Linezolid-resistant mucoid Staphylococcus haemolyticus from a tertiary-care centre in Delhi

Matlani, Monika; Shende, Trupti; Bhandari, Vasundhra; Dawar, Reetika; Sardana, Raman; Gaind, Rajni

doi:10.1016/j.nmni.2016.02.010

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…However, one thing different from the study of Luiza et al (2016) is that two (0.9%) MRSH isolates in the present study, on the contrary, showed resistance to vancomycin, the last resort of antibiotic from glycopeptides, posing a threat for the persistence and dissemination of the resistance determinants within healthcare settings. In different studies, it was reported the occurrence of MRSH isolates possessed elevating resistance to glycopeptide antibiotics, such as vancomycin (Veach et al 1990) and teicoplanin (Kristóf et al 2011) as well as linezolid (Chauhan et al 2017;Matlani et al 2016) suggesting the alarming development of MRSH resulting the treatment options to be more limited. Therefore, it is urgently needed to put more attention to the dissemination of the MRSH in the hospital environment through monitoring and surveillance programs so that the risk of infection might be reduced.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Staphylococcus haemolyticus as the most dominant species among Staphylococcal infections at the Zainoel Abidin Hospital in Aceh, Indonesia

2019

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Abstract. Suhartono S, Hayati Z, Mahmuda Mahmuda M. 2019. Distribution of Staphylococcus haemolyticus as the most dominant species among Staphylococcal infections at the Zainoel Abidin Hospital in Aceh, Indonesia. Biodiversitas 20: 2076-2080. The occurrence of Staphylococcus-related infections is emerging and might potentially harbor multidrug resistance leading to the major risks of hospital-associated infection. The study aimed to determine the dominant species distributed among Staphylococcus-related infections from clinical specimens and determine antibiotic resistance profile of the dominant species. The clinical samples were collected from inpatients and outpatients at the Zainoel Abidin Regional Hospital of Aceh, Indonesia during March 2017-March 2018. All clinical samples were mainly inoculated to plates containing blood agar followed by identification and determination of their antibiotic susceptibility using VITEK® 2 Compact. Statistical analysis was performed using Chi-square test or Fisher's exact test when appropriate to determine the independence of frequency distributions, and the tests were considered statistically significant at a P ≤ 0.05 on two-tailed. Of 693 Staphylococcus isolates found in the clinical specimens, Staphylococcus haemolyticus was the most predominant isolates with a total of 233 (32.2%), and it was identified with a high prevalence of methicillin-resistance (95.96%) termed as methicillin-resistant Staphylococcus haemolyticus (MRSH). MRSH were found in the blood samples and ICU patients accounting for 64.1% and 55.61%, respectively. The resistance profile of MRSH isolates exhibited a high level of resistance (more than 85%) to a wide range of antibiotics, including beta-lactams, (first to the fourth generation) cephalosporins, fluoroquinolones, carbapenems, and macrolides. This might be an alarming occurrence and require serious action to prevent MRSH dissemination of healthcare infections in the future.

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Section: Discussionmentioning

confidence: 99%

Distribution of Staphylococcus haemolyticus as the most dominant species among Staphylococcal infections at the Zainoel Abidin Hospital in Aceh, Indonesia

2019

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“…Some S. haemolyticus variants show a mucoid appearance. These mucoid colonies were associated with linezolid-resistant and were difficult to treat [108]. Linezolid-resistant S. haemolyticus isolates were responsible for an outbreak in an Italian intensive care unit [42].…”

Section: Linezolidmentioning

confidence: 99%

Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus

et al. 2022

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Staphylococcus haemolyticus (S. haemolyticus) constitutes the main part of the human skin microbiota. It is widespread in hospitals and among medical staff, resulting in being an emerging microbe causing nosocomial infections. S. haemolyticus, especially strains that cause nosocomial infections, are more resistant to antibiotics than other coagulase-negative Staphylococci. There is clear evidence that the resistance genes can be acquired by other Staphylococcus species through S. haemolyticus. Severe infections are recorded with S. haemolyticus such as meningitis, endocarditis, prosthetic joint infections, bacteremia, septicemia, peritonitis, and otitis, especially in immunocompromised patients. In addition, S. haemolyticus species were detected in dogs, breed kennels, and food animals. The main feature of pathogenic S. haemolyticus isolates is the formation of a biofilm which is involved in catheter-associated infections and other nosocomial infections. Besides the biofilm formation, S. haemolyticus secretes other factors for bacterial adherence and invasion such as enterotoxins, hemolysins, and fibronectin-binding proteins. In this review, we give updates on the clinical infections associated with S. haemolyticus, highlighting the antibiotic resistance patterns of these isolates, and the virulence factors associated with the disease development.

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“…Species wise susceptibility to linezolid has been reported by various workers; Kalawatet alreported LzRinS. lugdunensisand S.hominis, 6 Peer et al in S.cohnii and S.kloosii, 5 Gupta et alin S.haemolyticus 26 and recently Matlaniet al in 2016 27 reported mucoid strain of S.haemolyticus showingLzR. Such high level of resistance to linezolid is an alarm for the judicious use of this drug.…”

Section: Discussionmentioning

confidence: 93%

Linezolid Resistantclinically Significant Isolates of Coagulase Negative Staphylococci: An Emerging Therapeutic Concern

2020

IJPHRD

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Multidrug resistant Coagulase Negative Staphylococci (MDRCoNS) have emerged as a major cause of morbidity and mortality in hospital settings. A total of 706 clinically significant isolates of CoNS, were identified up to species level. Antimicrobial susceptibility testing was carried out with especial reference to linezolid and methicillin. Staphylococcus epidermidis (44.33%) was the predominant species isolated followed by Staphylococcus haemolyticus (39.37%) and Staphylococcus lugdenensis (5.24%). Isolates were predominantly recovered from blood 82.86%. Linezolid resistance (LzR) was seen in 2.54%.S. haemolyticuswas the most resistant phenotype. The LzR isolates were also methicillin resistant. MDRCoNSposes a significant therapeutic challengedemanding judicious use of antibiotics.

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Linezolid-resistant mucoid Staphylococcus haemolyticus from a tertiary-care centre in Delhi

Abstract: We report an unusual morphological mucoid variant of Staphylococcus haemolyticus associated with linezolid resistance from a patient with sepsis. Linezolid resistance and mucoid character together made this pathogen difficult to treat. To our knowledge this is the first such report.

Cited by 5 publications

References 4 publications

Distribution of Staphylococcus haemolyticus as the most dominant species among Staphylococcal infections at the Zainoel Abidin Hospital in Aceh, Indonesia

Distribution of Staphylococcus haemolyticus as the most dominant species among Staphylococcal infections at the Zainoel Abidin Hospital in Aceh, Indonesia

Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus

Linezolid Resistantclinically Significant Isolates of Coagulase Negative Staphylococci: An Emerging Therapeutic Concern

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