Macroporous Resin Adsorption for Purification of Flavonoids in Houttuynia cordata Thunb.

Zhang, Ying; Li, Shufen; Wu, Xiwen; Xing, Zhao

doi:10.1016/s1004-9541(08)60017-8

Cited by 38 publications

(23 citation statements)

References 4 publications

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“…Generally, maintaining a higher H/D ratio of column packing may lead to insufficient use of the bed, whereas a lower ratio may shorten the retention time of solute and reduce the mass transfer rate [19]. For the three columns tested in the current study, it was observed that the column with an H/D ratio of 7.8 gave sharp sigmoidal breakthrough curve with longer breakthrough time (Fig.…”

Section: Effect Of Column H/d Ratiomentioning

confidence: 79%

Dual gradient macroporous resin column chromatography for concurrent separation and purification of three families of marine bacterial lipopeptides from cell free broth

Dhanarajan

Rangarajan

Sen

2015

Separation and Purification Technology

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Section: Effect Of Column H/d Ratiomentioning

confidence: 79%

Dual gradient macroporous resin column chromatography for concurrent separation and purification of three families of marine bacterial lipopeptides from cell free broth

Dhanarajan

Rangarajan

Sen

2015

Separation and Purification Technology

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“…The pH effects of these adsorbents are very specific for different kinds of adsorbates. A paper (Zhang et al, 2007) reported that macroporous resin adsorbed flavonoid glycosides well at pH 2.4. Similarly, soybean isoflavones were isolated using macroporous resin at pH 7.5 (Zong and Ma, 2008), and in another case, flavonoids were isolated at a pH range of 5−6 (Lu et al, 2006).…”

Section: Resultsmentioning

confidence: 98%

Optimization of preparative separation and purification of total polyphenols from Sargassum tenerrimum by column chromatography

Haider

Lin

et al. 2009

J. Ocean Univ. China

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Polyphenols from the ethanol extracts of Sargassum tenerrimum (ST) with potent antiallergic effects were studied to optimize separation process through column chromatography. The adsorption and desorption characteristics of three widely used adsorbents: macroporous resin, silica gel, and polyvinylpolypyrrolidone (PVPP), were critically evaluated respectively and studied for the optimization of preparative separation of polyphenols. Static operations on these adsorbents showed that macroporous resin had the best adsorption and desorption capability among the three adsorbents. Dynamic adsorption and desorption with macroporous resin packed column were also conducted to optimize the parameters such as: with the optimal values shown in brackets, the concentration of extract solution (4 times diluted), pH value (6−7), adsorption speed (3 BV h -1 , bed volumes/per hour), concentration of ethanol (80%), elution speed (3 BV h -1 ) and elution volume (7 BV). The chromatographic process so optimized gave a purity of 62.43% from the crude polyphenols, providing a promising basis for large scale preparation of bioactive polyphenols upon further scaling up tests.

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“…On industrial scale, liquid-liquid extraction and macroporous resin adsorption technology are gaining popularity in pharmaceutical applications and have also been used for flavonoids purification (7)(8)(9). Liquid-liquid extraction is often based on ionic bond, hydrogen bond, and coordination bond between the extractant and the solute.…”

Section: Introductionmentioning

confidence: 99%

High Selective Separation of Flavonoids based on Crosslinked Chitosan Resin Grafted by Quercetin

Zhang

Zhou

Wang

et al. 2013

Separation Science and Technology

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In this study, crosslinked chitosan resin grafted by quercetin (QCCR) was used as a novel adsorbent to separate flavonoids. Functional quercetin groups were introduced to the adsorbent matrix, and the hydrophobic interaction occurred when these functional groups in the adsorbent approached the adsorbate with the same ring structure, which enhanced the adsorption selectivity towards flavonoids. The hydrophobic interaction played an important role in the selective adsorption. Atomic force microscopy provided intuitively the spatial conformation and the interactions between flavonoids and QCCR at the molecular level. The influences of functional groups of synthesized adsorbents on the adsorption selectivity and the optimum conditions were investigated in detail. QCCR was considered as an alternative material for obtaining the bioactive flavonoid compounds with high concentration.

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Macroporous Resin Adsorption for Purification of Flavonoids in Houttuynia cordata Thunb.

Cited by 38 publications

References 4 publications

Dual gradient macroporous resin column chromatography for concurrent separation and purification of three families of marine bacterial lipopeptides from cell free broth

Dual gradient macroporous resin column chromatography for concurrent separation and purification of three families of marine bacterial lipopeptides from cell free broth

Optimization of preparative separation and purification of total polyphenols from Sargassum tenerrimum by column chromatography

High Selective Separation of Flavonoids based on Crosslinked Chitosan Resin Grafted by Quercetin

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