Long-term normalization of diabetes mellitus after xenotransplantation of fetal pancreatic islet cells into the blood stream without immunosuppresive therapy

Long-term preservation of vitality of xenogenic thyrocytes in the recipient after their transplantation into the blood stream

“…The concept suggested is in accordance with the findings obtained by other researchers who proved it possible to considerably increase the terms of the islets functioning in the portal vein lumen compared to their intraperitoneal (omental pouch) and intrarenal (renal subcapsular space) introduction [2]. According to Prochorov AV, Tretjak SI et al, an unaffected intima is a powerful barrier that provides a nonstandard immune response to the grafted tissue, which eventually makes it possible for the foreign tissue to survive in the recipient's organism [1]. Ohzato and colleagues pointed out that the lack of the graft's cellular infiltration, humoral rejection and complications in grafting encapsulated xenogenic islets in the arterio-venous fistula (common iliac arteries and veins) [3].…”

“…Our previous research and studies carried out by other researchers on grafting pancreatic islets showed that it was possible to preserve the vitality of xenogenic tissue for a long time and maintain its functioning in the blood stream without using immunosupression, i.e. the blood stream is one of the immunologically privileged areas [1][2][3]. Therefore, we set as a goal of the present research to study the possibility of the long-term preservation and functioning of thyrocytes xenogenic culture in the recipient without using medicinal immunoprotection.…”

Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices

“…Numerous vascular perfusion devices were developed to overcome transport challenges. Common iliac artery and the common iliac vein are the popular sites to use (Maki et al, 1991a,b, 1993, 1996b) in addition to aortic lumen (Prochorov et al, 2004, 2005) in canine models. vascular perfusion devices were also grafted into the deep femoral artery or the forearm cubital vein after performing AV anastomosis in patients (Prochorov et al, 2008).…”

Xenotransplantation Literature Update January–February, 2005

“…Prochorov et al [13] transplanted rabbit fetal pancreatic islets (that were previously macroencapsulated into a microporous polyamide) directly into the arterial blood stream of dogs, into the aorta at the level of the two renal arteries, without immunosuppressive therapy. They demonstrated long‐term insulin secretion, preservation of islet cell viability, and absence of graft rejection.…”

“…They demonstrated long‐term insulin secretion, preservation of islet cell viability, and absence of graft rejection. They speculate that immune isolation of islet cells by macroencapsulation, and implantation directly into the blood stream, improve their long‐term viability [13].…”