&lt;p&gt;Anti-Tumor Activities of Bioactive Phytochemicals in &lt;em&gt;Sophora flavescens&lt;/em&gt; for Breast Cancer&lt;/p&gt;

Cao, Xianjiao; He, Qingqing

doi:10.2147/cmar.s243127

Cited by 42 publications

(32 citation statements)

References 72 publications

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“…Oxymatrine is a derivative of matrine n-oxide that is present naturally in Sophora flavescens (Xia et al, 2011;Cao and He, 2020). The research on oxymatrine and matrine suggests that oxymatrine at a dose of 63 mg/kg mouse BW remarkably mitigates the colonic damage in the mice with TNBS-mediated colitis, probably through the regulation of the imbalance of Th1/ Th2 cytokines.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation resulting from various factors. Crohn’s disease (CD) and ulcerative colitis (UC) have been identified as the two major types of IBD. Currently, most of the drugs for IBD used commonly in the clinic have adverse reactions, and only a few drugs present long-lasting treatment effects. Moreover, issues of drug resistance and disease recurrence are frequent and difficult to resolve. Together, these issues cause difficulties in treating patients with IBD. Therefore, the development of novel therapeutic agents for the prevention and treatment of IBD is of significance. In this context, research on natural compounds exhibiting anti-inflammatory activity could be a novel approach to developing effective therapeutic strategies for IBD. Phytochemicals such as astragalus polysaccharide (APS), quercetin, limonin, ginsenoside Rd, luteolin, kaempferol, and icariin are reported to be effective in IBD treatment. In brief, natural compounds with anti-inflammatory activities are considered important candidate drugs for IBD treatment. The present review discusses the potential of certain natural compounds and their synthetic derivatives in the prevention and treatment of IBD.

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Section: Alkaloidsmentioning

confidence: 99%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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“…It is reported that global statistics on female breast cancer is one of the most common cancer. Despite the year by year increase in the survival rate and the decrease in mortality rate, the side effects and the negative impact on life quality of most patients during treatment cannot be ignored [30]. Therefore, for preventing and treatment of breast cancer, a more optimal method of treatment without these side effects is a vital action [31].…”

Section: Discussionmentioning

confidence: 99%

Design and development of nanostructured co delivery of artemisinin and chrysin for targeting hTERT gene expression in breast cancer cell line: possible clinical application in cancer treatment

Azar¹,

Dadashpour²,

Firouzi-Amandi³

et al. 2021

Preprint

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Background: Breast cancer is one of the most significant causes of female cancer death worldwide. To explore the possibility of a novel chemo-preventive strategy for improving breast cancer treatment, the anticancer effects of a combination two natural compounds, Artemisinin (Art) and Chrysin (Chr), against T47D breast cancer cells were investigated.Methods: For this purpose, Art and Chr were co-encapsulated in PEGylated PLGA nanoparticles (NPs) and evaluated for their therapeutic efficacy. The morphology and dynamic light scattering (DLS) analyses were carried out to optimize the Nano formulations. Drug release study was performed using the dialysis method and then the cytotoxic and inhibitory effect of individual and combined drugs on the expression level of hTERT in the T47D breast cell line was evaluated using MTT assay and qPCR, respectively. Results: The results showed that pure drugs and formulations exhibited dose-dependent cytotoxicity against T47D cells and especially, Art/Chr–PLGA/PEG NPs had a more synergistic anti-proliferative effect and significantly arrested the growth of cancer cells than the other groups. Real-time PCR results revealed that Art, Chr and combination of Art–Chr in pure and encapsulated forms inhibited hTERT gene expression. Conclusions: It was found that Art–Chr–PLGA/PEG NPs relative to pure combination could further decline hTERT expression in all concentrations. Our study demonstrated that Art–Chr–PLGA/PEG NPs based combinational therapy holds promising potential for the treatment of breast cancer.

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“…Due to its heterogeneous, medication options are varying according to different subtypes, which include Luminal A, Luminal B, Her-2 and Basallike (or triple-negative breast cancer, TNBC) subtypes. About 30% of BRCA patients are stricken with metastasis and relapse, although treated at an early stage 1 . Therefore, it's crucial to explore biomarkers for prognosis judgment and treatment of BRCA.…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of AGR2 based on data mining reveals new insights in breast cancer

Zhou¹,

Zhang²,

Liu³

et al. 2020

Preprint

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Background: Belonging to the protein disulfide isomerase (PDI) family, anterior gradient 2 (AGR2) is overexpressed in mucus-secreting cells and endocrine organs such as breast, lung, and ovarian, but its exact function and regulation remain unclear. We aimed to perform integrative analysis of AGR2 in breast cancer.Methods: In our study, a serious of bioinformatic online databases were used to analyze the expression, regulation, prognostic value, and function of AGR2 in breast cancer.Results: The results suggested that AGR2 mRNA was overexpressed in non-basal-like or non-triple-negative breast cancer, but underexpressed in basal-like/ triple-negative breast cancer. AGR2 mRNA expression was correlated with its protein expression. Moreover, the expression of AGR2 was lower in more malignant breast cancer. Furthermore, we also found that DNA methylation, rather than copy number variation, led to AGR2 mRNA overexpression. Prognosis analysis showed no significant correlation between AGR2 level and survival, but in subtype investigation, patients with higher AGR2 level had a significantly better outcome in patients with basal-like / triple-negative breast cancer. Enrichment analysis for co-expression genes of AGR2 revealed that gene sets enriched for chromosome segregation, DNA conformation change, chromosomal region, and GABA receptor activity may play important roles in breast cancer, and that the most significant pathway was “ribosome biogenesis in eukaryotes”, in which negative co-expression genes of AGR2 were enriched.Conclusions: Overexpression of AGR2 was found in less malignant breast cancer, for the first time, our results propose that DNA methylation rather than copy number variation leads to AGR2 overexpression, which can predict favorable prognosis in basal-like/ triple-negative breast cancer, and AGR2 could be a possible regulator of ribosome biogenesis in patients with breast cancer.

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<p>Anti-Tumor Activities of Bioactive Phytochemicals in <em>Sophora flavescens</em> for Breast Cancer</p>

Cited by 42 publications

References 72 publications

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Design and development of nanostructured co delivery of artemisinin and chrysin for targeting hTERT gene expression in breast cancer cell line: possible clinical application in cancer treatment

Integrative analysis of AGR2 based on data mining reveals new insights in breast cancer

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