Luteal Expression of Thyroid Hormone Receptors During Gestation and Postpartum in the Rat

Abstract

This study confirms for the first time the presence of TR isoforms in the CL during pregnancy and postpartum, identifying this gland as a TH target during gestation. TR expression is modulated in this tissue in accordance with the regulation of P4 metabolism, and the abrupt peripartum changes suggest a role of TH during luteolysis. However, TH actions on the CL do not seem to be related to a direct regulation of P4 synthesis.

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

“…Although the presence of TRα in the oviduct of rats has been previously described (20), regionalization was omitted. We do not have other studies to compare our results.…”

“…Studies focused on the expression of TRs and TSHR in the oviduct are scant. Immunolocalization of TRα in the epithelium and smooth musculature of ampullar and isthmic regions has been reported in rats (20). However, the presence of TRß and TSHR along the oviduct, as well as the presence of TRα in the fimbria-infundibulum and utero-tubal junction is unknown.…”

“…Immunolocalization of TRα, TRß, and TSHR has been described in the luminal or glandular epithelium, and stroma of women (16), as well as in both the endometrium and myometrium of macaques (21). In addition, the localization of TRα has been done in the luminal or glandular epithelium, and stroma, as well as in myometrium of rats (20).…”

Thyroid hormone receptors and ligands, tissue distribution and sexual behavior

“…Papers that have studied the presence of TRs in oviduct are scarce. The presence of TR a1 was described in the epithelium and smooth musculature of ampulla and isthmus in rat (Navas et al, 2014) (Table 2). Recently, the expression of all TR isoforms was shown in the luminal and glandular epithelium and in smooth muscle cells of whole oviductal regions in rabbit (Rodriguez-Castelan et al, 2017).…”

“…The localization of TR a1 and TR b1 has been found in the luminal epithelium, glandular epithelium and stroma of human endometrium throughout menstrual cycle (Aghajanova et al, 2011), however no staining was present for the a 2 isoform (Table 2). Despite the fact that the presence of binding sites for T 3 in the myometrium was shown in 1983 (Kirkland et al, 1983), only in recent years has TR a1 been described in the myometrium from macaques (Hulchiy et al, 2012), rats (Navas et al, 2014), and rabbits (Rodriguez-Castelan et al, 2017).…”