Material properties of chitosan from shells of Egeria radiata: Drug delivery considerations

Majekodunmi, Stephen Olaribigbe; Olorunsola, Emmanuel O.; Ofiwe, Uche Collins; Udobre, Aniefiok; Akpan, Ekefre

doi:10.12980/jclm.5.2017j7-2

Cited by 12 publications

(18 citation statements)

References 10 publications

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“…Metronidazole powder was a gift from May and Baker, Ikeja, Lagos; extracted chitosan from oyster shells of Egeria radiata as previously extracted by Majekodunmi et al [5]; standard chitosan was obtained from Sigma Aldrich (St Loius, MO, USA). All other reagents and materials are of analytical grades.…”

Section: Methodsmentioning

confidence: 99%

“…The alkali was drained and the chitosan was washed repeatedly with distilled water until the pH was lowered. The resulting chitosan was dried at room temperature and then stored in a bottle until needed [5]. The quality control method of the chitosan has been given elsewhere [5].…”

Section: Extraction Of Chitosanmentioning

confidence: 99%

“…Egeria radiata (Larmack) Fig. 1, Family-Donacidae, a mollusk in the class of bivalvia, of the order Veneroida is found in large fresh rivers of western Africa including Cross River and Akwa-Ibom state of Nigeria [5]; Local name: Nkop, sanaga (Cameroon) (Etim and Brey 1994).…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata

Majekodunmi

Akpan

2017

BJPR

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Objective: The present study investigates the capability of preparing metronidazole loaded microspheres employing a natural chitosan extracted from oyster shells of Egeria radiata. Methods: Microspheres were prepared by external gelation technique using tripolyphosphate (TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug quantities with varying amount of TPP. The prepared microspheres were characterized for % yield, drug entrapment efficiency, surface morphology and drug release profile. Results: Almost spherical, rough and porous microspheres were obtained. % yield and drug entrapment efficiency were found to be in the range of 63.5-70.8% and 63.4-77.5% respectively; and about 80% of the drug was released in about 6 hours. Conclusion: The results revealed that formulation of metronidazole loaded microspheres in natural chitosan from an oyster shell can be used as a potential oral drug delivery system.

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Section: Methodsmentioning

confidence: 99%

Section: Extraction Of Chitosanmentioning

confidence: 99%

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Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata

Majekodunmi

Akpan

2017

BJPR

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“…Generally, chitosan comes from animals that have outer and hard skin such as crabs, shrimp, insects, oyster shells and other marine animals. 1 Therefore, coastal and marine resources such as white shrimp shells (Penaeus merguiensis) can be used as a potential source of chitosan because they're composed of chitin (20-25%). There are about 40% of shrimp weight becomes waste which mainly consists of chitin (20-25%), pigments, calcium carbonate (30%), protein and lipid.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Previous studies required a longer time 1,9 of isolation and produced a low yield 9 as well as a low degree of deacetylation of chitosan product. 1 In this study, chitosan was isolated by a modification of reported method 9 to make isolation process going faster and give higher in yield and degree of deacetylation. This research is expected to overcome problems related to household waste in the form of shrimp shells and water problems with iron (Fe) and manganese (Mn) content in Kota Langsa.font 12, spacing…”

Section: Introductionmentioning

confidence: 99%

Chitosan Isolation and Its Application to Reduce the Content of Metal Ions in Wellbore Water

Amri

Fajri

Batu

2020

Jurnal Fisika dan Aplikasinya

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Potential water sources such as white shrimp shell waste (Penaeus merguiensis) can be used as a source of chitosan. Chitosan can be applied as an environmentally friendly adsorbent for water treatment because of its ability to adsorb metal ions. In this study, chitosan was isolated through several stages such as demineralization, deproteination, decolourization and deacetylation. The yield of chitosan obtained from this study was 17.73%. Characterization by infrared spectroscopy (FTIR) showed the absorption at 3355 cm -1 indicating the presence of amine (-NH2) and hydroxyl (-OH) groups. The absorption of the carbonyl group (-C=O) at 1642 cm -1 disappeared while the absorption of the free amine group (-NH2) at 1590 cm -1 increased indicating the successful deacetylation with a degree of deacetylation (DD) 78%. Application of chitosan in wellbore water did not affect on colour change and decreasing of iron (Fe) content due to low concentration of iron (Fe). However, chitosan can reduce the pH value of water and manganese (Mn) content. The results of ANOVA and DMRT test at 0.05 significance level showed that chitosan with various mass had different effects. The more the mass of chitosan added, the higher the content of manganese (Mn) will decrease.

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β‐Chitin and chitosan from waste shells of edible mollusks as a functional ingredient

Karthick Rajan,

Mohan,

Rajarajeswaran

et al. 2023

Food Frontiers

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The marine food‐processing industries were producing large quantities of shell wastes as a discard. Currently, this waste material was underutilized and leads to the landfill as a significant environmental issue. The outer shells or exoskeletons of mollusks serve as the best source of chitin. Three different allomorphs of chitin (γ, β, and γ) were extracted from different species of crustaceans, mollusks, and fungi. β‐Allomorphs predominantly exist in the shells of mollusks. β‐Chitin and its deacetylated product chitosan has been utilized for its special characteristic features, including biocompatibility, environmental friendly, and nontoxic properties. The extraction of β‐chitin and chitosan from the mollusk shell waste were evaluated in this work. Hence, this review aims to explore edible mollusk shell waste sources and its suitable extraction techniques, characterizations, and functional properties of mollusk‐based β‐chitin and chitosan. Further, the genetic pathway of synthesizing mollusk chitin was discussed. The entire life cycle assessment with techno‐economic aspects were extrapolated to study the bottlenecks and tangible solution for the industrial upscaling of obtaining β‐chitin and chitosan from the edible mollusk shell waste have been reviewed herein.

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Material properties of chitosan from shells of Egeria radiata: Drug delivery considerations

Cited by 12 publications

References 10 publications

Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata

Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata

Chitosan Isolation and Its Application to Reduce the Content of Metal Ions in Wellbore Water

β‐Chitin and chitosan from waste shells of edible mollusks as a functional ingredient

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