Ligand dependent self-assembly of hydroxido-bridged dicopper units templated by sodium ion

Abstract

Crown-ether like interaction of two neutral [Cu2(μ-OH)(μ-L(1))] (H3L(1) = 2-(2'-hydroxyphenyl)-1,3-bis[4-(2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine) fragments, around a central Na(+) cation as self-assembly template, led to the formation of [Na{Cu2(μ-OH)(μ-L(1))}2]ClO4 (1). Di-tert-butyl group substituted H3L(2) {2-(3,5-di-tert-butyl-2-hydroxyphenyl)-1,3-bis[4-(3,5-di-tert-butyl-2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine} conversely yields only [Cu2(μ-OH)(μ-L(2))]·1.5H2O (2), by discarding aggregation around the Na(+) ion. The crown-ether type aggregate 1 exhibits ferromagnetic interactions within the double oxido-phenoxido [Cu2] fragments and weak antiferromagnetic interactions are mediated by the ONa(+)O bridges. Complex 2 registers only weak antiferromagnetic interactions within the oxido-phenoxido bridged [Cu2] entity. UV-visible and emission titration spectroscopy establish the interaction of cationic complex 1 with calf thymus DNA in Tris buffer and it cleaves supercoiled pBR322 DNA from in situ generated ROS.

A mechanistic approach for in‐vitro anticancer activity via nucleic acid fragmentation by copper(II) complex anchored on MCM‐41

“…[18,19] However, high redox activity of the free copper metal ions is highly cytotoxic, so the intracellular concentration of free copper ions must be strongly regulated, [20] otherwise large accumulation of this metal ions may lead to harmful disease like Wilson diseases. [21,22] A plenty number of copperbased complexes with various sets of Schiff ligand scaffolds have been synthesized to resolve this purpose and displayed remarkable in-vitro cytotoxicity [23][24][25][26][27][28][29] because of (a) tuneable physicochemical properties arises from infinite structural and compositional varieties of metal and ligand and (b) fast biodegradation due to the presence of labile coordination bonds, which further promotes the ease of excretion after their biofunction. [30][31][32] By surveying the literature, it is evident that there are several excellent reports based on Schiff base ligands enhance the efficacy of the metallodrug to many folds due to the presence of active C═N group in it.…”

Biological evaluation of dinuclear copper complex/dichloroacetic acid cocrystal against human breast cancer: design, synthesis, characterization, DFT studies and cytotoxicity assays

“…In vitro experiment on MCF7 (human, mammary gland, metastatic site, epithelial cell, breast cancer) cell line viz., cell proliferation, cell culture, MTT assay, AO/EB staining and ROS generation assays were carried by adopting standard methods [77][78][79] with slight modication as reported earlier by us and references therein. [80][81][82][83][84][85] The cell lines was purchased from ATCC.…”

Supramolecular architectures of mononuclear nickel(II) and homobinuclear copper(II) complexes with the 5,5′-dimethyl-2,2′-bipyridine ligand: Syntheses, crystal structures and Hirshfeld surface analyses

“…These results are comparable to those found for similar compounds. 55 Within this structure, each copper ion is in a five-coordinated CuN2O3 environment with geometries swing between the ideal square pyramidal and trigonal bipyramidal structures, this is justified by the trigonal parameter τ, τ = (β -α)/60: where α and β are the largest angles around the Cu2 + ion. We noticed that τ = 1 corresponds to a trigonal bipyramidal geometry and τ = 0 to a square pyramidal geometry.…”