The soybean rust (SBR) epidemics are often triggered by weather conditions, which interfere actively on the disease progress. Therefore, weather variables can be used to estimate the risk of occurrence and severity of SBR outbreaks. This research aimed to determine the influence of weather variables on SBR progress in different field trials in Brazil. Field experiments were conducted during 2014-15 and 2015-16 soybean growing seasons in Piracicaba (SP), Ponta Grossa (PR), Campo Verde (MT) and Pedra Preta (MT). For all sites and seasons, a susceptible soybean cultivar was drilled with 0.45 m row spacing and 12 plants per linear meter. No fungicide sprays were applied to ensure natural disease occurrence. In order to create different environmental conditions, sequential sowing dates, of roughly 30-day intervals were carried out. In Piracicaba, Ponta Grossa, Campo Verde, and Pedra Preta the main weather variables influencing SBR were leaf wetness duration - LWD (R = 0.340), air temperature during LWD (R = 0.313), and cumulative rainfall (R = 0.304). The final severity was assessed only at Piracicaba and Ponta Grossa, and it was mainly influenced by LWD (R = 0.643). It is possible to conclude that epidemics of SBR were mainly influenced by leaf wetness duration, accumulated rainfall and air temperature during the LWD. Therefore, future researches aiming to develop a disease warning system for SBR should include the cumulative rainfall, LWD and the air temperature during LWD, together or individually, as inputs.