Lipoprotein Lipase and Postheparin Esterase Activity After the Administration of Testosterone to Healthy Men and Women and to Patients with Cirrhosis of the Liver

Fabian, Eric; Kobilková, J; Stork, A; Sponarová, J

doi:10.1055/s-0028-1094082

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…The resemblance of uraemic men to women in this respect may be related to the diminished plasma concentrations of testosterone observed in males with chronic renal failure (Chen, Vidt, Zoru, Hallberg & Wieland, 1970;Holdsworth, Atkins & de Kretser, 1977). The observations that hepatic lipase is augmented by oxandrolone (Ehnholm, Huttenen, Kinnunen, Miettinen & Nikkila, 1975) and that total post-heparin lipolytic activity rises with testosterone administration (Fabian, Kobilkova, Stork & Sponarova, 1972) support this explanation. After renal transplantation, the rise in hepatic lipase to normal values in men and to activities significantly greater than normal in women may be a result of prednisone therapy, with perhaps an effect of normalization of circulating testosterone concentrations in male transplant recipients (Bailey, 1977).…”

Section: Discussionmentioning

confidence: 78%

Heparin-Released Plasma Lipases in Chronic Renal Failure and after Renal Transplantation

1979

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1. Post-heparin plasma from normal subjects, patients with chronic renal failure and recipients of renal allografts were subjected to affinity chromatography on heparin—agarose (Sepharose 4B) columns to separate two fractions representing hepatic lipase and lipoprotein lipase respectively. 2. The optimum conditions for assay of each fraction were determined for both normal and uraemic plasma. 3. Normal males had activities of hepatic lipase which were higher, and activities of lipoprotein lipase which were lower, than normal females. There was no consistent relationship to age for either enzyme. 4. Thirty patients with chronic renal failure untreated by dialysis had significantly elevated serum triacylglycerol concentrations, and significantly lowered lipoprotein lipase activities when compared with control groups with similar ages for each sex. However, only in uraemic males was hepatic lipase activity significantly reduced. 5. In a study of female patients with chronic renal failure, there were no significant differences in activities of hepatic lipase or lipoprotein lipase or concentrations of serum triacylglycerols between eight patients receiving dialysis treatment and eight untreated by dialysis. 6. Although serum triacylglycerol concentrations were raised in the group of 15 renal transplant recipients, lipase activities were not diminished. The only significant change was elevation of hepatic lipase activity in female graft recipients. 7. No relationship was found between the enzyme activities and fasting serum triacylglycerol concentrations in any group. However, there was a weak inverse correlation between serum creatinine and hepatic lipase in female patients from both renal failure and transplant groups. 8. Similar results were obtained when the enzymes were assayed with, as substrate, a laboratory-prepared emulsion of 14C-labelled triolein in water with soya-bean lecithin as emulsifier, or commercially prepared soya-bean oil in water, emulsified with egg-yolk lecithin and containing glycerol (Intralipid).

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Section: Discussionmentioning

confidence: 78%

Heparin-Released Plasma Lipases in Chronic Renal Failure and after Renal Transplantation

1979

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“…Cross‐sectional, observational studies in healthy men have shown a positive correlation between testosterone and HDL‐C circulating levels, 25–27 which has not been confirmed by others 28–30 . These findings are in contrast with well documented findings of HDL‐C decrease after exogenous androgen administration in both sexes 31–37 . Accordingly, androgen deprivation induced by surgical or chemical castration is associated with increased HDL‐C and apoprotein AI concentrations 38–41 .…”

Section: Discussionmentioning

confidence: 93%

Aging‐Related Decline of Gonadal Function in Healthy Men: Correlation with Body Composition and Lipoproteins

Denti

Pasolini

Sanfelici

et al. 2000

J American Geriatrics Society

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This study suggests that, in men, androgen decline caused by normal aging does not significantly affect some targets of testosterone action, such as body composition and lipid metabolism. Therefore, androgen supplementation in hypogonadal older men cannot be expected to influence nutritional status and body composition to the same extent that it does other main targets of testosterone action, such as sexual activity and muscle strength. However, we cannot exclude that selected subsets of older patients with low testosterone levels, especially if affected by catabolic disease, could benefit from the effects of androgen administration on nutritional status.

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“…HL has been demon strated in vitro to possess phospholipase activity with lecithin as well as cephalin as a substrate [5], whereby HL enhances transfer of lecithin and cephalin to their respective lyso forms. Steroids with androgenic properties, like oxandrolone [4,8], NET [9] and testosterone [6], increase post-heparin lipolytic activity. This increase has been shown to be due to a selective increase in HL when caused by steroids with androgenic properties, e.g" oxandrolone [4] and NORG [13], It is suggested that stimulation of HL and its phospholipase activity by NORG is the specific cause of the lysolecithinlecithin shift.…”

Section: Discussionmentioning

confidence: 99%

Lipid Metabolic Studies in Oophorectomized Women: Effects of Synthetic Progestogens on Individual Serum Phospholipids and Serum Lecithin Fatty Acid Composition

Silfverstolpe

Samsioe

Svanborg

et al. 1982

Gynecol Obstet Invest

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Norethisterone acetate (NET), levonorgestrel (NORG) and medroxyprogesterone acetate (MPA) were administered to oophorectomized women to evaluate the effects on individual serum phospholipids as well as serum lecithin and cholesterol ester fatty acid composition. Blood samples were drawn after a 3-week period without hormonal replacement therapy and after 3 weeks on each progestogen. NORG reduced cephaline and lecithin with a concomitant increase in lysolecithin. This shift in individual phospholipids has previously been induced by exogenous androgens. The 17C-alkylated synthetic progestogens NET and NORG but not the non-alkylated MPA caused a redistribution among the 1 -position fatty acids of serum lecithin with an increase in palmitic concomitant with a decrease in stearic acid. These findings indicate differences between 19-nortestosterone derivatives and 17-hydroxyprogesterone derivatives in effect on individual serum phospholipids and in influence on liver lecithin synthesis as judged from serum lecithin fatty acid composition.

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Lipoprotein Lipase and Postheparin Esterase Activity After the Administration of Testosterone to Healthy Men and Women and to Patients with Cirrhosis of the Liver

Cited by 7 publications

References 7 publications

Heparin-Released Plasma Lipases in Chronic Renal Failure and after Renal Transplantation

Heparin-Released Plasma Lipases in Chronic Renal Failure and after Renal Transplantation

Aging‐Related Decline of Gonadal Function in Healthy Men: Correlation with Body Composition and Lipoproteins

Lipid Metabolic Studies in Oophorectomized Women: Effects of Synthetic Progestogens on Individual Serum Phospholipids and Serum Lecithin Fatty Acid Composition

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