Malnutrition and brain development

Winick, Myron

doi:10.1016/s0022-3476(69)80129-0

Cited by 324 publications

(107 citation statements)

References 26 publications

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“…If nutrient limitation affects intrauterine development, brain development is the least affected among all the organs [4] [5] . As a result, in IUGR babies muscle weight is poor but the brain is relatively well developed.…”

Section: Neurobehavioral Origin Hypothesismentioning

confidence: 99%

Hyperinsulinemia and insulin resistance : What comes first ?

Patil

Watve

2010

Nature Precedings

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Section: Neurobehavioral Origin Hypothesismentioning

confidence: 99%

Hyperinsulinemia and insulin resistance : What comes first ?

Patil

Watve

2010

Nature Precedings

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“…Early undernutrition can affect several indices of brain function, including cellular growth and differentiation and synapse formation and myelination, and it has also been established that some behaviors can be affected if undernutrition is experienced during the period of rapid brain growth (Winick, 1976). These observations may be interpreted to suggest that early undernutrition can also affect recovery from later brain damage-a hypothesis that has now been examined in three recent studies from this laboratory, using the pups of rat dams that had experienced 50010 less food than control dams during the lactation period.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Effects of early protein undernutrition and later frontal cortex damage on habit acquisition and reversallearning in the rat

Silva¹,

Bouzrara²,

Finger³

et al. 1984

Psychobiology

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Rats from dams that were undernourished (8% casein diets) during pregnancy and lactation or weH fed (25% casein diets) received frontal corticallesions at maturity. The animals were then tested for the ability to master a simple sensory discrimination and to learn reversals of that discrimination. Main effects of undernutrition and the frontal corticallesion were found in originallearning but not on the reversals, and animals that received both early undernutrition and the later focal brain lesion made more errors in originallearning than did rats that sustained only undernutrition or only the lesion. The suggestion that early nutritional history may be one of a number of factors that can help to explain why patients with seemingly similar brain lesions do not always show identical symptoms is discussed.Subjects who receive lesions of the same brain structures do not always exhibit identical degrees of behavioral impairment (Finger & Stein, 1982). Several factors have now been proposed to account for this variability, which has been observed both with clinical populations and laboratory animals. For example, under some conditions it is known that age at the time of insult can affect the degree of functional sparing (Johnson & Almli, 1978), as can the speed of growth or "momentum" of the lesion (Finger, 1978b). In addition, nonspecific environmental "enrichment" has also been shown to enhance behavioral recovery, at least on simple maze-learning tasks following cortical or hippocampal lesions (Finger, 1978a).A variable that has only recently been explored in this context is the early nutritional history of the sub-[ect. Early undernutrition can affect several indices of brain function, including cellular growth and differentiation and synapse formation and myelination, and it has also been established that some behaviors can be affected if undernutrition is experienced during the period of rapid brain growth (Winick, 1976). These observations may be interpreted to suggest that early undernutrition can also affect recovery from later brain damage-a hypothesis that has now been examined in three recent studies from this laboratory, using the pups of rat dams that had experienced 50010 less food than control dams during the lactation period.The results of two of these studies have shown that early undernutrition can affect performance following a brain lesion later in life, even under conditions in which poor early diet has little or no effect on the scores of rats without focal brain lesions. In one case (Mangold, Bell, Gruenthal, & Finger, 1981), in which rats with posterior corticallesions were tested for the ability to make a brightness discrimination, poor early nutrition retarded recovery following the focal lesion. In the other, in which rats with hippocampal lesions were tested on a battery of DRL operant conditioning tasks, undernutrition attenuated the lesion effect (Finger & Green, 1983). The generality of the latter finding was examined in a third study (Laughlin, Finger, & Bell, 1983) in which rats were...

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“…Investigações realizadas em diversas partes do mundo evidenciam que a desnutrição protéico-calórica precoce e grave traz como conseqüência direta um retardo no crescimento físico 3,6 e no desenvolvimento mental 4,9,11,12 limitando, assim, a realização do potencial genético do ser humano e interferindo na capacidade de aprendizagem 11 .…”

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Avaliação do aproveitamento escolar de pré-escolares do Programa Centro de Educação e Alimentação do Pré-Escolar

1981

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INTRODUÇÃONo Brasil, como nas outras áreas em desenvolvimento, a criança em idade pré--escolar vem preocupando as autoridades de Saúde, Educação e Serviço Social, por razões justificadas ante um amplo conjunto de evidências.Investigações realizadas em diversas partes do mundo evidenciam que a desnutrição protéico-calórica precoce e grave traz como conseqüência direta um retardo no crescimento físico 3,6 e no desenvolvimento mental 4,9,11,12 limitando, assim, a realização do potencial genético do ser humano e interferindo na capacidade de aprendizagem 11 .Influências positivas do meio ambiente que circunda a criança ensejam-lhe oportunidade de enriquecimento, oferecendo-lhe diferentes tipos de estímulos. Chase e Martin 5 , referem que o efeito do meio familiar sobre o desenvolvimento intelectual da criança sugere que a inteligência da mãe afeta o sistema de linguagem que ela emprega em sua interação com os filhos; isto pode constituir fator crítico no desenvolvimento da linguagem e de habilidades cognitivas de pré-escolares.A falta de atendimento integral, prévio e precoce a pré-escolares interfere negativa-

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Malnutrition and brain development

Cited by 324 publications

References 26 publications

Hyperinsulinemia and insulin resistance : What comes first ?

Hyperinsulinemia and insulin resistance : What comes first ?

Effects of early protein undernutrition and later frontal cortex damage on habit acquisition and reversallearning in the rat

Avaliação do aproveitamento escolar de pré-escolares do Programa Centro de Educação e Alimentação do Pré-Escolar

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