Maternal Choline Supplementation Modulates Placental Markers of Inflammation, Angiogenesis, and Apoptosis in a Mouse Model of Placental Insufficiency

King, Julia H; Kwan, Sze Ting Cecilia; Yan, Jian; Jiang, Xinyin; Fomin, Vladislav G; Levine, Samantha; Wei, Emily; Roberson, Mark S.; Caudill, Marie A.

doi:10.3390/nu11020374

Cited by 20 publications

(16 citation statements)

References 38 publications

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“…This indicated that choline shortfalls could contribute to placental dysfunction [147]. Further to this, rodent data also shows that prenatal choline supply could be an effective nutritional approach to attenuate placental insufficiency [140,148].…”

Section: Discussionmentioning

confidence: 78%

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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The foundations of neurodevelopment across an individual’s lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function. Of these, evidence for choline has been building but has not been widely collated using systematic approaches. Therefore, a systematic review was performed to identify the animal and human studies looking at inter-relationships between choline, neurological development, and brain function during the first 1000 days of life. The database PubMed was used, and reference lists were searched. In total, 813 publications were subject to the title/abstract review, and 38 animal and 16 human studies were included after evaluation. Findings suggest that supplementing the maternal or child’s diet with choline over the first 1000 days of life could subsequently: (1) support normal brain development (animal and human evidence), (2) protect against neural and metabolic insults, particularly when the fetus is exposed to alcohol (animal and human evidence), and (3) improve neural and cognitive functioning (animal evidence). Overall, most offspring would benefit from increased choline supply during the first 1000 days of life, particularly in relation to helping facilitate normal brain development. Health policies and guidelines should consider re-evaluation to help communicate and impart potential choline benefits through diet and/or supplementation approaches across this critical life stage.

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Section: Discussionmentioning

confidence: 78%

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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“…Inadequate vascularization of the placenta can lead to pregnancy disorders characterized by impaired fetal growth such as intrauterine growth restriction (IUGR) and preeclampsia [57]. Emerging data from a growing number of studies suggest that choline supply can beneficially influence functional processes of the placenta, including angiogenesis [50,58,59], inflammation [58,59,60], and macronutrient transport [61]. Based on rodent data, prenatal choline may also be a nutritional approach to mitigate placental insufficiency [60,62].…”

Section: Choline and Pregnancy Outcomesmentioning

confidence: 99%

“…Emerging data from a growing number of studies suggest that choline supply can beneficially influence functional processes of the placenta, including angiogenesis [50,58,59], inflammation [58,59,60], and macronutrient transport [61]. Based on rodent data, prenatal choline may also be a nutritional approach to mitigate placental insufficiency [60,62]. In the Dlx3 ± mouse model of placental insufficiency, gestational choline improved early fetal growth [62], possibly by increasing the size of the placental labyrinth [60], a region of the placenta that contains the villi where nutrients pass from the maternal blood into the fetal blood.…”

Section: Choline and Pregnancy Outcomesmentioning

confidence: 99%

“…Based on rodent data, prenatal choline may also be a nutritional approach to mitigate placental insufficiency [60,62]. In the Dlx3 ± mouse model of placental insufficiency, gestational choline improved early fetal growth [62], possibly by increasing the size of the placental labyrinth [60], a region of the placenta that contains the villi where nutrients pass from the maternal blood into the fetal blood.…”

Section: Choline and Pregnancy Outcomesmentioning

confidence: 99%

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Choline: Exploring the Growing Science on Its Benefits for Moms and Babies

2019

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The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized. Choline is critical for a number of physiological processes during the prenatal period with roles in membrane biosynthesis and tissue expansion, neurotransmission and brain development, and methyl group donation and gene expression. Studies in animals and humans have shown that supplementing the maternal diet with additional choline improves several pregnancy outcomes and protects against certain neural and metabolic insults. Most pregnant women in the U.S. are not achieving choline intake recommendations of 450 mg/day and would likely benefit from boosting their choline intakes through dietary and/or supplemental approaches.

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“…Furthermore, increased choline supplementation during pregnancy has demonstrated downregulation of antiangiogenic factor and preeclampsia risk marker, fms-like tyrosine kinase-1 (sFLT1) in in human placental tissues [22]. Simulating decreased placental efficiency in preeclampsia and intrauterine growth restriction, the Dlx 3+/− mouse model has been used to show that dietary choline drives placental betaine concentration, which downregulates inflammatory gene expression [23] and improves fetal growth patterns [24].…”

Section: Role Of Choline In Maternal and Infant Nutritionmentioning

confidence: 99%

Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health

Mun¹,

Legette²,

Ikonte³

et al. 2019

Nutrients

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The aim of this review is to highlight current insights into the roles of choline and docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on dietary recommendations, gaps in dietary intake, and synergistic implications of both nutrients in infant brain and eye development. Adequate choline and DHA intakes are not being met by the vast majority of US adults, and even more so by women of child-bearing age. Choline and DHA play a significant role in infant brain and eye development, with inadequate intakes leading to visual and neurocognitive deficits. Emerging findings illustrate synergistic interactions between choline and DHA, indicating that insufficient intakes of one or both could have lifelong deleterious impacts on both maternal and infant health.

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Maternal Choline Supplementation Modulates Placental Markers of Inflammation, Angiogenesis, and Apoptosis in a Mouse Model of Placental Insufficiency

Cited by 20 publications

References 38 publications

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Choline: Exploring the Growing Science on Its Benefits for Moms and Babies

Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health

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