Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate

Minh, Thuy Doan; Ha, Tuan Nguyen Thanh; Duy, Thuan Nguyen; Hoang, Ngan Nguyen; PhamTien, Dung; Thai, Hung Pham; Thi, Hoa Nguyen; Lan, Phuong Dang Thi; Quoc, Binh Pham; Ивкин, Д. Ю.; Повыдыш, М. Н.; Cong, Bang Nguyen; Краснова, М. В.

doi:10.1016/j.jep.2021.114388

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Administration of T undecanoate showed dose-dependently increased levels of testosterone, DHT and in 5-alpha reductase; based on the changes in DHT-related markers, the dosage thought to be effective for repeated administration was reviewed. Additionally, we measured prostate measurements and epithelial thickness, which are major markers associated with enlargement of prostate tissue [ 29 , 30 ], to conform whether it affects the prostate level even after a long period of time after a single administration. The increasing epithelial thickness is well known feature of BPH [ 29 – 31 ], and it was confirmed concentration-dependently increases in exogenous testosterone administrated groups.…”

Section: Discussionmentioning

confidence: 99%

Comparative application of testosterone undecanoate and/or testosterone propionate in induction of benign prostatic hyperplasia in Wistar rats

Kong

2022

PLoS ONE

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Testosterone undecanoate is a hormone agent with long-acting potential and is used for testosterone replacement therapy for hypogonadism. This study was designed to investigate application of testosterone undecanoate in maintaining high androgen levels for inducing benign prostatic hyperplasia more conveniently than that for testosterone propionate. We conducted two-part studies to determine the optimal dosage and dosing cycle for efficient and stable induction of benign prostatic hyperplasia using testosterone undecanoate. In the injection dosage substudy, single testosterone undecanoate dose (125, 250, 500, 750, or 1000 mg/kg body weight) was administered, and the optimal concentration was determined for 8weeks by measuring changes in testosterone, dihydrotestosterone, and 5-alpha reductase levels. And then, testosterone undecanoate was administered at the optimal dose at intervals of 1, 2, 3, or 4 weeks for 12weeks to induce benign prostatic hyperplasia. The injection dosage substudy showed dose-dependently higher and more stable levels of testosterone in groups administrated testosterone undecanoate than in groups administered testosterone propionate. In the injection cycle substudy, testosterone undecanoate-administered group stably maintained high levels of testosterone, dihydrotestosterone, and 5-alpha reductase compared with testosterone propionate-administered group for the same injection cycle; moreover, the prostate measurements, an important sign of benign prostatic hyperplasia, were significantly increased. Based on these two substudies, we determined the optimal conditions for inducing benign prostatic hyperplasia stably and more conveniently than that for testosterone propionate. This study suggests an extended application of testosterone undecanoate for inducing benign prostatic hyperplasia that can improve research reliability considering the half-life of testosterone as well as injection dosage and concentration.

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Section: Discussionmentioning

confidence: 99%

Comparative application of testosterone undecanoate and/or testosterone propionate in induction of benign prostatic hyperplasia in Wistar rats

Kong

2022

PLoS ONE

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“…Following a 1-week acclimatization period, a total of 41 rats were randomly assigned to one of five groups: sham ( n = 6), control ( n = 9), finasteride 1 mg/kg ( n = 8), TH extract 100 mg/kg ( n = 9), and TH extract 300 mg/kg ( n = 9). The sample size was determined based on previous research [ 25 , 26 ]. Rats were allocated to each group using a stratified random sampling method based on body weight to ensure equal average weights across groups.…”

Section: Methodsmentioning

confidence: 99%

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Lee,

Song

2024

Nutrients

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Benign prostatic hyperplasia (BPH) is the non-malignant enlargement of the prostate, associated with lower urinary tract symptoms (LUTSs). Taraxaci Herba (TH), commonly known as dandelion, has traditionally been utilized in East Asia to treat symptoms related to LUTSs. Based on this traditional use, our study aimed to explore the inhibitory effects of TH on BPH progression using a testosterone propionate-induced rat model. To induce BPH, male Sprague Dawley rats were castrated and injected subcutaneously with testosterone propionate (3 mg/kg/day) for 28 days. Concurrently, TH extract was administered orally at doses of 100 and 300 mg/kg/day throughout the four-week period of testosterone propionate injections. The TH extract significantly reduced both the absolute and relative weights of the prostate, along with histopathological changes in the gland. Moreover, it lowered serum levels of testosterone and dihydrotestosterone and reduced the expression of the androgen receptor in the prostate. Additionally, the TH extract modulated the protein expressions of Bax and Bcl-2, which are key regulators of apoptosis in prostate cells. Collectively, our findings suggest that TH inhibits BPH development partially by modulating androgen signaling and inducing apoptosis within the prostate.

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Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia

Krishnamoorthi,

Ganapathy A,

Hari Priya

et al. 2024

Journal of Ethnopharmacology

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Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate

Cited by 4 publications

References 21 publications

Comparative application of testosterone undecanoate and/or testosterone propionate in induction of benign prostatic hyperplasia in Wistar rats

Comparative application of testosterone undecanoate and/or testosterone propionate in induction of benign prostatic hyperplasia in Wistar rats

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia

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