Mainstreaming Mice

Babineau, Brooke A.; Yang, Mu; Crawley, Jacqueline N.

doi:10.1038/npp.2011.168

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…We suggest that the reduced NOP might be a precursor to the diminished interest in social stimuli seen in adult mice. Early detection is an avenue worth exploring, in order to assess early remediation of social deficits [68] in rodent models. The delayed development of pup reflexes reported here in males treated with CPF and in the PON1-/-genotype mirrors the subtle neurological signs reported in children and infants who later are diagnosed with ASD.…”

Section: Discussionmentioning

confidence: 99%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Mutant mice lacking the gene for paraoxo-nase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation. Three experiments were performed comparing PON1-/mice to PON1 +/+ mice born to dams treated with 0.5 mg/kg chlorpyrifos or cornoil vehicle on gestational days 12-15. Chlofpyrifos-exposed male PON1-/mouse pups had delayed development of reflexes in in the first experiment. In the second experiment, adult male and female PON1-/mice and the female PON1 +/+ mice all displayed lower social preference than the male vehicle-treated PON1 +/+ mice. The PON1-/mice and the female PON1 +/+ mice displayed lower social preference compared to the PON1 +/+ male mice. Male adult mice that had been exposed in utero to chlorpyrifos showed less conditioned social preference regardless of genotype. In the third study, the delayed reflex development was replicated in male and female PON1-/mice, but chlorpyrifos did not augment this effect. Nest Odor Preference, a test of early social attachment to dam and siblings, was lower in PON1-/mouse pups compared to PON1 +/+ pups. This study shows for the first time that PON1-/mice have a behavioral phenotype that indicates impaired reflex development and social behavior. Chlorpyrifos exposure during gestation tended to augment some of these effects.

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Section: Discussionmentioning

confidence: 99%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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Modeling of human brain diseases in experiments on rodents (brief overview)

Perepelkina

Полетаева

A.Yu.

2016

Современная Зарубежная Психология

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The review summarizes the successes and difficulties in creating and using biological models of the human brain diseases, which belongs to the important issues of applied Neurobiology. The review mentions and attempts to theoretically comprehend the relative role of genotype, environmental influences and their dynamic interactions (LEARN concept). The article reviews the examples of developed genetic models of human diseases (Alzheimer's, Down syndrome, Autism, etc.). When creating models of anxiety disorders the focus is made on the difficult problem of "norm" and "pathology", as well as the importance of integrating and understanding species specific behavior of animals used as biological models of this kind.

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Mainstreaming Mice

Cited by 2 publications

References 6 publications

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

Modeling of human brain diseases in experiments on rodents (brief overview)

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