Local hemostatics (A review)

Belozerskaya, G.G.; Makarov, V. A.; Zhidkov, E. A.; Malykhina, L. S.; Sergeeva, Olga A.; Ter-Arutyunyants, A. A.; Makarova, L. V.

doi:10.1007/s11094-006-0126-3

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…Although they are all based on the same polysaccharide, some differences between modified types of cellulose that could be important in clinical use do occur. Highly oxidized cellulose can be used as a nontoxic hemostatic agent possessing antimicrobial and wound-healing properties [2]. Other modified celluloses are also utilized in the biomedical field for a variety of purposes, in part because they easily degrade to nontoxic materials.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Kollár

Závalová

Hošek

et al. 2011

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Kollár

Závalová

Hošek

et al. 2011

International Immunopharmacology

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“…As the continuation of our research program directed at antibacterial composites [41][42][43][44], we present here the paper on PLA-Cu composites consisting of a hemostatic matrix [39,[45][46][47][48][49] and hemostatic metal [50][51][52][53][54][55][56].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Approach to Poly(Lactide)–Copper Composite—Impact on Blood Coagulation Processes

Mrozińska,

Kudzin,

Ponczek

et al. 2024

Materials

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The paper presents the investigation of the biological properties of Poly(Lactide)—Copper composite material obtained by sputter deposition of copper onto Poly(lactide) melt-blown nonwoven fabrics. The functionalized composite material was subjected to microbial activity tests against colonies of Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, Chaetomium globosum and Candida albicans fungal mold species and biochemical–hematological tests including the evaluation of the Activated Partial Thromboplastin Time, Prothrombin Time, Thrombin Time and electron microscopy fibrin network imaging. The substantial antimicrobial and antifungal activities of the Poly(Lactide)–Copper composite suggests potential applications as an antibacterial/antifungal material. The unmodified Poly(Lactide) fabric showed accelerated human blood plasma clotting in the intrinsic pathway, while copper plating abolished this effect. Unmodified PLA itself could be used for the preparation of wound dressing materials, accelerating coagulation in the case of hemorrhages, and its modifications with the use of various metals might be applied as new customized materials where blood coagulation process could be well controlled, yielding additional anti-pathogen effects.

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“…The current study is a continuation of our research program aimed at developing antibacterial polymer-metal composites [49][50][51][52][53][54] and is focused on the PLA-Zn composites made from a matrix with hemostatic properties [35][36][37][38][39][40] (but without an inherent antibacterial effect [55]) and with an antipathogenic (antibacterial [56][57][58][59][60][61][62][63][64][65]; antiviral [66][67][68][69][70][71][72][73][74][75][76][77]; and antifungal [78][79][80][81][82][83][84][85][86][87]), hemostatic [88][89][90]…”

Section: Introductionmentioning

confidence: 99%

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Mrozińska,

Ponczek,

Kaczmarek

et al. 2024

Coatings

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This article presents the biochemical properties of poly(lactide)-zinc (PLA-Zn) composites obtained by DC magnetron sputtering of zinc onto melt-blown nonwoven fabrics. The biochemical properties were determined by the evaluation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The antimicrobial activity of the PLA-Zn samples was additionally tested against representative Gram-positive and Gram-negative bacteria strains. A structural study of the PLA-Zn has been carried out using specific surface area and total pore volume (BET) analysis, as well as atomic absorption spectrometry with flame excitation (FAAS). PLA-Zn composites exhibited an antibacterial effect against the analyzed strains and produced inhibition zones against E. coli and S. aureus. Biochemical investigations revealed that the untreated PLA fibers caused the acceleration of the clotting of human blood plasma in the intrinsic pathway. However, the PLA-Zn composites demonstrated significantly different properties in this regard, the aPTT was prolonged while the PT was not altered.

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Local hemostatics (A review)

Cited by 9 publications

References 49 publications

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Biochemical Approach to Poly(Lactide)–Copper Composite—Impact on Blood Coagulation Processes

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

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