Disaster mitigation studies with a geographical, social and cultural approach can be carried out on a system of place names known as toponymy. Toponomy generally has a relationship with the characteristics of the region. Sumberagung Village, located in Pracimantoro District, Wonogiri Regency, Central Java, has a unique character as a karst area. This study aims to analyze the toponymy of Sumberagung Village which is related to the spatial, social, and cultural context as a study of disaster mitigation in the region. The research method uses descriptive qualitative analysis with interview techniques, documentation and field surveys. The results of the study show that the Toponymy of Sumberagung Village contradicts the factual conditions of the environment. The name “Sumberagung” which means a large water source has the characteristics of an area that is prone to drought. The history of the name Sumberagung Village comes from deep contemplation, prayer and hope to find a large source of water that can be used in mitigating drought. The expectation of a large supply of water forces the community and the government to make efforts which are manifested as policies, tracing karts water sources that are below the surface, and providing water resources infrastructure. These efforts show that toponymy indirectly has a relationship with disaster mitigation in Sumberagung Village.