Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome

Abstract

We aimed to analyze the changes in plasma leptin, serum inflammatory factors and urinary protein in children with nephrotic syndrome before and after treatment and their clinical significance. A total of 28 children treated and diagnosed with nephrotic syndrome between November 2015 and October 2016 were selected as treatment group, while 25 healthy children were selected as control group. There were no statistically significant differences in age, sex, body mass index (BMI), serum albumin and other general data between treatment group and control group (P>0.05). There was a positive correlation between serum high-sensitivity C-reactive protein (hs-CRP) level and 24 h urinary protein level in children with nephrotic syndrome before treatment (r=0.408, P=0.005). Twenty-four hours urinary protein, urea nitrogen (BUN) and serum creatinine (SCr) levels in children with nephrotic syndrome before treatment were significantly higher than those in normal children, and these indexes were significantly decreased after treatment. The levels of plasma leptin and serum inflammatory factors (hs-CRP and IL-18) in children with nephrotic syndrome before treatment were obviously higher than those in normal children, and these indexes were obviously decreased after treatment. In conclusion, the detection of changes in plasma leptin, serum inflammatory factors (hs-CRP and IL-18) and urinary protein in children with nephrotic syndrome before and after treatment has important reference value for reflecting the severity of disease and evaluating the prognosis of children with nephrotic syndrome.

Comparison of High Sensitivity C-Reactive Protein Value for Steroid Sensitive Nephrotic Syndrome Patients With Steroid Resistant

“…12 Average age of research subjects for steroid sensitive NS patients it was 8.4 (SD 4.8) years, whereas for steroid-resistant NS it was 10.4 (SD 4.7) years. This is in accordance with the research of Zhou et al 2018, where the mean age of SN patients was 8.9 ± 1.6 years. 13 In this study, the average body weight of steroid-sensitive NS patients was 28.9 (SD 13.1) and steroid-resistant NS 37.2 (SD 16.1), while the height of each group was 123.2 (SD 24.6) and 135.8 (SD 22.7).…”

“…This is in accordance with the research of Zhou et al 2018, where the mean age of SN patients was 8.9 ± 1.6 years. 13 In this study, the average body weight of steroid-sensitive NS patients was 28.9 (SD 13.1) and steroid-resistant NS 37.2 (SD 16.1), while the height of each group was 123.2 (SD 24.6) and 135.8 (SD 22.7). In the research of Kniazewska et al in the SN patients studied, 1 patient was obese (body mass index (BMI) above the 95th percentile), 3 (10%) overweight (90-95th percentile BMI), and 2 (6.6%) with short stature (height below percentile 5).…”

Association Between Visceral Adipose Tissue and Glomerular Hyperfiltration in Adolescents: A Cross-Sectional Study

“…cause in ammation [28], and increase urinary protein levels [32]. Meanwhile, adiponectin is a protective factor that inhibits atherosclerosis [33].…”

Serum interleukin-18 in children with steroid sensitive nephrotic syndrome

“…Interleukin-18 (IL-18), a novel immunoregulatory cytokine, is a member of IL-1 cytokine superfamily, which enhances both type-1 and type-2 mediated immune responses (1,2). It plays an important role for maintaining immune system regulation (2,3). Different immunity components such as mononuclear macrophages, B cells, natural killers and other factors are responsible for synthesis and secretion of IL-18, which in turn promotes macrophages and other immunity reactions (3).…”

“…It plays an important role for maintaining immune system regulation (2,3). Different immunity components such as mononuclear macrophages, B cells, natural killers and other factors are responsible for synthesis and secretion of IL-18, which in turn promotes macrophages and other immunity reactions (3). IL-18 has an active role in various immunologic conditions such as infections, allograft rejection, and autoimmune disorders (4).…”