Management Practices that Influence Wound Infection and Healing

Dart, Andrew; Sole‐Guitart, Albert; Stashak, Ted S.; Theoret, Christine L.

doi:10.1002/9781118999219.ch4

Cited by 8 publications

(14 citation statements)

References 145 publications

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“…Following each treatment, bandages were used to keep the area clean, protect the newly granulated tissue from drying out too rapidly, and keep the product on the wound surface [ 52 ]. Once a healthy layer of infection-resistant granulation tissue had formed, the bandages were removed as soon as possible to prevent the formation of exuberant granulation tissue [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although chronic wounds should be considered infected [44], the use of an antiseptic to lessen the wound's estimated bacterial population may be beneficial [45]. The general consensus is that using antiseptic dressings sparingly can be a valuable alternative for controlling infection and promoting healing in open wounds [8,46,47]. Povidone-iodine 1% [28] was selected since it is the most commonly used iodine in clinical settings, which retains broad-spectrum antibacterial, anti-fungal, and anti-viral effects while reducing tissue toxicity as recommended in contaminated wounds [8,12,45].…”

Section: Discussionmentioning

confidence: 99%

“…Many horse skin wounds are not healed by the first intention due to difficult suturing owing to substantial soft tissue loss, https://doi.org/10.5187/jast.2022.e52 high skin tension, motion, infection susceptibility, inadequate blood supply, partial or full wound dehiscence, or a long interval after injury [6,7]. Clinically, horses with improperly healed distal limb injuries provide an ongoing challenge due to the prolonged inflammatory phase, decreased contraction, and epithelialization [8,9]. All these factors directly interfere with wound healing; thus, often making healing with a secondary intention the only choice [5,10].…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Helal¹,

Al-Abbadi²,

El-Daharawy³

et al. 2022

J Anim Sci Technol

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Delayed healing associated with distal limb wounds is highly challenging in equine clinical practice. This study aimed to evaluate healing rates between chronic non-granulating wounds of horse distal limbs that were treated with maltodextrin/ascorbic acid gel alone or in combination with povidone-iodine 1% solution and those treated with povidone-iodine 1% only throughout the study period (35 days) in clinical settings. The study was conducted on 18 adult horses (3–15 years old). Based on the treatment regimen utilized, the horses were divided into three groups (n = 6), with each group having a similar mean wound area. The percentages of wound contraction, epithelialization, and overall wound healing were determined weekly for each wound. By the end of the study, the total wound healing percentage was significantly increased between the study groups ( p < 0.05). The use of maltodextrin/ascorbic acid gel resulted in considerable wound contraction, rapid epithelialization, and complication-free wound healing. Based on the findings of this study, maltodextrin/ascorbic acid gel, independently or in combination with a 1% povidone-iodine solution, might be applied as a safe and effective wound healing promoting agent in horses with chronic non-granulating wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Helal¹,

Al-Abbadi²,

El-Daharawy³

et al. 2022

J Anim Sci Technol

View full text Add to dashboard Cite

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“…It is crucial to prevent infection, thereby removing a major source of failure for laceration healing . Local administration of antibiotic substances has several advantages over systemic administration; such as decrease in cost and reaching high concentrations in the target location while avoiding the risk of side effects that might occur with systemic antimicrobial administration .…”

Section: Discussionmentioning

confidence: 99%

“…Prior to MGH application, all wounds were cleansed thoroughly using either diluted chlorhexidine (114, 89.8%) or diluted povidone iodine (4, 3.1%) followed by balanced sterile electrolyte solution (113, 89%) and debrided as needed. Systemic antibiotics were administered to 118 horses (93%), most commonly penicillin alone (74, 58.3%) or in combination (15,11.8%) with either streptomycin (7, 5.5%), enrofloxacin (4), marbofloxacin (2), sulfamethoprim (1) or gentamicin (1). Other antibiotic used includes: sulfamethoprim (14, 11%), cefquinome (9, 7.1%) and enrofloxacin (6, 4.7%).…”

Section: Study Populationmentioning

confidence: 99%

Intralesional application of medical grade honey improves healing of surgically treated lacerations in horses

Mandel

Sutton

Abu

et al. 2019

Equine Veterinary Journal

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Summary Background Infection and dehiscence of simple lacerations is common in horses, and consistently effective methods of prevention are yet to be found. Honey has been shown to promote wound healing when applied topically; however, intralesional application prior to wound closure has not been reported. Objectives To examine whether intralesional application of medical grade honey (MGH) would reduce the incidence of infection and dehiscence following wound closure. Study design Prospective, open‐label randomised block design clinical study. Methods Lacerations, treated by field practitioners, were divided into treatment and control groups using block randomisation. Horses in the treatment group received a single intralesional treatment with l‐mesitran gel (MGH). Data were collected at the time of wound closure and at suture removal. Results Data from 127 horses were included, 69 MGH‐treated and 58 control cases. No adverse effects of the MGH were recorded. MGH‐treated horses were more likely to completely heal (P = 0.006, odds ratio [OR] 3.40 95% confidence interval [CI] 1.41–8.20), to have no signs of infection (P = 0.007, OR 3.64, CI 1.42–9.26) and for the veterinarians to report some degree of satisfaction (P = 0.04, OR 2.72, CI 1.05–7.09) compared to control cases. Numbers needed to treat for complete healing was 5.1 (CI 2.8–40). Main limitations Clinical studies have inherent flaws compared to wound healing models, because of variability between wounds. There were more horses with limb injuries in the control group, although not statistically significant, this may have biased the results. Clinical satisfaction and signs of infection were subjective evaluations and evaluators were not blinded to the treatment group. Conclusions Intralesional application of MGH to lacerations prior to wound closure may be beneficial in preventing infection and dehiscence. Larger, blinded studies focusing on wounds at a specific location with more objective assessment should be pursued.

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Medical Therapy in Equine Wound Management

Hanson

2018

Veterinary Clinics of North America: Equine Practice

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Management Practices that Influence Wound Infection and Healing

Cited by 8 publications

References 145 publications

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Intralesional application of medical grade honey improves healing of surgically treated lacerations in horses

Medical Therapy in Equine Wound Management

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