Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation

Hong, Yifan; Lee, Hea Young; Jung, Bong Jun; Jang, Soojin; Chung, Dae Kyun; Kim, Hangeun

doi:10.1016/j.molimm.2015.05.019

Cited by 49 publications

(47 citation statements)

References 51 publications

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“…Moreover, we observed that MMP-1 concentration was associated with dosimetric parameters. This is consistent with other reports that infrared or ultraviolet irradiation could dose-dependently induce MMP-1 expression [28–32]. These findings indicate that an association between MMP-1 expression and RILI is biologically plausible.…”

Section: Discussionsupporting

confidence: 93%

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

Liu

Tang

et al. 2016

Oncotarget

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Matrix metalloproteinase-1 (MMP-1) has been implicated in several inflammatory and fibrotic diseases. We hypothesized that genetic variations in the MMP1 promoter region are associated with risk of radiation-induced lung injury (RILI). A cohort of 251 lung cancer patients was genotyped for five single nucleotide polymorphisms in the MMP1 promoter region. We found that rs1144393 AG/GG was strongly correlated with an increased occurrence of grade ≥ 2 RILI (p = 0.002). Additionally, patients with the rs1144393 AG/GG genotypes exhibited higher MMP-1 expression than patients with the AA genotype in lung tissues (n = 28, p = 0.022) and plasma samples (n = 40, p = 0.018). Our results indicated that rs1144393 in the MMP1 promoter region can be a predictor of grade ≥ 2 RILI in lung cancer patients treated with thoracic radiation.

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Section: Discussionsupporting

confidence: 93%

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

Liu

Tang

et al. 2016

Oncotarget

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“…Thus, identification of MMP‐1 inhibitors is regarded as a promising strategy in terms of the development of antiphotoaging pharmaceuticals. Recent studies showed that MMP‐1 is produced in epidermal keratinocytes when the cells are exposed to UVB and dermal fibroblasts . In this study, we evaluated the preventive effects of PM on photoaging and on chronological aging involving MMP‐1.…”

Section: Discussionmentioning

confidence: 99%

Plantamajoside Inhibits UVB and Advanced Glycation End Products‐Induced MMP‐1 Expression by Suppressing the MAPK and NF‐κB Pathways in HaCaT Cells

Han

Nam

Lee

2016

Photochem & Photobiology

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Photoaging and glycation stress are major causes of skin deterioration. Oxidative stress caused by ultraviolet B (UVB) irradiation can upregulate matrix metalloprotease 1 (MMP-1), a major enzyme responsible for collagen damage in the skin. Advanced glycation end products (AGEs) accumulate via gradual formation from skin proteins, especially from long-lived proteins such as dermal elastin and collagen. Plantamajoside (PM), isolated from Plantago asiatica, has various biological effects including anti-inflammatory and antioxidant effects. In this study, we assessed the protective effects of PM on a human keratinocyte cell line (HaCaT) and primary human dermal fibroblasts (HDF) against stress caused by glyceraldehyde-induced AGEs (glycer-AGEs) with UVB irradiation. We found that PM attenuated UVB- and-glycer-AGEs-induced MMP-1 expression in HaCaT and HDF cells and proinflammatory cytokines expression by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) activated by reactive oxygen species. Specific inhibitors of NF-κB and MAPKs attenuated the induced expression of MMP-1. PM also inhibited the phosphorylation of IκBα, and reduced nuclear translocation of NF-κB in these cells. Furthermore, PM attenuated the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation. Therefore, our findings strongly suggest that PM is a promising inhibitor of skin photoaging.

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“…사람 피부에는 19종의 MMP가 존재하는데 그 중 MMP-1, MMP-3, MMP-9만 UV에 의하여 증가한다 (Quan et al, 2009 (Quan et al, 2009). 한편, 콜라겐 1형은 섬유아세포에서 procollagen 형 태로 합성되어 세포외기질로 분비되기 때문에 (Hong et al, 2015;Hwang et al, 2014) (Han et al, 2015). 또한, Heo et al (2001) (Li & Wang, 2011;Liang et al, 1999 Figure 4B).…”

Section: 피부노화에서 공통적으로 나타나는 주름은 진피층의 세포unclassified

Prevention Effect of Prunus persica Flos Extract from Reactive Oxygen Species Generation and Matrix Metalloproteinases Production Induced by UVB Irradiation in Human Skin Cells

Kwak¹,

Yang²

2016

Asian J Beauty Cosmetol

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Purpose: Prunus persica Flos (PPF, peach flowers) extracts were reported to have anti-oxidant and anti-inflammatory activities. In this study, we investigated whether PPF extracts prevent the human skin cells from oxidative stress and matrix metalloproteinases (MMPs) induced by UVB irradiation which ultimately leads to photoaging, or not. Methods: Ethanol extract (Et) of PPF and its dichloromethane (DM), ethylacetate (EA), and n-butanol (Bt) fractions were pretreated in UVB-irradiated (75 mJ/cm 2) human keratinocytes (HaCaT) or human dermal fibroblasts (HDF). Cellular reactive oxygen species (ROS) generation was measured using DCF-DA assay, and mRNA expression and production of MMPs were measured by real-time PCR and Western blotting, respectively. Results: The treatment of Et, DM, EA, and Bt significantly inhibited UVB-induced ROS generation and MMP-1 production in HaCaT cells. The treatments of EA and Bt significantly decreased not only the mRNA expression of MMP-1, MMP-3, and MMP-9 but also the protein production of MMP-1 and MMP-3 in HDF cells, while they increased the expression of type-1 procollagen in mRNA and protein levels. Et and DM significantly inhibited only MMP-1 and MMP-3 production without an preventive effect on type-1 procollagen production in UVB-irradiated HDF cells. Conclusion: The treatments with EA and Bt fractions from PPF extract protected human skin cells from UVB-induced oxidative stress and collagen loss. These findings suggest that EA and Bt fractions from PPF extract have the potential of natural resource for a skin anti-photoaging product in the food and cosmetic industry.

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Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation

Cited by 49 publications

References 51 publications

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy

Plantamajoside Inhibits UVB and Advanced Glycation End Products‐Induced MMP‐1 Expression by Suppressing the MAPK and NF‐κB Pathways in HaCaT Cells

Prevention Effect of Prunus persica Flos Extract from Reactive Oxygen Species Generation and Matrix Metalloproteinases Production Induced by UVB Irradiation in Human Skin Cells

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