Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

Güneş, Tamer; Köklü, Esad; Öztürk, Mehmet

doi:10.1038/sj.jp.7211775

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…4;6;32-35 While a number of studies have observed a positive association between preterm birth and elevated TNF-α 2;3;28 or preterm birth and indicators of hyperlipidemia, 4;6;35 other studies have observed no such association. 29-31;33;34 In the current study, we observed evidence for such inconsistency as well. For example, whereas in California samples an elevated TNF-α and an elevated TGs:HDL ratio was associated with an increased risk for early preterm birth before consideration of cooccurrence, no such pattern was observed in Iowa samples.…”

Section: Commentsupporting

confidence: 67%

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Jelliffe‐Pawlowski¹,

Ryckman

Bedell

et al. 2014

American Journal of Obstetrics and Gynecology

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Objective To determine whether pregnancies resulting in early preterm birth (< 30 weeks) were more likely than term pregnancies to have elevated mid-trimester tumor necrosis factor alpha (TNF-α) levels co-occurring with lipid patterns suggestive of hyperlipidemia. Study Design Patterns were examined using stored non-fasted serum samples from 108 California and 734 Iowa singleton pregnancies collected as part of statewide prenatal screening. The frequency of elevated mid-pregnancy serum TNF-α levels and lipid patterns suggestive of hyperlipidemia (e.g. elevated total cholesterol (TC), low-density-lipoproteins (LDLs), or triglycerides (TGs), decreased high-density lipoproteins (HDLs)) (considered independently and by co-occurrence) were compared in pregnancies resulting in early preterm birth to those resulting in term birth using logistic regression models. Results While no differences between preterm and term pregnancies were evident when TNF-α or target lipid abnormalities occurred in isolation, early preterm pregnancies were two to four times more likely than term pregnancies to have elevated TNF-α levels co-occurring with indicators of hyperlipidemia (37.5% versus 13.9% in the California sample (adjusted OR 4.0, 95% CI 1.1 – 16.3) and 26.3% versus 14.9% in the Iowa sample (adjusted OR 2.7, 95% CI 1.1 – 6.3)). Observed differences were not explicable to any maternal or infant characteristics. Conclusion Pregnancies resulting in early preterm birth were more likely than term pregnancies to have elevated mid-pregnancy TNF-α levels co-occurring with lipid patterns suggestive of hyperlipidemia. Patterns offer clues for further study of the signaling of early parturition in preterm birth.

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Section: Commentsupporting

confidence: 67%

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Jelliffe‐Pawlowski¹,

Ryckman

Bedell

et al. 2014

American Journal of Obstetrics and Gynecology

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“…These changes may be attributed to the maturity of pregnancy and also the nutritional status of the fetus. Earlier study [11] has found a close relationship between pregravid BMI and TG levels of neonates. But in the present study there was a lack of correlation between maternal post-delivery BMI and the neonates' lipid profile.…”

Section: Discussionmentioning

confidence: 68%

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

2012

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Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score [7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates' lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

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Section: Introductionmentioning

confidence: 99%

“…Cord lipid concentrations have been analyzed in human neonates with respiratory distress syndrome (RDS) [6,7]. Gunes et al [7] reported that total cholesterol (TC), HDL, and LDL cholesterol levels were lower in infants with RDS and in their mothers. Lane et al [6], on the other hand, demonstrated elevated TC and TG levels in larger RDS infants with birth weight of 2000 to 2499 g and impaired lipid transport across the placenta in smaller RDS infants.…”

Section: Introductionmentioning

confidence: 99%

Very low-density lipoprotein in the cord blood of preterm neonates

Yonezawa¹,

Okada²,

Kitamura³

et al. 2009

Metabolism

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Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome

Cited by 12 publications

References 16 publications

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

Very low-density lipoprotein in the cord blood of preterm neonates

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