Lead acetate induced oxidative stress and its possible reversal by Tribulus terrestris root extract in testes of Swiss albino mice

Khairwal, Vishavjeet

doi:10.9790/2402-0637985

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…85 Rich phenolic compounds present in Tribulus terrestris root extract and vitamin C have preventive role against lead acetate induced testicular toxicity in mice. 86 Phenolic compounds of Nigella sativa reported improvement against lead induced reproduction toxicity. 87…”

Section: Effect Of Polyphenol Against Lead Induced Reproductive Toxicitymentioning

confidence: 99%

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Bhattacharjee¹,

Kulkarni²,

Habbu³

et al. 2018

Int. Res. J. Pharm.

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Lead is having wide application in day to day life such as building materials, , and sea fish are also commonly intoxicated by lead. Direct or edible exposure of lead is the very common cause of lead toxicity. Chronic toxicity associated with lead is more hazardous compared to acute toxicity. Young children are especially vulnerable to the harmful effects of lead and can suffer from permanent adverse health effects, particularly affecting the brain and nervous system development. Lead causes longterm toxicity in adults, including increased risk of hypertension and kidney damage. Exposure to high lead in pregnant women levels can cause miscarriage, stillbirth, premature birth, low birth weight and minor malformations. Lead is responsible for generation of free radicals which induces a broad range of physiological, biochemical and behavioral dysfunctions. Lead exposure is having detrimental effects on almost all the major organ system which is a major contributory factor for incremental mortality and morbidity. Beneficial effects of polyphenol in lead induced toxicity have been noticed. The probable reason by which it may show the protection is scavenging of reactive oxygen species, generated by lead. Moreover, it is reported that they are also responsible for detoxification by removal of accumulated heavy metals from major organs.

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Section: Effect Of Polyphenol Against Lead Induced Reproductive Toxicitymentioning

confidence: 99%

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Bhattacharjee¹,

Kulkarni²,

Habbu³

et al. 2018

Int. Res. J. Pharm.

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show abstract

“…Tribulus terrestris extract at dose 10 mg/kgbw for 14days shown to induce follicular growth and formation of corpus luteum which led to early onset of puberty (Esfandiari et al, 2011). Root extracts of Tribulus terrestris shown to possess hormone regulatory activity wherein, its exposure ameliorated the changes induced by lead toxicity in testes of mice and showed significant improvement in serum testosterone, FSH and LH (Khairwal et al, 2015). Handfull of studies proved that Tribulus terrestris has an ability to improve reproductive function by increasing the concentration of hormones such as estradiol, testosterone (Tomova and Gyulemetova, 1978;Gauthaman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Efficacy Of Tribulus Terrestris Fruit Extract On Female Reproductive Hormones: An Interactive Study Of Co-Induced Diabetes And Cold Stress

2023

IJETMS

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Diabetes existed as a global disease and people residing in cold temperature areas encounter synergetic effects resulting in exacerbation of diabetic impediments. In view of dearth in literature with respect to its synergistic actions, this study was intended to discover an interactive effect of co-induced diabetes and cold stress on female rat reproductive hormones and also to assess ameliorative role of both Tribulus terrestris fruit (TTF) extract. STZ induced (45mg/kg bw) diabetic rats were exposed to cold stress 4±2ºC to explore the alterations in female reproductive hormones. A group of experimental rats were supplemented with TTF and extract individually at doses of 150, 200, 250 mg/kg bw for 19 days respectively. Significant alterations occurred in the levels of gonadal hormones in experimental rats’ advocates exacerbation in toxicity due to cold stress. Both diabetes and cold stress alone found to decrease FSH, LH and estrogen levels significantly (P<0.05), while progesterone levels increased significantly. Contrary to supra, cold exposure to diabetic rats caused augmentations in FSH, LH and progesterone levels with decreased estrogen levels. Supplementation of both TTF extract was found to be advantageous in reinstating the altered gonadal hormones as witnessed in cold stressed diabetic rats. The ameliorative efficacy of phytoextract could be due to the additive/individual ability of polyphenols, flavonoids and steroidal saponins which are known for hormone regulatory actions and also antidepressant actions suggesting their therapeutic role in both cold stressed and diabetic population.

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“…Tribulus terrestris L. (Zygophyllaceae) is native to India and is already found in various regions around the world because it is suited to warm regions (Ghanbari et al, 2016;Khairwal & Kumar, 2013). Its fruit has been used in traditional medicine in China and India (Ayurveda) for hundreds of years in the treatment of infertility, impotence, erectile dysfunction, and low libido.…”

Section: Introductionmentioning

confidence: 99%

Preparações de frutas Tribulus terrestris afetam os perfis químicos de HPLC e as atividades antioxidantes, lipoxigenase e inibidoras de α-glucosidase

Oliveira

Pereira

Aazza³

et al. 2022

RSD

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Tribulus terrestris fruit has been used as a traditional and popular medicine for the prevention and treatment of several diseases, including sexual dysfunction, atherosclerosis and hypertension. The aim of this study was to evaluate the antioxidant, lipoxygenase and α-glucosidase inhibitory activities of an ethanol extract from Brazilian T. terrestris and its fractions sequentially partitioned into n-hexane, dichloromethane, ethyl acetate and n-butanol. The antioxidant capacities were determined by DPPH and ABTS scavenging free radicals, chelating metal ions, reducing power and total antioxidant activity by using phosphomolybdenum. High-performance liquid chromatography with diode array detection (HPLC-DAD) fingerprint analysis and quantitation of total phenolics were performed on the samples. The dichloromethane fraction showed the most complex HPLC-DAD chemical profile. The ethyl acetate and butanol fractions revealed the best phenolic compound and flavonoid recovery from T. terrestris. Concerning antioxidant activity, the ethyl acetate fraction presented better capacity for scavenging DPPH, ABTS and hydroxyl radicals, reductive power, total antioxidant capacity (TAC) and α-glucosidase inhibitory activity than the other fractions. These results correlated closely with the levels of phenolic compounds and flavonoids. The hexane fraction showed the best metal chelating power and lipoxygenase inhibitory activity. The anti-diabetic and anti-inflammatory potential of Brazilian Tribulus terrestris depend on the method of preparation.

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Lead acetate induced oxidative stress and its possible reversal by Tribulus terrestris root extract in testes of Swiss albino mice

Cited by 3 publications

References 34 publications

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Ameliorative Efficacy Of Tribulus Terrestris Fruit Extract On Female Reproductive Hormones: An Interactive Study Of Co-Induced Diabetes And Cold Stress

Preparações de frutas Tribulus terrestris afetam os perfis químicos de HPLC e as atividades antioxidantes, lipoxigenase e inibidoras de α-glucosidase

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