Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Abstract

Neurological disorders occur due to recognition of neurological repairs and resources are indirectly scarce, especially in low income and developing countries. They are disorders of the central nervous system and common cause of physiological and economic burden worldwide. Alzheimer's disease (AD) and other dementias is one of the progressive neurodegenerative disorders which causes memory loss and cognitive impairment due to aggregation of misfolded proteins and neurofibrillar tangles in brain. The failure of the conventional drugs to decline disease progression accompanied with numerous adverse effects has forced the researchers to look for efficient drug candidates from alternate natural resources. The marine reservoir with its large biodiversity and untapped resource potential holds numerous molecules of biomedical and clinical importance. In this review, we hypothesize the utilization of the sulfated polysaccharides as glycobased mimetics, leading to the prevention of aggregation of plaques and protein tangles. With further screening and validation, the carbohydrates from the marine sources, thus hold immense potentials to function as alternative therapeutic agent against neurological disorders.

Antioxidant, ACE inhibitory, and acetylcholinesterase inhibitory activities of subcritical water extract of blue mussel

“…First, SCW could extract natural AChE inhibition compounds present in blue mussels. Blue mussels have been reported to have antioxidant carbohydrates which might show AChE inhibitory activity [19]. The second explanation is the contamination of the blue mussels by artificial pesticides.…”

The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease

“…AD is an irreversible progressive neurodegenerative disease leading to memory loss and cognitive deficit [3]. The etiology of AD is not fully understood, as many factors impact disease progression and presentation [4].…”

“…Sulfated polysaccharides, such as those found in seaweed, have been shown to exhibit high anti-inflammatory and antioxidant activities (Table 1) as well as the ability to scavenge free radicals [16]. Oxidative stress and inflammation are some of the leading agents in the progression of AD [3]. Nutraceuticals protect against the formation of reactive oxygen species and subsequent tissue damage; thus, seaweed polysaccharides may be a good source of nutraceuticals [18].…”