Likely Common Role of Hypoxia in Driving<sup>18</sup>F-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection

Yao, Yong; Li, Yaming; He, Zuo-Xiang; Civelek, A. Cahid; Li, Xiaofeng

doi:10.1089/cbr.2020.4716

Cited by 12 publications

(12 citation statements)

References 51 publications

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“…Although 18 F-FDG is the most routinely used imaging agent in nuclear medicine, it has certain limitations regarding its diagnostic specificity, including low uptake by the liver and gastric mucinous adenocarcinoma. 1,13,14 Consequently, more targets have been developed for PET imaging. TREM2 is a single-pass membrane receptor belonging to the immunoglobulin superfamily and is primarily expressed on the surfaces of microglia and macrophages.…”

Section: ■ Discussionmentioning

confidence: 99%

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

Shi

Cheng

et al. 2023

Mol. Pharmaceutics

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Low β-2-[ 18 F]-fluoro-2-deoxy-D-glucose ( 18 F-FDG) uptake in gastric mucinous adenocarcinoma may cause false-negative diagnosis and erroneous staging. Thus, there is an urgent need for developing tumor-specific imaging agents in gastric cancer diagnostics. Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on the surface of tumor-associated macrophages (TAMs) and is considerably overexpressed in tumor tissues. This study aimed to develop new human TREM2 (hTREM2)-targeting imaging agents to diagnose and monitor gastric cancer. We established a cell line, MGC803, with upregulated expression of hTREM2, at the cell surface. We produced a monoclonal antibody (5-mAb) against hTREM2 by immunizing mice with the hTREM2 antigen to obtain the antibody fragment 5-F(ab′) 2 using an immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS). Another anti-TREM2-mAb (clone 237920) and its fragment anti-TREM2-F(ab′) 2 were employed for the comparative study in vitro and in vivo. After 124 I labeling, we constructed the probes: 124 I-5-mAb, 124 I-5-F(ab′) 2 , 124 I-anti-TREM2-mAb, and 124 I-anti-TREM2-F(ab′) 2 . We found that 5-mAb exhibited higher hTREM2 affinity and slower blood clearance than anti-TREM2-mAb, whose corresponding F(ab′) 2 fragments demonstrated the same trend. The micro-PET/CT revealed that 124 I-5-F(ab′) 2 exhibited advantages of tumor enrichment and fast metabolism. The biodistribution study results were consistent with those of micro-PET/CT. Among the four tracers, 124 I-5-F(ab′) 2 was the most suitable specific radiotracer for targeting hTREM2 and displayed potential utility as a tumor-imaging tracer for diagnosing gastric carcinoma.

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Section: ■ Discussionmentioning

confidence: 99%

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

Shi

Cheng

et al. 2023

Mol. Pharmaceutics

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“…2. Metabolic parameters for metastatic and reactive hyperplasia lymph nodes of bladder cancer in dual time point imaging Since tumors and hyperplasia may differ in the rate of uptake and excretion of FDG [12,19], delayed imaging may help differentiate lymph node reactive hyperplasia from lymph node metastases [20,21].…”

Section: Study Population and Conventional Suvmax Value For Different...mentioning

confidence: 99%

The value of dual time point 18F-FDG PET/CT imaging in differentiating lymph node metastasis from reactive hyperplasia in bladder urothelial carcinoma

Zhou

Zhang

et al. 2023

Preprint

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Purpose Our study explored the clinical value of dual time point FDG PET imaging for differentiating lymph node metastasis from lymph node reactive hyperplasia. Methods The study analyzed 250 lymph nodes from bladder cancer patients. All patients underwent 18F-FDG PET/CT delayed diuretic imaging. Metabolic parameters SUVmax, SUVmean, MTV, and related delay indices before and after PET delayed imaging were obtained. Relationships with outcomes were analyzed using nonparametric analysis and multivariate analysis. ROC curves and nomograms were drawn to predict lymph node metastasis. Results Delayed PET/CT imaging helps to detect more suspicious lymph nodes. If SUVmax = 2.0 or 2.5 was taken as cut-off, delayed imaging could increase the detection rate of metastatic lymph nodes by 4.1%, and 6.9%, respectively. Reactive hyperplasia lymph nodes were more likely to show increased lymph node-localized FDG uptake than metastatic lymph nodes on delayed FDG imaging. Metastatic lymph nodes were more likely to have whole, diffuse increased FDG uptake on delayed imaging. Short lymph node diameter, SUVmean, and DIMTV were three independent predictors for differentiating metastatic lymph nodes from reactive hyperplasia. Lymph node metastasis could be better differentiated from inflammatory hyperplasia ones by the combination of these three predictors. In high-risk patients, the probability of lymph node metastasis is as high as 97.6%. Conclusions Dual time point imaging is helpful to detect more suspicious lymph nodes. Some hyperplasic lymph nodes had certain image characteristics using delayed imaging. Short lymph node diameter, SUVmean, and DIMTV were three important parameters for predicting lymph node metastasis.

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“…18 F-FDG is an analog of glucose, with the hydroxyl at C-2 position substituted by fluorine-18. 18 F-FDG could reflect the glucose metabolism partly by responding to the hypoxia environment in some tumors, myocardial ischemia, and inflammation [160]. And as the 2-hydroxyl group is necessary for further glycolysis, 18 F-FDG phosphorylated cannot be metabolized and is trapped in the cell until radioactive decay [161].…”

Section: Glucose Metabolism Imagingmentioning

confidence: 99%

PET molecular imaging for pathophysiological visualization in Alzheimer’s disease

Wang

Jin²,

Zhou³

et al. 2022

Eur J Nucl Med Mol Imaging

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Alzheimer’s disease (AD) is the most common dementia worldwide. The exact etiology of AD is unclear as yet, and no effective treatments are currently available, making AD a tremendous burden posed on the whole society. As AD is a multifaceted and heterogeneous disease, and most biomarkers are dynamic in the course of AD, a range of biomarkers should be established to evaluate the severity and prognosis. Positron emission tomography (PET) offers a great opportunity to visualize AD from diverse perspectives by using radiolabeled agents involved in various pathophysiological processes; PET imaging technique helps to explore the pathomechanisms of AD comprehensively and find out the most appropriate biomarker in each AD phase, leading to a better evaluation of the disease. In this review, we discuss the application of PET in the course of AD and summarized radiolabeled compounds with favorable imaging characteristics.

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Likely Common Role of Hypoxia in Driving¹⁸F-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection

Cited by 12 publications

References 51 publications

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

The value of dual time point 18F-FDG PET/CT imaging in differentiating lymph node metastasis from reactive hyperplasia in bladder urothelial carcinoma

PET molecular imaging for pathophysiological visualization in Alzheimer’s disease

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Likely Common Role of Hypoxia in Driving18F-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection

Cited by 12 publications

References 51 publications

124I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

124I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

The value of dual time point 18F-FDG PET/CT imaging in differentiating lymph node metastasis from reactive hyperplasia in bladder urothelial carcinoma

PET molecular imaging for pathophysiological visualization in Alzheimer’s disease

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Likely Common Role of Hypoxia in Driving¹⁸F-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma

¹²⁴I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma