Left ventricular filling in young normotensive obese adults

Ku, Chang-Sheng; Lin, Shoa-Lin; Wang, Dang-Jiang; Chang, Shi-Kun; Lee, Wen-June

doi:10.1016/0002-9149(94)90347-6

Cited by 79 publications

(45 citation statements)

References 18 publications

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“…In accordance with several other reports, 9,30,[33][34][35] our data suggest that the diastolic function of severely obese people is also markedly impaired, as in obese people early diastolic peak filling velocity is decreased and late peak velocity is higher, so the E/A ratio becomes smaller. An elongation of IVRT also suggests an impairment of the diastolic function, since heart rate was higher in the obese persons; thus, the duration of the whole cardiac cycle was shorter.…”

Section: Discussionsupporting

confidence: 93%

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Cardiac hypertrophy and diastolic function in physically well trained and in obese men

Sidó¹,

Jákó²,

Kneffel

et al. 2003

Int J Obes

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OBJECTIVE:The aim of the present study was to compare cardiac hypertrophy and diastolic function in extremely obese male patients and physically active adult male subjects of similar age (means 43.0-43.4 y). DESIGN: Data of male patients referred to our hospital ward in order to reduce their body weight (BW) were compared with those of physically active and nonactive healthy males. SUBJECTS: The groups contained 21-24 male subjects, very active and moderately active subjects taking part in regular competitive or leisure time physical activity were in the two athletic groups, severely overweight patients constituted the obese group and healthy persons served as controls. MEASUREMENTS: Two-dimensionally guided M-mode and Doppler recordings. RESULTS: In comparison with the controls, obese patients had larger left atrial systolic and left ventricular (LV) diastolic internal diameters, LV diastolic wall thickness and muscle mass. Of the body size-related indices, only the left atrial systolic diameter index was significantly higher. LV systolic and diastolic functions were impaired as indicated by a decreased ejection fraction (EF), higher heart rate (HR), decreased E/A quotient and increased isovolumetric relaxation time. In the physically very active subjects, a thicker LV diastolic wall was seen without LV dilatation. Body size-related wall thickness and muscle mass were significantly higher than in the controls. EF and HR did not differ from those of the controls. CONCLUSION: The most useful help to distinguish between physiological and pathological left ventricular hypertrophy can be to investigate diastolic functions. The most salient difference appeared in diastolic function, because E/A quotient was higher in the very active subjects than in the controls and it was the lowest in the obese persons.

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Section: Discussionsupporting

confidence: 93%

“…13,15,29 Other authors, however, reported larger LVIDD also in obese patients, indicative of the weakness and dilatation of the left ventricle rather than of a hypertrophy. 1,2,30,31 The left ventricle is presumably overloaded by the increased venous inflow, the same is reflected also by the marked dilatation of the left atrium.…”

Section: Discussionmentioning

confidence: 99%

Cardiac hypertrophy and diastolic function in physically well trained and in obese men

Sidó¹,

Jákó²,

Kneffel

et al. 2003

Int J Obes

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“…Later, other factors like left ventricular hypertrophy and diastolic dysfunction may also be responsible for increased left atrial size. 17 However, in the Strong Heart Study cohort, 18 it was observed that increases in stroke volume, cardiac output, and left ventricular mass were more closely related to the associated increase in lean body mass than to the amount of fat in obese patients. Left ventricular filling pressure increases with exercise, often to more than 20 mm Hg, even if it is normal at rest.…”

Section: Pathophysiology Of the Circulatory System In Obese Patientsmentioning

confidence: 99%

Obesity: Effects on Cardiovascular Disease and its Diagnosis

Mathew¹,

Francis²,

Kayalar³

et al. 2008

The Journal of the American Board of Family Medicine

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The higher prevalence of cardiovascular disease in obese individuals is indirectly mediated, to a large extent, by the increased frequency of various well known risk factors like hypertension, diabetes, and dyslipidemia, either individually or as part of the metabolic syndrome. However, there are several ways in which obesity directly affects the cardiovascular system; these will be discussed in detail. We also focus on various challenges posed by obesity in the performance and interpretation of cardiac investigations and how they can be addressed. (J Am Board Fam Med 2008;21:562-8.)

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“…There is an increasing prevalence of childhood obesity which is in association with left ventricular dysfunction in adults [5][6][7]. Several studies revealed that obesity, when complicated with hypertension, hyperlipidemia and insulin resistance results in cardiac dysfunction due to ventricular hypertrophy and chamber enlargement increase cardiovascular mortality and morbidity [8][9][10]. The aim of this study is to investigate the impact of uncomplicated obesity on ventricular morphology and functions in pediatric age group.…”

Section: Introductionmentioning

confidence: 99%

Çocukluk çağı obezitesinin kardiyak yapı ve fonksiyonlara etkisi

Atik¹,

Şanlı²,

Ergür³

et al. 2017

TURKISH JOURNAL of CLINICS and LABORATORY

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The aim of this study was to compare the left ventricle structure and its functions in obese children without established complications and none obese children. Material and Methods:Anthropometric and conventional echocardiographic parameters of cardiac geometry and left ventricular function were obtained in 40 obese children without any other disease and complication of obesity like hypertension, hypercholesterolemia, and a control group of 40 healthy lean. Fasting plasma glucose, insulin levels were obtained and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated.Results: Height, weight, body surface area and body mass index (BMI), were found significantly higher in the obese group (P < 0.001). Insulin and HOMA-IR scores were higher in obese group. No significant differences were observed for left ventricular systolic and diastolic diameter (P > 0.05). Left ventricular mass (LVM), LVM/ht, LVM/BMI and relative wall thickness (RWT) were significantly increased in obese children than the controls (P < 0.001) and most of them had eccentric left ventricular (LV) hypertrophy. Ejection fraction was significantly decreased seen obese group. A positive correlation was seen between BMI and LV posterior wall thickness and interventricular septal thickness (R > 0.45, P < 0.05). Both types of hypertrophy were seen in insulin resistant obese group. Conclusion:The known causes are altered homeostatic and neurohumoral mechanisms and compensation of higher metabolic demands and increased left ventricular mass, reduced myocardial performance due to hemodynamic load associated with higher cardiovascular morbidity and mortality rates.

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Left ventricular filling in young normotensive obese adults

Cited by 79 publications

References 18 publications

Cardiac hypertrophy and diastolic function in physically well trained and in obese men

Cardiac hypertrophy and diastolic function in physically well trained and in obese men

Obesity: Effects on Cardiovascular Disease and its Diagnosis

Çocukluk çağı obezitesinin kardiyak yapı ve fonksiyonlara etkisi

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