Malignant transformation of pleomorphic xanthoastrocytoma: case report

Tella, Oswaldo Inácio de; Herculano, Marco Antonio; Prandini, Mirto Nelso; Stávale, João Norberto; Aguiar, Paulo Henrique Pires de

doi:10.1590/s0004-282x2003000100020

Cited by 25 publications

(15 citation statements)

References 9 publications

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“…Sparse to numerous mitoses in the first specimens were noted by Macaulay et al [11], Bayindir et al [13], and Tonn et al [14]. Lymphocytic infiltration was noted for cases reported by Kepes et al [9], Allegranza et al [10], Macaulay et al [11], Tonn et al [14]and de Tella et al [18]. Once the malignant transformation occurred, the anaplastic PXA cases exhibited both endothelial proliferation [10, 14, 17, 18]and pseudopalisading [10, 11]in addition to necrosis and mitosis.…”

Section: Discussionmentioning

confidence: 96%

“…Our search revealed 15 fully documented PXA cases that had shown malignant transformation [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18]. Case 4 of Whittle et al [40], who had an extensive recurrence that took place only 5 months after initial surgery, was not included since a specimen for histological evaluation was not available either from surgery or autopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Early PXA literature with a short follow-up quoted a 6–9% rate for malignant transformation of typical PXA cases [6]. A review of the literature revealed 15 cases with PXA that had undergone anaplastic transformation [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18]. PXAs with anaplastic features at first presentation are more exceptional lesions, with only 11 reported cases of primary anaplastic PXA [19, 20, 21, 22, 23, 24].…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic Pleomorphic Xanthoastrocytomas

Tekkök

Sav

2004

Pediatr Neurosurg

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Malignancy potential of pleomorphic xanthoastrocytomas (PXAs) has rather been an underestimated reality. We report the case of a 13-year-old boy who presented with signs of increased intracranial pressure. The child had been epileptic since the age of 2. Computed tomography and magnetic resonance scans revealed a huge left frontal mass. At surgery, a subtotal excision was accomplished. Histopathological diagnosis was anaplastic PXA (grade III; WHO, 2000). The tumor showed an increased mitotic index and minimal endothelial proliferation. The patient died 3.5 months later due to a fatal intracranial hemorrhage. A review of the entire PXA literature revealed 15 well-documented cases of PXA with subsequent malignant transformation and 11 cases of primary anaplastic PXA. The prognosis was grim for both subsets of patients. Anaplastic PXAs clearly represent the transition between the original PXA concept and lipidized giant-cell glioblastoma.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anaplastic Pleomorphic Xanthoastrocytomas

Tekkök

Sav

2004

Pediatr Neurosurg

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“…10 Anaplastic PAxs are considered when mitosis is > 5/10hpf, necrosis and these are usually recurrence. 7,11 The studies showed 9-20% PAXs may undergo malignant transformation.…”

Section: Figure 2: Numerous Xanthoamatous Foamy Cells and Multinucleamentioning

confidence: 99%

Pleomorphic xanthoastrocytoma

et al. 2017

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Pleomorphic Xanthoastrocytomas (PXAs) are rare neoplasm of all astrocytic glial tumors, which occurs commonly in children and young adulthood. We present a case of 75-year male who presented with right side involuntary movements, unconsciousness and tongue bite. On radiological examination CT Scan Head (plain) showed well circumscribed isodense lesion measuring 7.2 x 5.6 x 4.8 cm at the temporoparietal region left side causing displacement of basal ganglia. On histopathological examination, diagnosed as pleomorphic xanthoastrocytoma, of left temporoparietal region. We present this report for its presentation at late age, its clinical, radiological and histomorphological features.

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“…Examples of this unusual neoplasm have also been reported in the cerebellum (11,12,14,23,31,35), pineal region (27), sella turcica (2), spinal cord (15,26), and even the retina (40). PXA often arises in adolescents and young adults and is amenable to surgical resection with good disease control (8), although it may harbor the potential for malignant transformation (1, 4, 5,6,9,25,28,30,32,38). To our knowledge, this is the first reported case of a solid PXA located exclusively within the third ventricle, a site not previously described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Intraventricular pleomorphic xanthoastrocytoma: a case report

Menéndez¹,

Fernández²,

MonTI³

et al. 2014

Turkish Neurosurgery

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Pleomorphic xanthoastrocytoma (PXA), an uncommon glial neoplasm, typically affects adolescents and young adults and accounts for less than 1% of all astrocytic neoplasms. The authors present a case of PXA located entirely in the third ventricle in a 24-year-old male patient. The patient presented with a 6-month history of headaches, progressive decline in cognitive function and profound behavioral disturbances. He was admitted to the hospital with signs of increased intracranial pressure. Magnetic resonance imaging showed a well-enhanced solid tumor, located entirely inside the third ventricle. The tumor was totally removed via a right fronto-pterional trans-lamina terminalis approach and neuropathology report confirmed PXA diagnosis. No further treatment was indicated. To the best of our knowledge, this is the first case report of a solid PXA confined to the third ventricle. KEywoRds: Pleomorphic xanthoastrocytoma, Intraventricular, Immuno-histochemical ÖZPleomorfik ksantoastrositom (PXA) nadir bir gliyal neoplazidir ve tipik olarak adolesanlar ve genç yetişkinlerde görülüp, tüm astrositik neoplazmların %1'inden azını oluşturur. Yazarlar 24 yaşında bir erkek hastada tamamen üçüncü ventrikülde bulunan PXA olgusu sunmaktadır. Hasta 6 aylık başağrısı, bilişsel işlevde giderek azalma ve belirgin davranış bozuklukları öyküsüyle geldi. Artmış intrakraniyal basınç bulgularıyla hastaneye yatırıldı. Manyetik rezonans görüntüleme tamamen üçüncü ventrikül içinde bulunan ve iyi kontrast tutan bir solid tümör gösterdi. Tümör sağ fronto-pterional trans-lamina terminalis yaklaşımı ile tamamen çıkarıldı ve nöropatoloji raporu PXA tanısını doğruladı. Başka bir tedavi gerekmedi. Bildiğimiz kadarıyla bu üçüncü ventrikülle sınırlı solid bir PXA için ilk olgu raporudur.

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Malignant transformation of pleomorphic xanthoastrocytoma: case report

Cited by 25 publications

References 9 publications

Anaplastic Pleomorphic Xanthoastrocytomas

Anaplastic Pleomorphic Xanthoastrocytomas

Pleomorphic xanthoastrocytoma

Intraventricular pleomorphic xanthoastrocytoma: a case report

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