Low-protein, high-carbohydrate diet increases glucose uptake and fatty acid synthesis in brown adipose tissue of rats

França, Suélem Aparecida de; Santos, Maísa Pavani dos; Costa, Roger Vinícius Nunes Queiroz da; Froelich, Mendalli; Buzelle, Samyra Lopes; Chaves, Valéria Ernestânia; Giordani, Morenna Alana; Pereira, Mayara Peron; Colodel, Edson M.; Andrade, Claudia Marlise Balbinotti; Kawashita, Nair Honda

doi:10.1016/j.nut.2013.10.004

Cited by 16 publications

(11 citation statements)

References 46 publications

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“…Our use of a 10% protein diet could be the reason the low-protein diet did not induce a decrease in body weight. The food intake of the mice fed the low-protein diet was significantly higher than that of the control mice, which is in accordance with the results of previous studies [1, 2, 25]. On the other hand, the protein intake of the low-protein mice in our experiment was significantly lower than that of the control mice, which indicates that protein restriction was clearly achieved in this study.…”

Section: Discussionsupporting

confidence: 92%

“…reported that heat treatment resulted in decreased food consumption and body weight gain [20], which is in agreement with our present findings. Several studies have demonstrated that a low-protein diet caused a decrease in body weight [1, 2, 25], but in the present study, there was no significant difference in body weight between the control and low-protein groups. In the above-cited studies, an approximately 6% protein diet was used as the low-protein diet, and the lower protein content could be responsible for the more significant effect of protein malnutrition compared to that observed in the present study, in which a 10% protein diet was used as the low-protein diet.…”

Section: Discussioncontrasting

confidence: 91%

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Low-protein diet decreased the adrenal function and spontaneous activity of mice during chronic heat stress

Tsuda

Iwasawa

Yamaguchi

2019

Heliyon

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Protein restriction is a well-known risk factor that induces the deterioration of various biological functions. However, little is known about the effects of protein restriction on behavioral markers and the adrenal function of mice exposed to chronic stress. Here we evaluated the effects of a low-protein diet on the spontaneous activity and adrenal function of chronic heat-stressed mice. ICR mice were fed a control diet (20% protein) or a low-protein diet (10% protein) for 14 consecutive days. From the 10th day of the diet period, the mice were repeatedly exposed to a temperature condition of 35 ± 1 °C for 2 hr/day for four consecutive days. The spontaneous activities of the mice were estimated for the behavioral analysis. On the last day, we performed a blood collection test and an ACTH stimulation test for adrenal function analysis. For the blood collection test, mice were exposed to heat stress again for 2 hr, and blood was collected immediately after this heat stress. We measured the plasma levels of corticotropin releasing hormone, adrenocorticotropin (ACTH), and corticosterone. For the ACTH stimulation test, cosyntropin was intraperitoneally administered, and the plasma corticosterone levels were measured. The spontaneous activity of the low-protein mice was significantly lower than that of the control mice during the dark period of heat stress. The plasma corticosterone levels were greatly increased by heat stress, with no significant difference between the control and low-protein groups. The ACTH stimulation test revealed that the plasma corticosterone concentration of the heat-stressed low-protein mice was significantly lower than that of the heat-stressed controls. In conclusion, the low-protein diet decreased the spontaneous activity and the adrenal function of mice during heat stress, which implies that protein restriction during chronic heat stress induces fatigue by reducing the adrenal function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 91%

Low-protein diet decreased the adrenal function and spontaneous activity of mice during chronic heat stress

Tsuda

Iwasawa

Yamaguchi

2019

Heliyon

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“…Also in an earlier study by Lee et al., pronounced weight loss was observed in mice after a switch from a high‐fat diet to a high‐carbohydrate diet. Furthermore, the weight gain that was found after ad libitum feeding of isocaloric high‐fat and of high‐carbohydrate diets was less pronounced with the latter chow . A possible reason for this phenomenon may be that carbohydrates contributed to a lesser extent as fats to de novo lipogenesis …”

Section: Discussionmentioning

confidence: 97%

Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage

Setayesh

Mišík

Langie

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. Methods and Results Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage (“comet” formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro‐inflammatory cytokines and lower insulin levels. Conclusion The study indicates that weight loss may prevent obesity‐associated adverse health effects due to reduction of overall DNA damage.

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“…Long‐term dietary protein restriction without reducing total caloric intake has been shown to have similar beneficial effects on metabolic health and extension of longevity in mice as CR [11]. Within 1 week after the dietary switch, mice were protected against obesity and resistant to cold stress as a result of increased energy expenditure (EE) and increased utilization of free fatty acids and glucose in brown adipose tissue (BAT) [12–15].…”

Section: Introductionmentioning

confidence: 99%

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

et al. 2020

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A reduced dietary protein intake has been demonstrated to improve metabolic health under various conditions. Here, it is shown that a short‐term 7% low‐protein dietary intervention can impact age‐related metabolic health in 18‐month‐old animals. Alongside increased plasma fibroblast growth factor 21 levels, a low‐protein diet induces energy expenditure and browning of white adipose tissue in 18‐month‐old mice, without negatively affecting muscle strength.

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Low-protein, high-carbohydrate diet increases glucose uptake and fatty acid synthesis in brown adipose tissue of rats

Cited by 16 publications

References 46 publications

Low-protein diet decreased the adrenal function and spontaneous activity of mice during chronic heat stress

Low-protein diet decreased the adrenal function and spontaneous activity of mice during chronic heat stress

Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

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