Liver Enzymes In Diabetic And Non Diabetic Subjects With Clinically Diagnosed Hepatitis

Abstract

The occurrence of liver disease and raised liver enzymes is common in diabetic patients and the increasing level of enzymes indicates the severity of hepatic injury. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to diabetes.This study investigated a total of 1400 diabetic patients and 100 non diabetic individuals to compare the level of liver enzymes between diabetic and non-diabetic subjects. The comparisons were made among subjects who were referred to the department of Gastro-hepato-pancreatic diseases (GHPD) of BIRDEM with the clinical diagnosis of chronic hepatitis and other gastro-intestinal disorders. The investigations included alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin levels. The subjects were categorized with and without hepatitis based on these investigations.

Impact of Co-administration of Red Palm Oil (Elaeis guineensis Arecaceae) and Rooibos (Aspalathus linearis Fabaceae) on Glycaemic Parameters, Liver Function and Key Glycolytic Enzymes in Diabetic Rats

“…The liver plays a vital role in carbohydrate metabolism regulation and liver function tests are frequently used in clinical practice to screen for liver disease, monitor the progression of known disease, and monitor the effects of potentially hepatotoxic drugs [5]. Serum aminotransferases such as ALT indicates the concentration of intracellular hepatic enzymes that have seeped out into circulation which serves as a marker of hepatocyte injury [18].…”

“…Hyperglycaemia (excessive glucose level) is a link between diabetes and diabetic complications [2] and also plays a vital role in increased protein glycosylation [3,4]. Elevated liver enzymes in serum are widespread in diabetic patients and this reflects the severity of hepatic injury [5].…”