Malaria: Hematological Aspects

Bashawri, Layla; Mandil, Ahmed; Bahnassy, Ahmed A; Ahmed, Mohamed S.

doi:10.5144/0256-4947.2002.372

Cited by 72 publications

(112 citation statements)

References 15 publications

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“…Study by Bashawri LAM et al show 7.2% cases with Leucocytosis. 3 Sharma SK et al and Biswas R et al show 13.3% and 12.2% cases respectively which are almost similar to the present study. 8,21 More prominent rise (20%) was reported by Ladhani Set al who studied falciparum cases only, and Echieverri M et al studying vivax cases had only 5% cases of leucocytosis.…”

Section: Studiessupporting

confidence: 91%

“…In studies conducted by Erhart LM et al, Jadhav UM et al, vivax was the most common species while Bashawri LAM et al reported higher falciparum prevalence. 3,16,17 In India, vivax is the most common species encountered followed by falciparum. However, in recent years there has been an upswing in the falciparum cases.…”

Section: Discussionmentioning

confidence: 99%

“…3 There is a wide variation in anaemia due to malaria infection depending upon the geographical location of the study. In study conducted by Richard MW et al in London only 15% cases of malaria show anaemia.…”

Section: Studiesmentioning

confidence: 99%

“…3,16,17 Thrombocytopenia is a common finding in cases of malaria both vivax and falciparum as shown by most of the studies conducted. In the present study thrombocytopenia was seen in 71% of all malaria cases.…”

Section: Studiesmentioning

confidence: 99%

“…The hematological changes that have been reported to accompany malaria include anemia, thrombocytopenia and leucocytosis, leucopenia, mild to moderate atypical lymphocytosis, monocytosis, eosinophilia and neutrophilia. [3][4][5][6][7][8] Platelet abnormalities are both qualitative as well as quantitative.…”

Section: Introductionmentioning

confidence: 99%

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Study of haematological parameters in malaria

et al. 2017

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Background: Malaria causing plasmodia are parasites of blood and hence induce haematological alterations. The haematological changes that have been reported to accompany malaria include anemia, thrombocytopenia and leucocytosis, leukopenia, mild to moderate atypical lymphocytosis, monocytosis, eosinophilia and neutrophilia.Methods: Total hundred smear positive malaria cases were taken and various hematological parameters and biochemical parameters were studied.Results: Out of 100 smear positive cases, P. vivax was positive in 55 cases while P. falciparum was positive in 45 cases. It was seen in 86.67% of falciparum Malaria patients and in 72.72% of vivax Malaria patients. Severe anemia was seen in 9% of patients. Normocytic normochromic blood picture was the most common type in anaemic patients (51.89%). Thrombocytopenia was seen in 71% of the patients. Mild thrombocytopenia was more common and present in 52% of patients while Severe thrombocytopenia was seen in 19% of cases. In falciparum malaria thrombocytopenia was present in 66.66% of the patients while it was present in 74.54% of the patients in vivax malaria. Total Leucocyte Count was normal in 72% of the patients.Conclusions: Various haematological findings can help in early diagnosis of malaria which is essential for timely and appropriate treatment which can limit the morbidity and prevent further complications.

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Section: Studiessupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Studiesmentioning

confidence: 99%

Section: Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of haematological parameters in malaria

et al. 2017

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Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients

et al. 2017

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Interaction between malaria, anaemia and malnutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Saharan Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorption spectrophotometer respectively. A total of 123 (55.2%) of our study population were positive of . Infection was age-specific ( < 0.0001), and a significant proportion (88.6%) of malaria infected patients were 28.5% mild, 45.5% moderate and 14.6% severely anaemic. The severity of anaemia increases as parasite density increases. Analysis of serum micronutrients revealed a significant low level of iron (3.72 mg/l), copper (2.05 mg/l) and zinc (3.67 mg/l) in infected patients (p < 0.0001); which further increased their anaemic condition. This study confirmed a significant relationship between severity of anaemia and nutritional deficiency in the pathogenesis of malaria infection. We therefore, recommend that immunomodulation potential of micronutrients may be essential in the management of malaria infection.

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