Lung cancer in the Kashmir valley

Koul, Parvaiz A; Kaul, Satish Kumar; Sheikh, Mohammad Mushtaq; Tasleem, Reyaz; Shah, Azra

doi:10.4103/0970-2113.68309

Cited by 26 publications

(22 citation statements)

References 18 publications

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“…Inadequate 10 www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466 [11] In the present study among the 111 primary lung carcinomas studied, the male: female ratio is 3.5:1, with majority of the patients in 6 th decade similar to observations of Koul et al, [12] Sheikh et al [13] Jindal and Behera. [11] There are studies reporting adenocarcinoma in younger age both in men and women.…”

Section: Small Cell Carcinomas 16supporting

confidence: 79%

“…The youngest was a 24-year-old male and oldest was an 85-yearold female. Out of 111 cases, adenocarcinomas were 80 (72%) with maximum cases being in the 6th decade and squamous cell carcinomas were 31(28%) with maximum cases being in the 7 th decade (12), with male preponderance seen in both adenocarcinoma (M: F-3:1) and squamous cell carcinoma (M: F-7:1). Initial diagnosis on H&E of adenocarcinoma, 62 cases, and squamous cell carcinoma, 14 cases, were confirmed after IHC.…”

Section: Resultsmentioning

confidence: 99%

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Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies

Alekhya¹,

Rukmangadha

Lakshmi³

et al. 2018

APALM

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A prospective study on true-cut lung biopsies was done in the Department of Pathology, SVIMS, Tirupati over a period of two years and six months from March 2014 to August 2016. The research was approved by the institutional ethics committee. The computed tomography(CT) guided true cut lung biopsies specimens received in 10% buffered formalin ABSTRACTBackground: Worldwide, lung carcinoma is the most common cancer in terms of number of cases and deaths. Lung carcinomas are broadly divided into small cell carcinoma and non-small cell lung carcinoma(NSCLC). In recent years availability of targeted therapies necessitated subtyping the NSCLC to improve the survival and quality of life. NSCLC can be subtyped by routine Haematoxylin and Eosin (H&E) stained section slides alone, poorly differentiated tumors are difficult to segregate morphologically, especially in true-cut biopsies, necessitating ancillary techniques like immunohistochemistry (IHC). Hence this study was taken up to examine accuracy of diagnosis of Non-Small Cell Lung Carcinoma (NSCLC) on biopsy samples initially made based on morphology and then with IHC using relevant markers like CK5, CK6, CK7, Napsin-A, TTF-1, P63, Synaptophysin and Chromogranin-A. Methods:A prospective study of two years and six months duration during which 111 cases of NSCLC on true-cut biopsies were first reported on Haematoxylin and Eosin sections and later subjected for IHC. Results:Outof 111 cases, after IHC, 80 were diagnosed as adenocarcinoma and 31 as squamous cell carcinoma NSCLC were common in the 6th decade. In adenocarcinoma positivity for CK7, TTF1 and Napsin-A was 95%, 75%and 78.75% respectively. In squamous cell carcinoma positivity for CK5,CK6and P63 was 84%, 81% and 90% respectively. Conclusion:CK5, CK6 and P63 can be used for confirming squamous cell carcinoma and CK7, TTF-1 and Napsin-A for adenocarcinoma. We recommend a IHC panel consisting of P63, TTF1 and Napsin-A in NSCLC-unclassifiable and poorly differentiated carcinoma on H&E. Keywords

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Section: Small Cell Carcinomas 16supporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies

Alekhya¹,

Rukmangadha

Lakshmi³

et al. 2018

APALM

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“…[6] Lung cancer was reported as the second most common malignancy in an earlier hospital-based study from the Kashmir Valley of the Indian subcontinent. [7] However, a recent study by Koulet al [8] reported that Srinagar, the summer capital of Jammu and Kashmir, has the highest incidence of lung cancer among males in India.…”

Section: Discussionmentioning

confidence: 98%

Cancer in Kashmir, India: Burden and pattern of disease

Rasool¹,

Lone²,

Wani³

et al. 2012

J Can Res Ther

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“…[8,9] Higher prevalence in male is explained by smoking habit, high exposure to atmospheric pollution in outdoor activities in comparison to females but lower sex ratio in our study might be due to increasing incidence of lung cancer in women because of exposure to biomass fuel or other precipitating factors as none of our female patients were smokers. Smoker to non-smoker ratio was high in our study, but is lower to previous Indian studies showing high co-relation between smoking and lung cancer.…”

Section: Discussionmentioning

confidence: 57%

Profile of Lung Cancer Patients at Tertiary Care Hospital of North India

Kumar¹,

Luvkush²,

Verma³

et al. 2017

jemds

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BACKGROUNDCancer is a leading cause of death worldwide and lung cancer is the most common cancer in men. The aim of this study was to study the profile of patients of lung or pleural tumour and their cyto-histopathological type reporting to Department of Respiratory Diseases of GSVM Medical College, Kanpur. MATERIALS AND METHODSA total of 147 patients were included in the study. Patients were subjected to detailed history and general and systemic examination. Radiological investigations were reviewed and repeated as per requirement. Computed tomography/ Ultrasonography guided lung biopsy was done in peripherally located lesion and bronchoscopy guided procedures were performed in centrally located lesions. All histological and cytological results were noted. RESULTSIn this study, 65 patients (44.20%) were diagnosed as squamous cell carcinoma and 58 patients (39.4%) were as adenocarcinoma. 14 patients (9.5%) as small cell carcinoma, 4 patients (2.74%) as large cell carcinoma, 3 patients (2.04%) as adenosquamous cell carcinoma and 3 patients (2.04%) as pleural mesothelioma. There was higher prevalence of squamous cell carcinoma among male patients (45.2%) as compared to adenocarcinoma (40%), while this ratio was reversed in case of female patients (adenocarcinoma 46.8% and squamous cell carcinoma 31.2%). There was higher incidence of small cell carcinoma in females (21.8%) as compared to males (6%). CONCLUSIONSquamous cell carcinoma is still the most common histological type of lung cancer in male. There was relatively increased frequency of adenocarcinoma in our study as compared to other studies from India. Lung cancer is the most common cancer in men worldwide and though incidence rates is lower in females still is now the fourth most frequent cancer of women and second most common cause of death from cancer in them (GLOBOCAN 2008 cancer fact sheet). [1] Incidence rates are reportedly rising in newly industrialised and developing countries like China and India. KEYWORDS

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Lung cancer in the Kashmir valley

Cited by 26 publications

References 18 publications

Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies

Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies

Cancer in Kashmir, India: Burden and pattern of disease

Profile of Lung Cancer Patients at Tertiary Care Hospital of North India

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