Abstract-Current analog harmonic rejection mixers typically provide 30-40 dB of harmonic rejection, which is often not sufficient. We present a mixed analog-digital approach to harmonic rejection mixing that uses a digital interference canceler to reject the strongest interferer. Simulations indicate that, given a practical RF scenario, the digital canceler is able to improve the signal-to-interference ratio by 30-45 dB.Index Terms-Adaptive filter, CMOS, cognitive radio, gain and phase mismatch, harmonic rejection mixing, I/Q imbalance, interference canceling, LMS, software-defined radio, switching mixers.