Low birth weight at term impairs cord serum lipoprotein compositions and concentrations

Merzouk, Hafida; Bouchenak, Malika; El-Korso, N.; Belleville, J.; Prost, Josiane

doi:10.1007/s004310050820

Cited by 36 publications

(24 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,10,11 In agreement with our findings, Lane et al 5 found that preterm infants developing respiratory distress post-natally had significantly lower cord serum lipid levels than those of normal term infants or preterm infants free of respiratory distress. Significantly lower cord serum lipid levels are evidence of reduced essential fatty acids and long-chain polyunsaturated fatty acid supply, which could inhibit fetal growth in utero, delaying maturation of fetal lungs.…”

Section: Discussionsupporting

confidence: 91%

Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

2007

View full text Add to dashboard Cite

Background: Lipid metabolism has an important role in fetal development during the late stage of gestation, including growth and fat accretion in utero, increasing amniotic fluid lecithin levels with maturation of pulmonary function and changes in the levels of minor phospholipids in amniotic fluid.Objective: The aim of this study was to compare the maternal and cord lipid profiles of preterm infants with respiratory distress syndrome (RDS) and a control group without RDS. Method:The study groups consisted of 166 preterm infants with gestational ages ranging from 25 to 36 weeks, and birth weights ranging from 748 to 2495 g. Of these infants, 57 developed RDS and 109 infants served as controls. The infants were divided into four gestational age groups (34 to 36, 31 to 33, 28 to 30 and 25 to 27 weeks). Stepwise linear regression analyses were performed to determine independent contribution of each lipid parameter of the infants to their characteristics and mothers' variables.Result: Total cholesterol, high-density and low-density lipoproteins (LDL) cholesterols levels were lower in infants with RDS and in their mothers than in controls, and maternal lipid profile was related to those of their infants (P<0.05). Pregravid body mass index (BMI) was related to triglyceride levels of the infants, and weight gain during pregnancy was related to LDL cholesterol levels of the infants (P<0.05).Conclusion: RDS is accompanied with lipid alteration in infants and their mothers. Pregravid BMI and weight gain during pregnancy might have a prognostic significance in the prediction of respiratory distress in early neonatal period.

show abstract

Section: Discussionsupporting

confidence: 91%

Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

2007

View full text Add to dashboard Cite

show abstract

“…6,7,8 In agreement with our findings, Lane et al 5 found that preterm infants developing respiratory distress post-nataly had significantly lower cord serum lipid levels than those of normal term infants or preterm infants free of respiratory distress. Significantly lower cord serum lipid levels are evidence of reduced essential fatty acids and long-chain polyunsaturated fatty acid supply, which could inhibit fetal growth in utero delaying maturation of fetal lungs.…”

Section: Discussionsupporting

confidence: 82%

“…(4)(5)(6) and severe. (7)(8)(9)(10) Cord blood samples were obtained from umbilical vein immediately after delivery and allowed to clot at room temperature for 20 min. Serum was separated by centrifugation (20min, 2500 rpm) and kept at analysis was done.…”

Section: Methodsmentioning

confidence: 99%

Lipid Profile in RDS Group and Non-RDS Group: A Comparison Study

Sanjay¹,

Haseen²,

Somala³

et al. 2015

jemds

View full text Add to dashboard Cite

Lipid metabolism has an important role in fetal development during the late stage of gestation including growth and fat accretion in utero, increasing amniotic fluid lecithin levels with maturation of pulmonary function and changes in the levels of minor phospholipids in amniotic fluid. OBJECTIVEThe aim of this study was to compare cord lipid profiles of preterm infants with Respiratory Distress Syndrome (RDS) and a control group without RDS. METHODThe study groups consisted of 56 preterm infants with gestational ages ranging from 28 to 36 weeks and birth weights ranging from 0.8 to 2.26kg. Of these infants, 29 developed RDS and 27 infants served as controls. Cord blood lipid profile was done in both the groups and compared. RESULTTotal cholesterol, high-density and Low-Density Lipoproteins (LDL) cholesterols levels were lower in infants with RDS than in controls (P<0.05). CONCLUSIONRDS is accompanied with lipid alteration in infants.

show abstract

“…But in the present study there was a lack of correlation between maternal post-delivery BMI and the neonates' lipid profile. Various factors during pregnancy are said to have strong influence on foetal lipid metabolism [12,13] and hence the scope of extensive research in the current field remains plausible.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

2012

View full text Add to dashboard Cite

Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score [7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates' lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

show abstract

Low birth weight at term impairs cord serum lipoprotein compositions and concentrations

Cited by 36 publications

References 36 publications

Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

Lipid Profile in RDS Group and Non-RDS Group: A Comparison Study

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

Contact Info

Product

Resources

About