Lnc-M2 controls M2 macrophage differentiation via the PKA/CREB pathway

Chen, Yuxiang; Li, Hanzhao; Ding, Tengteng; Li, Jinbang; Zhang, Yuanbin; Wang, Jianguo; Yang, Xu; Chong, Tuotuo; Long, Yun; Li, Xin; Gao, Fei; Lyu, Xiaoming

doi:10.1016/j.molimm.2020.06.006

Cited by 19 publications

(12 citation statements)

References 51 publications

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“…Several ncRNAs and proteins have long been believed to play pivotal roles in determining the direction of macrophage polarization [ 83 ]. Lnc-M2 binds to PKA protein to activate its downstream CREB, thereby facilitating the process of M2 macrophage polarization [ 84 ]. Previously, a study indicated that M1 macrophages had higher levels of lncRNA-CCAT1 than that in M0 and M2 macrophages.…”

Section: Macrophage Polarizationmentioning

confidence: 99%

The Roles of Tumor-Associated Macrophages in Prostate Cancer

Han

Deng

et al. 2022

Journal of Oncology

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The morbidity of prostate cancer (PCa) is rising year by year, and it has become the primary cause of tumor-related mortality in males. It is widely accepted that macrophages account for 50% of the tumor mass in solid tumors and have emerged as a crucial participator in multiple stages of PCa, with the huge potential for further treatment. Oftentimes, tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) behave like M2-like phenotypes that modulate malignant hallmarks of tumor lesions, ranging from tumorigenesis to metastasis. Several clinical studies indicated that mean TAM density was higher in human PCa cores versus benign prostatic hyperplasia (BPH), and increased biopsy TAM density potentially predicts worse clinicopathological characteristics as well. Therefore, TAM represents a promising target for therapeutic intervention either alone or in combination with other strategies to halt the “vicious cycle,” thus improving oncological outcomes. Herein, we mainly focus on the fundamental aspects of TAMs in prostate adenocarcinoma, while reviewing the mechanisms responsible for macrophage recruitment and polarization, which has clinical translational implications for the exploitation of potentially effective therapies against TAMs.

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Section: Macrophage Polarizationmentioning

confidence: 99%

The Roles of Tumor-Associated Macrophages in Prostate Cancer

Han

Deng

et al. 2022

Journal of Oncology

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“…It has been reported that lncRNAs are also involved in the regulation of macrophage polarization. Chen reported that lnc-M2 controlled M2 macrophage differentiation via the PKA/CREB pathway [ 16 ]. LncRNA GAS5 was found to promote M1 macrophage polarization via the miR-455-5p/SOCS3 pathway in childhood pneumonia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM

Lai

Zhang

et al. 2021

Bioengineered

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Colorectal cancer (CRC) threatens the health of patients with high mortality, which lacks sensitive biomarkers for diagnosis to improve total survival. The lncRNA NBR2 is reported to be downregulated in CRC and suppresses the proliferation of CRC cells. However, the underlying mechanisms remain unclear. The present study aimed to explore the regulatory function of the lncRNA NBR2 on tumor-associated macrophage (TAM) polarization and its consequent anti-tumor effect. Two CRC cell lines were used in this study. We found that the lncRNA NBR2, TNF-α, and HLA-DR were downregulated, and Arg-1, CD163, CD206, and IL-4 were upregulated in CRC tumors. M1 polarization was activated and M2 polarization was suppressed in NBR2-overexpressed macrophages, accompanied by increased production of inflammatory factors, decreased proliferation, and inhibited migration ability in the co-culture system of HCT-116 cells (SW480 cells) and NBR2overexpressed macrophages. The promoted proliferation and migration were observed in the coculture system of HCT-116 cells (SW480 cells) and NBR2-knockdown macrophages. The tumor growth of both HCT-116 cells and SW480 cells in the xenograft model was suppressed by coplanting NBR2-overexpressed macrophages and was facilitated by the co-planting of NBR2knockdown macrophages. The release of inflammatory factors was induced, M1 polarization was facilitated, and M2 polarization was suppressed in tumor tissues in the NBR2-overexpressed group, which were all reversed in the NBR2-knockdown group. Therefore, the lncRNA NBR2 suppressed the progression of colorectal cancer in vitro and in vivo by regulating TAM polarization.

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“…LncRNAs mediate the regulation of TME by TAMs to affect tumor progression ( 96 , 97 ). One study showed CRC cell-derived exosomes transport RPPH1 to macrophages, mediate the M2 polarization of macrophages and affect TME, thereby promoting the metastasis of CRC cells ( 98 ).…”

Section: Roles and Mechanism Of Ncrnas In Tmementioning

confidence: 99%

Non-Coding RNAs Implicated in the Tumor Microenvironment of Colorectal Cancer: Roles, Mechanisms and Clinical Study

2022

Front. Oncol.

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Colorectal cancer (CRC) is one of the most common malignant tumors. The morbidity and mortality rates have been increasing all over the world. It is critical to elucidate the mechanism of CRC occurrence and development. However, tumor microenvironment (TME) includes immune cells, fibroblasts, endothelial cells, cytokines, chemokines and other components that affect the progression of CRC and patients’ prognosis. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) without protein-coding ability have been shown to engage in tumor microenvironment-mediated angiogenesis and metastasis. Therefore, clarifying the mechanism of ncRNAs regulating the microenvironment is very important to develop the therapeutic target of CRC and improve the survival time of patients. This review focuses on the role and mechanism of ncRNAs in the CRC microenvironment and puts forward possible clinical treatment strategies.

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Lnc-M2 controls M2 macrophage differentiation via the PKA/CREB pathway

Cited by 19 publications

References 51 publications

The Roles of Tumor-Associated Macrophages in Prostate Cancer

The Roles of Tumor-Associated Macrophages in Prostate Cancer

Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM

Non-Coding RNAs Implicated in the Tumor Microenvironment of Colorectal Cancer: Roles, Mechanisms and Clinical Study

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