Low Fetal Loss Rates After Ultrasound-Proved Viability in Early Pregnancy

Abstract

Once pregnancy is recognized clinically, it is accepted that 12% to 15% undergo spontaneous abortion. However, the actual time of fetal demise has not yet been determined. To address this question, the outcomes of pregnancies identified before 21 days of conception by serum beta-human chorionic gonadotropin assays were studied. All subjects underwent ultrasound examinations at eight and 12 weeks' gestation. Among 220 women who had a viable pregnancy at eight weeks, only seven (3.2%) experienced a fetal loss thereafter. The results of this study suggest that most clinically recognized spontaneous abortions manifested after eight weeks actually represent pregnancies in which fetal demise occurred before eight weeks. These findings have important implications with respect to the safety of chorionic villi sampling and to the identification of exogenous agents that cause fetal wastage.

Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial

“…After experiencing a loss, couples desire information about future risk of subsequent pregnancy loss. Whereas current practices of ultrasonography are extensively utilized to predict real-time pregnancy viability (4), less is known about preconception biomarkers to predict the risk of loss in a future pregnancy.…”

Does the fibrinogen/albumin ratio predict the prognosis of pregnancies with abortus imminens?

“…It frequently occurs during the first 12 weeks of pregnancy. Abortus imminens affects approximately 20-50% of all pregnancies 1 and it may cause abdominal cramps or pelvic pain. Recent studies clearly demonstrated that there is an increased risk of adverse pregnancy outcomes such as preterm delivery, low birth weight, and perinatal death in AI pregnancies.…”