Lipid Peroxidation and Resistance to Oxidation in Patients with Type 2 Diabetes Mellitus

Paşaoğlu, Hatîce; Sancak, Banu; Bukan, Neslihan

doi:10.1620/tjem.203.211

Cited by 101 publications

(88 citation statements)

References 41 publications

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“…The present results indicated the elevation of lipid peroxidation under diabetes. Other studies also reported that the formation of lipid peroxidation products in serum and tissues under diabetes is elevated (42,43), and leads to diabetic complications including retinopathy and neuropathy (44,45). The decrease in lipid peroxidation by the BuOH fraction from the broccoli flower implies a protective role against diabetic oxidative stress induced by STZ.…”

Section: Discussionmentioning

confidence: 94%

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Cho¹,

Lee²,

Yoo³

et al. 2006

J Nutr Sci Vitaminol

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SummaryThe antioxidative effect and protective potential against diabetes of the broccoli flower were investigated both in vitro and in a diabetic rat model. Among fractions of MeOH, CH 2 Cl 2 , BuOH, and H 2 O, the BuOH fraction exerted the strongest inhibitory activities on 1,1-diphenyl-2-picrylhydrazyl radical, radical-induced protein oxidation, and nitric oxide generation by sodium nitroprusside. The in vitro results suggest that the BuOH fraction from the broccoli flower has a protective potential against oxidative stress. The rat model with diabetes induced by streptozotocin was employed to evaluate the protective effect of the BuOH fraction in vivo. Diabetic rats showed reduced body weight gain and heavier kidney and liver weights than normal rats, while oral administration of the BuOH fraction at an oral dose of 100 or 200 mg/kg body weight/d for 20 d attenuated the physiological changes induced by diabetes. In addition, oral administration of the BuOH fraction to diabetic rats led to significant decreases in serum glucose and glycosylated protein, while it resulted in the increase of serum albumin, implying that the BuOH fraction improves the abnormal metabolism of glucose and protein that leads to oxidative stress. Moreover, it significantly reduced thiobarbituric acid-reactive substance levels in serum, hepatic and renal mitochondria. This suggests that the BuOH fraction would alleviate the oxidative stress associated with diabetes through the inhibition of lipid peroxidation. The present study demonstrates that the BuOH fraction has an antioxidative effect in vitro and it protects against oxidative stress induced by diabetes in an in vivo model.

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Section: Discussionmentioning

confidence: 94%

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Cho¹,

Lee²,

Yoo³

et al. 2006

J Nutr Sci Vitaminol

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“…ROS are also produced in the organism as a part of the primary immune defense. [22][23][24][25][26] Phagocytic cells such as neutrophils, monocytes, or macrophages defend against foreign organism by synthesizing large amount of superoxide anion radical and nitric oxide radical as a part of their killing mechanism. To counteract the prooxidant load a diversity of antioxidant defense systems are operative in biological systems including enzymatic and nonenzymatic antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Antioxidant Status in Male and Female Patients with Type 1 and Type 2 Diabetes Mellitus

Madhikarmi¹,

Singh

Khatun

2017

Med Phoenix

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Background: Free radicals are reactive oxygen species which cause lipid peroxidation precipitating many metabolic diseases including Diabetes Mellitus. However, these free radicals are quenched by substances known as antioxidants like vitamin C, vitamin E and several other compounds. Lipid peroxidation and antioxidant status were investigated in patients with Type 1 and Type 2 Diabetes mellitus-Pokhara, Nepal. Methods:The extent of lipid peroxidation was assessed by thiobarbituric acid reactive substances and the antioxidant parameter estimations were total antioxidant activity, Vitamin C and Vitamin E assessed in Type 1 and 2 diabetes mellitus patients along with matched healthy counterparts. results:The lipid peroxidation was increased in male Type 1 and 2 diabetic patients whereas female group showed decreased level as compared to its healthy counterparts. Similarly, the total antioxidant activity was found to be decreased in the diabetic group. The lipid peroxidation parameter and antioxidant status were statistically significant at p< 0.05. Conclusion:Oxidative stress and antioxidant status varied in male and female patients suffering from diabetes either Type 1 or Type 2. Apart from gender basis of evaluating oxidative stress, variables based on diet, habitat, socioeconomic status, education, etc. can also be considered.

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“…Serum protein thiols have been found to be decreased in patients that are suffering from complications of type 2 diabetes mellitus 37 . There have been reports on decreased plasma thiol levels in diabetic patients 38 . Substantial reduction in plasma-SH (P-SH) levels in diabetic hemodialysis (DHD) patients compared with the level in healthy participants and DM patients.…”

Section: Diabetes Mellıtus and Oxidative Stressmentioning

confidence: 99%

Oksidatif Stresin Bir Göstergesi Olarak Protein Thioller

Chianeh¹,

Prabhu²

2014

Arşiv Kaynak Tarama Dergisi

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ABSTRACT:Thiol is an organic compound that contain sulphhydryl group that have a critical role in preventing any involvement of oxidative stress in the cell. Among the protein defensive mechanism of the body, cysteine plays an important role in preventing an oxidative damage through its thiol functional group. These defensive functions are generally considered to be carried out by the low molecular weight thiol glutathione and by cysteine residues in the active sites of proteins such as thioredoxin and peroxiredoxin. In addition, there are thiols exposed on protein surfaces that are not directly involved with protein function, although they can interact with the intracellular environment.The process of protection of the cell against an oxidative damage occur by thiol and cystein residue that has a low molecular weight. These residue are present in the active sites of a protein like, peroxiredoxin and thioredoxin. Apart from intracellular antioxidant defense mechanism by protein thiol, there are presence of thiol in outer surface of protein that are not involved with the function of protein, even though they can interact with intracellular part of the cell. Key words: Free radicals, Thiols, antioxidants, glutathione, cysteine-SH, ÖZET Tiyol; hücrelerde herhangi bir oksitadif stres durumunun oluşumunu önlemede kritik bir role sahip sülfhidril grubunu içeren organik bir bileşiktir. Vücudun defansif protein mekanizmaları arasında yer alan sistein, içerdiği işlevsel tiyol grubu ile oksidatif hasarı önlemede önemli bir rol oynamaktadır. Bu defansif işlevler, genellikle tiyoredoksin ve peroredoksin gibi proteinlerin aktif bölgelerinde yer alan sistein depoları ve düşük moleküler ağırlığa sahip tiyol glutatyon aracılığıyla gerçekleştirilmelerine göre değerlendirilirler. İlaveten, tiyol direk olarak hücreler arası ortam ile iletişim halinde olabilmesine rağmen protein işlevinde direk olarak yer almayan protein yüzeylerinde yer almaktadır. Oksidatif

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Lipid Peroxidation and Resistance to Oxidation in Patients with Type 2 Diabetes Mellitus

Cited by 101 publications

References 41 publications

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Lipid Peroxidation and Antioxidant Status in Male and Female Patients with Type 1 and Type 2 Diabetes Mellitus

Oksidatif Stresin Bir Göstergesi Olarak Protein Thioller

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