&lt;p&gt;Evaluation of Wound Healing Activity of &lt;em&gt;Salvia haenkei&lt;/em&gt; Hydroalcoholic Aerial Part Extract on in vitro and in vivo Experimental Models&lt;/p&gt;

Scrima, Mario; Melito, Carmela; Merola, Filomena; Iorio, Antonio; Vito, Nicoletta; Giori, Andrea Maria; Ferravante, Angela

doi:10.2147/ccid.s224418

Cited by 8 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering that several plants from the genus Salvia have been reported as wound healing agents [ 27 , 35 , 36 ], we hypothesise that S. cacaliifolia could promote wound healing. For that we resorted to the scratch assay and wound closure was assessed in the presence and absence of the essential oil in fibroblasts.…”

Section: Resultsmentioning

confidence: 99%

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Alves-Silva

Cocco

Piras

et al. 2023

Plants

View full text Add to dashboard Cite

Salvia is widely recognized for its therapeutic potential. However, the biological relevance of some species remains unknown, namely Salvia cacaliifolia Benth. Therefore, the aim of this study is to unveil the chemical composition and relevant properties to its essential oil (EO). The EO was characterized by GC and GC-MS and its antifungal effect was evaluated according to the CLSI guidelines on dermatophytes and yeasts. The anti-inflammatory potential was assessed on lipopolysaccharide-stimulated macrophages, by assessing the production of nitric oxide (NO) and the effect on the protein levels of two key pro-inflammatory enzymes, iNOS and COX-2 by western blot analysis. Wound healing capacity was determined using the scratch wound healing assay, and the anti-aging potential was assessed by evaluating the senescence marker β-galactosidase. The EO was mainly characterized by γ-curcumene, β-bisabolene, bicyclogermacrene and curzerenone. It is effective in inhibiting the growth of dermatophytes and C. neoformans. The EO significantly decreased iNOS and COX-2 protein levels and concomitantly reduced NO release. Additionally, it demonstrated anti-senescence potential and promoted wound healing. Overall, this study highlights relevant pharmacological properties of the EO of Salvia cacaliifolia, which should be further explored envisaging the development of sustainable, innovative, and environmentally friendly skin products.

show abstract

Section: Resultsmentioning

confidence: 99%

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Alves-Silva

Cocco

Piras

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…Extraction proceeded at 180 rpm at room temperature for 8 hours in a Thermo shaker, ensuring complete solution homogeneity. 31 Subsequently, the solution underwent centrifugation at 5,000 rpm using a centrifuge (Hettich Rotina 38R) for 15 minutes. Filtration was carried out employing Whatman No.1 filter paper.…”

Section: Preparation Of Hydroethanolic Extractionmentioning

confidence: 99%

Effects of Salvia Tomentosa Ointment on Dermal Wound Healing in a Rabbit Model

DEMİR,

İPEK,

TUTUN

et al. 2023

Journal of Research in Veterinary Medicine

View full text Add to dashboard Cite

This study aimed to evaluate the wound healing activity of the ointment containing hydroethonolic extract of Salvia tomentosa on a dermal wound model in rabbits. The total phenolic content and DPPH scavenging activity of the hydroethonolic extract of S. tomentosa were determined spectrophotometrically. 2.5% (w/v) and 5% (w/v) ointments were prepared with hydroethanolic extracts of Salvia tomentosa. An in vivo excisional wound model in New Zealand rabbits (n = 35) was used to assess the ointments' wound healing activity. The rabbits were randomly divided into 5 experimental groups, as negative (not receiving any treatment), vehicle (ointment vehicle), positive control (Fitokrem®), 2.5% (w/v) and 5% (w/v) S. tomentasa ointments. The wound diameters were measured using calipers on the 4th, 8th, and 14th days, and histopathological examinations were performed on the 3rd, 7th, and 14th days of treatment. The total phenolic content of S. tomentosa hydroethanolic extract was found to be 61.52 2.33 g of GAE/mg dry plant material. The DPPH scavenging activities of the extract at the concentrations of 10, 100 and 1000 μg/mL were 16.33 ± 3.49, 36.96 ± 7.22 and 72.71 ± 11.50%, respectively. In terms of wound closure, 2.5% and 5% Salvia tomentosa ointments have wound healing activity similar to Fitokrem®. As a conclusion, S. tomentosa has a positive dermal wound healing effect in rabbits.

show abstract

“…Numerous investigations have established the influence of S. officinalis on wound healing [ 220 , 221 , 222 , 223 , 224 ]. Farahpour et al [ 222 ] demonstrated that 2% and 4% ( w / w ) topical ointments of sage oil on mouse full-thickness cutaneous wounds dramatically decreased pro-inflammatory cytokines and the overall bacteria count when compared to a control group [ 222 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

et al. 2022

View full text Add to dashboard Cite

Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials.

show abstract

<p>Evaluation of Wound Healing Activity of <em>Salvia haenkei</em> Hydroalcoholic Aerial Part Extract on in vitro and in vivo Experimental Models</p>

Cited by 8 publications

References 29 publications

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Effects of Salvia Tomentosa Ointment on Dermal Wound Healing in a Rabbit Model

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

Contact Info

Product

Resources

About