Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

Łoniewski, Igor; Misera, Agata; Skonieczna-Żydecka, Karolina; Kaczmarczyk, Mariusz; Kaźmierczak-Siedlecka, Karolina; Misiak, Błażej; Marlicz, Wojciech; Samochowiec, Jerzy

doi:10.1016/j.pnpbp.2020.110111

Cited by 37 publications

(45 citation statements)

References 139 publications

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“…remains unclear. It has been reported that the microbiome can affect a range of neurotransmitters, including GABA and glutamatergic neurotransmitters, which may affect brain activity directly (Duranti et al, 2020;Łoniewski et al, 2021). In the present study, we found that GABA was increased in the feces metabolome profile of the CSDS mice.…”

Section: Discussionsupporting

confidence: 60%

Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice

et al. 2021

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The microbiota–gut–brain axis has been considered to play an important role in the development of depression, but the underlying mechanism remains unclear. The gastrointestinal tract is home to trillions of microbiota and the colon is considered an important site for the interaction between microbiota and host, but few studies have been conducted to evaluate the alterations in the colon. Accordingly, in this study, we established a chronic social defeated stress (CSDS) mice model of depression. We applied 16S rRNA gene sequencing to assess the gut microbial composition and gas and liquid chromatography–mass spectroscopy to identify fecal metabolites and colonic lipids, respectively. Meanwhile, we used Spearman’s correlation analysis method to evaluate the associations between the gut microbiota, fecal metabolites, colonic lipids, and behavioral index. In total, there were 20 bacterial taxa and 18 bacterial taxa significantly increased and decreased, respectively, in the CSDS mice. Further, microbial functional prediction demonstrated a disturbance of lipid, carbohydrate, and amino acid metabolism in the CSDS mice. We also found 20 differential fecal metabolites and 36 differential colonic lipids (in the category of glycerolipids, glycerophospholipids, and sphingolipids) in the CSDS mice. Moreover, correlation analysis showed that fecal metabolomic signature was associated with the alterations in the gut microbiota composition and colonic lipidomic profile. Of note, three lipids [PC(16:0/20:4), PG(22:6/22:6), and PI(18:0/20:3), all in the category of glycerophospholipids] were significantly associated with anxiety- and depression-like phenotypes in mice. Taken together, our results indicated that the gut microbiota might be involved in the pathogenesis of depression via influencing fecal metabolites and colonic glycerophospholipid metabolism.

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Section: Discussionsupporting

confidence: 60%

Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice

et al. 2021

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“…A neuroimaging study found that patients with MDD had higher concentrations of Bacteroides and lower Prevotella and showed differences of brain structure and function associated with emotion (41). Age, BMI, gender, nations, diet, region, diagnostic criteria, mediation, lifestyles, sample size, and subclinical symptoms often disturb the reproducibility and accuracy of results (11,42). In our study, age, BMI, and gender were similar between the two groups, and a mediation factor was also considered.…”

Section: Discussionmentioning

confidence: 59%

Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

Zhang

Yun

et al. 2021

Front. Psychiatry

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The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD.

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“…A most promising and known method of restoring gut microbiota balance, is probiotic therapy. Studies confirm the beneficial effect of probiotic supplementation in individuals with symptoms of mood disorders [46]. In physically healthy persons with suicidal thoughts, multi-strain bacteria formulation (B. bifidum, B. lactis, L. acidophilus, L. brevis, L. casei, L. salivarius, L. lactis) reduced rumination [47].…”

Section: Discussionmentioning

confidence: 82%

Disruptions within gut microbiota composition induced by improper antibiotics therapy as a probable trigger factor for development of depression – Case Reports

Janowska¹,

Róg²,

Karakuła-Juchnowicz³

2021

Ann Agric Environ Med.

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Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

Cited by 37 publications

References 139 publications

Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice

Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice

Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

Disruptions within gut microbiota composition induced by improper antibiotics therapy as a probable trigger factor for development of depression – Case Reports

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