Manufacture and Characterization of Mucoadhesive Buccal Films Based on Pectin and Gellan Gum Containing Triamcinolone Acetonide

Abstract

The treatment of canker sores can be quite compromised by the short period of the drug in the place of action. In this context, there is a need to develop drug dosage forms that allow more contact with the oral mucosa providing prolonged drug release. Therefore, the aim of this work was to obtain and characterize buccal films based on pectin and gellan gum in order to evaluate the potential use of these natural polymers in the production of pharmaceutical dosage forms for controlled release of TA in the oral mucosa. Using a 23 full factorial design, eight formulations were prepared by solvent casting method. The raw materials and films were characterized using techniques such as FTIR, DSC, and TG. In addition, thickness, mechanical properties, mucoadhesive strength, swelling, drug content, and dissolution profile of the films were evaluated. The results of FTIR, DSC, and TG showed that new chemical species are not formed in the production of films, and that these dosage forms have an adequate thermal behavior. All formulation showed a high degree of swelling, good mechanical resistance and elasticity, and a good mucoadhesive strength as well as able to act as a controlled release system.

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

“…Our results were in close agreement with the previously published study where gellan gum-based buccal films showed similar thermal decomposition of polymer. 61

Figure 6 DSC thermogram of Mox, blank film, and GG3.

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“… 66 Moreover, hydrophilic groups in gellan gum such as hydroxyl and carboxylic groups bind with the mucin through hydrogen bonding to facilitate mucoadhesion. 61 This prolongs the retention of films in the oral cavity by resisting the wash off effect of saliva and mastication forces for controlled release of actives.…”

Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges

“…Additionally, the interactions occurring between the particles of the hydrophilic polymers are sufficient to obtain API extended-release carriers without the use of potentially harmful cross-linking agents and organic solvents. The Korsmeyer–Peppas model was used to describe the release kinetics of triamcinolone acetate from the films, pointing to drug diffusion following Fick’s law as the mechanism for the release of the substance from the engineered films [ 47 ].…”

Mucoadhesive Polymeric Films of Acyclovir Proniosomes for Buccal Administration

“…The glass slide was placed in the bottom of the dissolution vessel, which was later filled with 900 ml of simulated saliva (phosphate buffer, pH 6.8) maintained at 37±1 °C; the paddle was rotated at 50 rpm. Samples of dissolution medium were withdrawn at predetermined time intervals, filtered, and analyzed by UV Spectrophotometry after suitable dilution [28]. To maintain sink conditions the samples were replaced with equal volumes of fresh buffer.…”