Marked Eosinophilia in Hodgkin's Disease

Major, Ralph H.; Léger, L

doi:10.1001/jama.1939.62800250001010a

Cited by 28 publications

(3 citation statements)

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“…However, eosinophils are also prominent in certain types of leukemia and lymphoma -either as members of the leukemic clone, as in chronic myeloid leukemia 1 or the acute myeloid leukemias with inversion of chromosome 16 2 or the 8:21 translocation, 3 or as normal host-responsive cells as in Hodgkin's disease. 4 For a broad understanding of the biology of eosinophils in such leukemic and lymphoma populations, it is necessary to characterize the regulatory control of eosinophils, both in normal health and in pathological states involving eosinophils.…”

Section: Introductionmentioning

confidence: 99%

The multi-organ origin of interleukin-5 in the mouse

Ryan

Willson

et al. 2001

Leukemia

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Murine Ba/F3 cells were transfected with cDNA for the ␣-chain of the murine interleukin-5 (IL-5) receptor and cloned lines of these cells were able to proliferate in response to as little as 2.5 pg/ml of IL-5. The bioassay was demonstrated to be specific for IL-5 and was able to measure IL-5 produced in culture by organs from adult C57BL/6 and BALB/c mice. The highest levels of IL-5 were produced by lung tissue but thymus and bladder consistently produced IL-5 and more variable production was observed by the heart, spleen, muscle, bone shaft, uterus and testes. Bone marrow cells produced no detectable IL-5. Observed levels of production of IL-5 were similar when using organs from mice lacking high-affinity receptors for IL-5 and from nu/nu, RAG-1−/− and NOD/SCID mice lacking T lymphocytes. In inflammatory peritoneal exudates induced by the injection of casein plus bacteria, levels of induced IL-5 were higher if the mice lacked high-affinity receptors for IL-5. The data indicate that T lymphocytes are not the dominant cellular source of IL-5 in organ-conditioned media and that local IL-5 production can occur with a wide range of normal murine organs. Leukemia (2001Leukemia ( ) 15, 1248Leukemia ( -1255

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Section: Introductionmentioning

confidence: 99%

The multi-organ origin of interleukin-5 in the mouse

Ryan

Willson

et al. 2001

Leukemia

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“…mm. (99%) found in a patient with Hodgkin's disease who also had pleural and pericardial effusions (Major and Leger, 1939).…”

Section: Discussionmentioning

confidence: 95%

Malignant lymphoma presenting with a high eosinophilia, eosinophilic pleurisy, and pericarditis

Henderson

Mejia

1969

Thorax

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“…These findings suggest that these shadows were due chiefly to eosinophil infiltration. Tissue eosinophilia is commonly seen in Hodgkin's disease and non‐Hodgkin's lymphomas of T cell lineage 3−7 . It is less frequent in non‐Hodgkin's lymphomas of B cell origin 8 .…”

Section: Discussionmentioning

confidence: 99%

Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage

Fujii

Tanimoto²,

Kiguchi³

et al. 2003

Allergology International

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A BSTRACTTissue eosinophilia is often seen in Hodgkin's disease and non-Hodgkin's lymphoma of T cell lineage. It is, however, rare in non-Hodgkin's lymphoma of B cell origin. We report a case of pulmonary infiltration with eosinophilia (PIE) syndrome accompanied with non-Hodgkin's lymphoma of B cell lineage. A 42-year-old man with a long-term history of bronchial asthma consulted the local hospital due to high fever and bilateral cervical lymphadenopathy. He was diagnosed as having non-Hodgkin's lymphoma and was referred to our hospital. Marked blood eosinophilia and infiltrative shadows in both middle lung fields were recognized. After six courses of chemotherapy, including prednisolone, the shadows were ameliorated, although cervical lymphadenopathy did not show any regression, indicating refractory lymphoma. To investigate pulmonary shadows, we performed transbronchial lung biopsy and bronchoalveolar lavage (BAL) at the peak of disease activity before systemic chemotherapy. The eosinophil recruiting and activating factor interleukin (IL)-5 was undetectable in both serum and BAL fluid. Moreover, in the specimen obtained from lung biopsy, tissue eosinophilia was pathologically recognized, but IL-5 was not detected by immunohistochemical staining. These findings indicate that, in this case, any factors other than IL-5 derived from lymphoma cells may be concerned with PIE.

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Marked Eosinophilia in Hodgkin's Disease

Cited by 28 publications

References 1 publication

The multi-organ origin of interleukin-5 in the mouse

The multi-organ origin of interleukin-5 in the mouse

Malignant lymphoma presenting with a high eosinophilia, eosinophilic pleurisy, and pericarditis

Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage

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