Nb-13Zr Alloy in a Simulated Body Fluid

et al. 2017

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The bioactivity and the corrosion protection for a novel nano-grained Ti-20Nb-13Zr at % alloy were examined in a simulated body fluid (SBF). The effect of the SPS’s temperature on the corrosion performance was investigated. The phases and microstructural details of the developed alloy were analyzed by XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy), and TEM (Transmission Electron Microscope). The electrochemical study was investigated using linear potentiodynamic polarization and electrochemical impedance spectroscopy in a SBF, and the bioactivity was examined by immersing the developed alloy in a SBF for 3, 7, and 14 days. The morphology of the depositions after immersion was examined using SEM. Alloy surface analysis after immersion in the SBF was characterized by XPS (X-ray Photoelectron Spectroscopy). The results of the bioactivity test in SBF revealed the growth of a hydroxyapatite layer on the surface of the alloy. The analysis of XPS showed the formation of protective oxides of TiO2, Ti2O3, ZrO2, Nb2O5, and a Ca3(PO4)2 compound (precursor of hydroxyapatite) deposited on the alloy surface, indicating that the presented alloy can stimulate bone formation. The corrosion resistance increased by increasing the sintering temperature and the highest corrosion resistance was obtained at 1200 °C. The improved corrosion protection was found to be related to the alloy densification. The bioactivity and the corrosion resistance of the developed nanostructured alloy in a SBF renders the nanostructured Ti-20Nb-13Zr alloy a promising candidate as an implant material.

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“…Albertini et al [12] showed in an in vivo study that P. arginosa and S. aureus can be observed on titanium surfaces, and they believe that these microorganisms may be associated with implant failure. Some studies have shown TiNbZr as a good option due to its excellent mechanical, bioactivity, and corrosion protection [58,59]. Compared with pure titanium and zirconia, this alloy had more potential to avoid P. arginosa and S. aureus.…”

Section: Discussionmentioning

confidence: 99%

Biological and microbiological interactions of Ti-35Nb-7Zr alloy and its basic elements on bone marrow stromal cells: good prospects for bone tissue engineering

et al. 2020

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Background An effective biomaterial for bone replacement should have properties to avoid bacterial contamination and promote bone formation while inducing rapid cell differentiation simultaneously. Bone marrow stem cells are currently being investigated because of their known potential for differentiation in osteoblast lineage. This makes these cells a good option for stem cell-based therapy. We have aimed to analyze, in vitro, the potential of pure titanium (Ti), Ti-35Nb-7Zr alloy (A), niobium (Nb), and zirconia (Zr) to avoid the microorganisms S. aureus (S.a) and P. aeruginosa (P.a). Furthermore, our objective was to evaluate if the basic elements of Ti-35Nb-7Zr alloy have any influence on bone marrow stromal cells, the source of stem cells, and observe if these metals have properties to induce cell differentiation into osteoblasts. Methods Bone marrow stromal cells (BMSC) were obtained from mice femurs and cultured in osteogenic media without dexamethasone as an external source of cell differentiation. The samples were divided into Ti-35Nb-7Zr alloy (A), pure titanium (Ti), Nb (niobium), and Zr (zirconia) and were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). After predetermined periods, cell interaction, cytotoxicity, proliferation, and cell differentiation tests were performed. For monotypic biofilm formation, standardized suspensions (106 cells/ml) with the microorganisms S. aureus (S.a) and P. aeruginosa (P.a) were cultured for 24 h on the samples and submitted to an MTT test. Results All samples presented cell proliferation, growth, and spreading. All groups presented cell viability above 70%, but the alloy (A) showed better results, with statistical differences from Nb and Zr samples. Zr expressed higher ALP activity and was statistically different from the other groups (p < 0.05). In contrast, no statistical difference was observed between the samples as regards mineralization nodules. Lower biofilm formation of S.a and P.a. was observed on the Nb samples, with statistical differences from the other samples. Conclusion Our results suggest that the basic elements present in the alloy have osteoinductive characteristics, and Zr has a good influence on bone marrow stromal cell differentiation. We also believe that Nb has the best potential for reducing the formation of microbial biofilms.

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Laser Nitriding of the Newly Developed Ti-20Nb-13Zr at.% Biomaterial Alloy to Enhance Its Mechanical and Corrosion Properties in Simulated Body Fluid

Cited by 25 publications

References 74 publications

On the Corrosion Behaviour of Low Modulus Titanium Alloys for Medical Implant Applications: A Review

On the Corrosion Behaviour of Low Modulus Titanium Alloys for Medical Implant Applications: A Review

Electrochemical Corrosion and In Vitro Bioactivity of Nano-Grained Biomedical Ti-20Nb-13Zr Alloy in a Simulated Body Fluid

Biological and microbiological interactions of Ti-35Nb-7Zr alloy and its basic elements on bone marrow stromal cells: good prospects for bone tissue engineering

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