Long-term outcomes of patients with Streptococcus suis infection in Viet Nam: A case-control study

Huong, Vu Thi Lan; Hoang, Long Bao; Kính, Nguyễn Văn; Ngan, Ta Thi Dieu; Dung, Vu Tien Viet; Nadjm, Behzad; Doorn, H. Rogier van; Hoa, Ngo Thi; Horby, Peter; Wertheim, Heiman

doi:10.1016/j.jinf.2017.09.019

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…De hecho, este agente es el más frecuente en casos de meningitis bacteriana aguda en algunos países del sudeste asiático 3 . Es de interés también destacar la hipoglucorraquia extrema y la alta tasa de secuelas auditivas asociadas a esta especie, y cuya frecuencia se reduce con el uso de corticoesteroides, aunque en este caso no demostró tener impacto 3,4 .…”

Section: Discussionunclassified

Meningitis e hipoacusia por manipulación de carne porcina

Moraga

Fíca

Navarrete

et al. 2018

Rev. chil. infectol.

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Meningitis and hypoacusia due to swine meat handling Zoonotic meningitis by Streptococcus suis has been described occasionally in Chile and linked to pig farmers in the south of the country. We report a female case that developed acute bacterial meningitis by this agent, two days after handling a piece of raw swine meat. She did not participate on swine breeding nor visited farms. Diagnosis was obtained by CSF culture. A severe hearing loss and not recovered despite corticosteroids use and antimicrobial treatment, without others complications. Meningitis by S. suis is emerging as a new pathogen and linked to swine in different forms. Hypoacusis happens frequently with this agent.

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Section: Discussionunclassified

Meningitis e hipoacusia por manipulación de carne porcina

Moraga

Fíca

Navarrete

et al. 2018

Rev. chil. infectol.

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“…Data on mortality and disability were obtained through a systematic literature review 2 and a prospective follow-up study of patients with laboratory-confirmed S. suis infection admitted to the National Hospital for Tropical Diseases (NHTD) in Hanoi, Viet Nam between November 2014 and October 2015. 10…”

Section: Methodsmentioning

confidence: 99%

“…2 However, we also checked how the burden estimates vary if applying a smaller CFR of 4%, the pooled estimate for studies with meningitis patients. In the follow-up study, all cases with severe hearing loss showed vestibular dysfunction, 10 therefore we did not consider the impact of severe hearing loss without vestibular dysfunction in S. suis survivors. Hearing loss was defined based on audiometry, which measured the average of hearing thresholds over four frequencies (0.5, 1, 2 and 4 kHz) in the better ear.…”

Section: Methodsmentioning

confidence: 99%

“…Hearing loss was defined based on audiometry, which measured the average of hearing thresholds over four frequencies (0.5, 1, 2 and 4 kHz) in the better ear. 10 We categorized hearing as normal (if the average was <20 dB), mild (20–34 dB), moderate (35–49 dB), severe loss (50–79 dB) and profound to complete loss (≥80–94 dB).…”

Section: Methodsmentioning

confidence: 99%

“…10 We categorized hearing as normal (if the average was <20 dB), mild (20–34 dB), moderate (35–49 dB), severe loss (50–79 dB) and profound to complete loss (≥80–94 dB).…”

Section: Methodsmentioning

confidence: 99%

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Burden of disease and economic impact of human Streptococcus suis infection in Viet Nam

Huong

Turner

Kính

et al. 2019

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Streptococcus suis is a zoonotic disease mainly affecting men of working age and can result in death or long-term sequelae, including severe hearing loss and vestibular dysfunction. We aimed to quantify the burden of disease and economic impact of this infection in Viet Nam. Methods The annual disease incidence for the period 2011–2014 was estimated based on surveillance data using a multiple imputation approach. We calculated disease burden in disability-adjusted life years (DALYs) and economic costs using an incidence-based approach from a patient’s perspective and including direct and indirect impacts of S. suis infection and its long-term sequelae. Results The estimated annual incidence rate was 0.318, 0.324, 0.255 and 0.249 cases per 100 000 population in 2011, 2012, 2013 and 2014, respectively. The corresponding DALYs lost were 1832, 1866, 1467 and 1437. The mean direct cost per episode was US$1635 (95% confidence interval 1352–1923). The annual direct cost was US$370 000–500 000 and the indirect cost was US$2.27–2.88 million in this time period. Conclusions This study showed a large disease burden and high economic impact of S. suis infection and provides important data for disease monitoring and control.

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A Bacterial mRNA‐Lysis‐Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery

Li,

Sun,

Zhang

et al. 2023

Advanced Science

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Engineered vector‐based in vivo protein delivery platforms have made significant progress for both prophylactic and therapeutic applications. However, the lack of effective release strategies results in foreign cargo being trapped within the vector, restricting the provision of significant performance benefits and enhanced therapeutic results compared to traditional vaccines. Herein, the development of a Salmonella mRNA interferase regulation vector (SIRV) system is reported to overcome this challenge. The genetic circuits are engineered that (1) induce self‐lysis to release foreign antigens into target cells and (2) activate the cytosolic surveillance cGAS‐STING axis by releasing DNA into the cytoplasm. Delayed synthesis of the MazF interferase regulates differential mRNA cleavage, resulting in a 36‐fold increase in the delivery of foreign antigens and modest activation of the inflammasome, which collectively contribute to the marked maturation of antigen‐presenting cells (APCs). Bacteria delivering the protective antigen SaoA exhibits excellent immunogenicity and safety in mouse and pig models, significantly improving the survival rate of animals challenged with multiple serotypes of Streptococcus suis. Thus, the SIRV system enables the effective integration of various modular components and antigen cargos, allowing for the generation of an extensive range of intracellular protein delivery systems using multiple bacterial species in a highly efficient manner.

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Long-term outcomes of patients with Streptococcus suis infection in Viet Nam: A case-control study

Cited by 11 publications

References 25 publications

Meningitis e hipoacusia por manipulación de carne porcina

Meningitis e hipoacusia por manipulación de carne porcina

Burden of disease and economic impact of human Streptococcus suis infection in Viet Nam

A Bacterial mRNA‐Lysis‐Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery

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