Leydig cell tumor of the testis, presenting with azoospermia

Hibi, Hatsuki; Yamashita, Kyoko; Sumitomo, Makoto; Asada, Yoshimasa

doi:10.1002/rmb2.12046

Cited by 6 publications

(7 citation statements)

References 6 publications

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“…However, no pronounced differences in expression of proteins studied here were found between those used for the study: tumor testicular tissues of azoospermic non-obese, and obese patients. It should be added that previously we reported increased perilipin expression and decreased steroidogenic acute regulating protein expression in these patients [27]. In addition, increased estradiol levels can reflect increased cholesterol content and/or perturbations in its processing in men with Leydig cell tumors.…”

Section: Discussionmentioning

confidence: 76%

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Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Duliban

Górowska-Wójtowicz

Tworzydło

et al. 2020

IJMS

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Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnosis, and therapy still remains not completely characterized. Our prior studies reported G-protein coupled estrogen receptor signaling and estrogen level disturbances in Leydig cell tumors. In addition, we found that expressions of multi-level-acting lipid balance- and steroidogenesis–controlling proteins including peroxisome proliferator-activated receptor are altered in this tumor. In order to get deeper into the other molecular mechanisms that regulate lipid homeostasis in the Leydig cell tumor, here we investigate the presence and expression of newly-described hormones responsible for lipid homeostasis balancing (leptin and adiponectin), together with expression of estrogen synthase (aromatase). Samples of Leydig cell tumors (n = 20) were obtained from patients (31–45 years old) and used for light and transmission electron microscopic, western blotting, and immunohistochemical analyses. In addition, body mass index (BMI) was calculated. In tumor mass, abundant lipid accumulation in Leydig cells and various alterations of Leydig cell shape, as well as the presence of adipocyte-like cells, were observed. Marked lipid content and various lipid droplet size, especially in obese patients, may indicate alterations in lipid homeostasis, lipid processing, and steroidogenic organelle function in response to interstitial tissue pathological changes. We revealed significantly increased expression of leptin, adiponectin and their receptors, as well as aromatase in Leydig cell tumors in comparison to control. The majority of patients (n = 13) were overweight as indicated by their BMI. Moreover, a significant increase in expression of phospholipase C (PLC), and kinases Raf, ERK which are part of adipokine transductional pathways, was demonstrated. These data expand our previous findings suggesting that in human Leydig cell tumors, estrogen level and signaling, together with lipid status, are related to each other. Increased BMI may contribute to certain biochemical characteristics and function of the Leydig cell in infertile patients with a tumor. In addition, altered adipokine-estrogen microenvironment can have an effect on proliferation, growth, and metastasis of tumor cells. We report here various targets (receptors, enzymes, hormones) controlling lipid balance and estrogen action in Leydig cell tumors indicating their possible usefulness for diagnostics and therapy.

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Section: Discussionmentioning

confidence: 76%

“…In histology of this tumor different morphological types of steroidogenic cells as well as other cell types were observed [26]. In addition, Hibi et al [27] reported the presence of adipocyte-like cells in tumor Leydig cell tissue.…”

Section: Introductionmentioning

confidence: 78%

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Duliban

Górowska-Wójtowicz

Tworzydło

et al. 2020

IJMS

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“…The reduction of FSH affects Sertoli cells in producing ABP or testosterone receptors [104][105][106][107][108][109][110]. LH reduction suppresses Leydig cells to produce testosterone hormones [111][112][113][114][115][116][117]. These two ingredients are very important in the development and growth of spermatozoa cells so that production interruption will reduce the production of spermatozoa cells in the testes.…”

Section: Discussionmentioning

confidence: 99%

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Ilyas

Hutahaean

Nursal

2018

Asian J Pharm Clin Res

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Objective: The discovery of male contraceptive drugs continues to be pursued, due to the very small participation of men associated with the lack of contraceptiveÐptions for men. The combination of methanol extract of bitter melon seed and depot medroxyprogesterone acetate (DMPA) becomes the choice that currently being pursued to be applied to men. Methods:The use of guinea pigs as experimental animals conducted research using experimental methods with complete randomized design. The study was divided into four control groups i.e K0; dimethylsulfoxide (DMSO) for 0 week (4 h),K1; Control group of DMSO for 4 weeks, K2; Control group of DMSO for 8 weeks, K3; Control group of DMSO for 12 weeks, and four treatment groups, i.e: group P0; bitter melon seed extract of 50 mg/100g body weight/day for 0 week (4 h), group P1; Bitter melon seed extract of 50 mg/100g BW/day for 4 weeks+DMPA, group P2; Bitter melon seed extract of 50 mg/100g BW/day for 8 weeks+DMPA, P3 group; Bitter melon seed extract of 50 mg/100g BW/day for 12 weeks+DMPA.Results: There was a significant effect (p<0.05) methanol extract of bitter melon seed to increase the transforming growth factor expression -β expression. Conclusion:The methanol extract of bitter melon seed was able to be candidate for herbal contraception.

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“…Patients may present with testicular swelling and varying levels of androgen/estrogen secretion from the tumor, possibly leading to precocious puberty, gynecomastia, decreased libido and male factor infertility. 1 Seminoma is a more common pathology, representing 55-60% of testicular malignancies. 2 However, the ipsilateral cooccurrence of the two is extremely rare, with only five reported cases to-date.…”

Section: Introductionmentioning

confidence: 99%

Case – Leydig cell hyperplasia

Bal,

Fidel,

Shah

et al. 2024

CUAJ

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Leydig cell tumor of the testis, presenting with azoospermia

Cited by 6 publications

References 6 publications

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Case – Leydig cell hyperplasia

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